The safety of maritime activities and the organizational framework of cargo-handling and technical-nautical services

La tesi ricostruisce le principali fonti normative in materia di sicurezza marittima, approfondendo gli assetti organizzativi delle operazioni portuali e dei servizi tecnico-nautici.The thesis retraces the main law sources concerning maritime safety and security, analyzing the management structures of port operations and technical organizational frameworks of cargo handling and technical-nautical services in the light of law no. 84 of 1994

A strategy to identify breakdown location in MITICA test facility: results of high voltage test campaign

The Acceleration Grid Power Supply of the MITICA test facility in Padova (Italy) is currently under commissioning. The power conversion system, the DC generator, and the High Voltage equipment have been individually commissioned, whereas the integration tests are ongoing. It is a challenging process due to the unconventional application, to the variety of different electrical technologies involved and to the complexity of the interfaces. During the integrated tests of the power supplies the achievement of 700kV stable operation has been demonstrated for the first time in a Neutral Beam Injector, but an unexpected event occurred, most likely a breakdown in the HV part, which resulted in a fault of the DC generator. A subsequent test using an auxiliary power supply was performed to check the voltage withstanding capability of the HV plant, but another breakdown occurred at around 1MV. This paper describes the activity performed to identify the location of the breakdowns affecting the integrated tests. A test campaign has been devised with increased diagnostic capabilities and specific strategy conceived to trigger intentional breakdowns in specific locations and collect measurement patterns for different cases. The results of the campaign will be presented and the current understanding of the issue will be described, with a view on future tests and further improvements of diagnostics

Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model

Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal organs into the thoracic cavity and impeding lung development and function. Large diaphragmatic defects require correction with prosthetic patches to close the malformation. This treatment leads to a consequent generation of unwelcomed mechanical stress in the repaired diaphragm and hernia recurrences, thereby resulting in high morbidity and significant mortality rates. We proposed a specific diaphragm-derived extracellular matrix (ECM) as a scaffold for the treatment of CDH. To address this strategy, we developed a new surgical CDH mouse model to test the ability of our tissue-specific patch to regenerate damaged diaphragms. Implantation of decellularized diaphragmatic ECM-derived patches demonstrated absence of rejection or hernia recurrence, in contrast to the performance of a commercially available synthetic material. Diaphragm-derived ECM was able to promote the generation of new blood vessels, boost long-term muscle regeneration, and recover host diaphragmatic function. In addition, using a GFP\u202f+\u202fSchwann cell mouse model, we identified re-innervation of implanted patches. These results demonstrated for the first time that implantation of a tissue-specific biologic scaffold is able to promote a regenerating diaphragm muscle and overcome issues commonly related to the standard use of prosthetic materials

Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation

Rationale: Caloric restriction improves the efficacy of anti-cancer therapy. This effect is largely dependent on the increase of the extracellular ATP concentration in the tumor microenvironment (TME). Pathways for ATP release triggered by nutrient deprivation are largely unknown. Methods: The extracellular ATP (eATP) concentration was in vivo measured in the tumor microenvironment of B16F10-inoculated C57Bl/6 mice with the pmeLuc probe. Alternatively, the pmeLuc-TG-mouse was used. Caloric restriction was in vivo induced with hydroxycitrate (HC). B16F10 melanoma cells or CT26 colon carcinoma cells were in vitro exposed to serum starvation to mimic nutrient deprivation. Energy metabolism was monitored by Seahorse. Microparticle release was measured by ultracentrifugation and by Nanosight. Results: Nutrient deprivation increases eATP release despite the dramatic inhibition of intracellular energy synthesis. Under these conditions oxidative phosphorylation was dramatically impaired, mitochondria fragmented and glycolysis and lactic acid release were enhanced. Nutrient deprivation stimulated a P2X7-dependent release of ATP-loaded, mitochondria-containing, microparticles as well as of naked mitochondria. Conclusions: Nutrient deprivation promotes a striking accumulation of eATP paralleled by a large release of ATP-laden microparticles and of naked mitochondria. This is likely to be a main mechanism driving the accumulation of eATP into the TME

Overview on electrical issues faced during the SPIDER experimental campaigns

SPIDER is the full-scale prototype of the ion source of the ITER Heating Neutral Beam Injector, where negative ions of Hydrogen or Deuterium are produced by a RF generated plasma and accelerated with a set of grids up to ~100 keV. The Power Supply System is composed of high voltage dc power supplies capable of handling frequent grid breakdowns, high current dc generators for the magnetic filter field and RF generators for the plasma generation. During the first 3 years of SPIDER operation different electrical issues were discovered, understood and addressed thanks to deep analyses of the experimental results supported by modelling activities. The paper gives an overview on the observed phenomena and relevant analyses to understand them, on the effectiveness of the short-term modifications provided to SPIDER to face the encountered issues and on the design principle of long-term solutions to be introduced during the currently ongoing long shutdown.Comment: 8 pages, 12 figures. Presented at SOFT 202

240th ENMC workshop: the involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25 -27 January 2019, Hoofddorp, the Netherlands

Satellite cells are dysfunctional in several neuromuscular disorders. Some muscles are more susceptible than others to disease and ageing. In vitro and in vivo model systems have shed light on many of the processes involved. in satellite cell function and dysfunction, but the drawbacks of each model system must be considered. Skeletal muscle pathology in mouse models of neuromuscular disease are affected by genetic background. A single cell approach will be useful to identify dysfunction in subsets of cell populations

I contratti della pubblicit\ue0

Il capitolo "I contratti della pubblicit\ue0" effettua una ricognizione ed analisi dei principali schemi contrattuali dell'advertising industry relativi sia alla comunicazione pubblicitaria c.d. above the line (i.e. i contratti di agenzia pubblicitaria, i contratti di diffusione pubblicitaria, i contratti di concessione pubblicitaria, i contratti di commissione di opera pubblicitaria) che a quella c.d. below the line (in particolare, i contratti di sponsorizzazione). Nel capitolo sono inoltre analizzati i contratti per l'utilizzo dell'immagine altrui e trattati alcuni aspetti specifici dei contratti che gli inserzionisti perfezionano con gli advertising network provider

Governance amministrativa dei porti e questioni di sicurezza

L'opera ricostruisce le principali fonti normative in materia di sicurezza marittima, approfondendo gli assetti organizzativi delle operazioni portuali e dei servizi tecnico-nautici

Nota alle sentenze della Corte di Giustizia dell'Unione europea dd. 18 luglio 2013 - cause C-201/11 P, UEFA c. Commissione europea, Regno del Belgio e Regno Unito; C-204/11 P, FIFA c. Commissione europea, Regno del Belgio e Regno Unito; C-205/11 P, FIFA c. Commissione europea, Regno del Belgio e Regno Unito

La nota affronta il tema dei limiti alla tutela dei diritti audiovisivi sugli eventi sportivi derivanti dal necessario bilanciamento del diritto d'autore degli organizzatori delle competizioni con il diritto di ogni cittadino all'informazione in merito ad eventi riconosciuti di interesse generale da parte delle autorit\ue0 nazionali preposte all'attuazione della direttiva 89/552/CEE cos\uec come modificata dalla direttiva 97/36/CE