7 research outputs found
[Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles
<p>An efficient [Cu]-catalyzed homocoupling of 1,1-dibromoalk-1-enes is described for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.</p
[Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles
A Domino Palladium-Catalyzed CâC and CâO Bonds Formation via Dual OâH Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes
An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, ÎČ-carbon cleavage, and finally intramolecular BuchwaldâHartwig cyclization. This domino process effectively involves breaking of five Ï-bonds (2CâBr, 2OâH, and a CâC) and formation of two new Ï-bonds (CâC and CâO). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis
A Domino Palladium-Catalyzed CâC and CâO Bonds Formation via Dual OâH Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes
An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, ÎČ-carbon cleavage, and finally intramolecular BuchwaldâHartwig cyclization. This domino process effectively involves breaking of five Ï-bonds (2CâBr, 2OâH, and a CâC) and formation of two new Ï-bonds (CâC and CâO). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis
A Domino Palladium-Catalyzed CâC and CâO Bonds Formation via Dual OâH Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes
An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, ÎČ-carbon cleavage, and finally intramolecular BuchwaldâHartwig cyclization. This domino process effectively involves breaking of five Ï-bonds (2CâBr, 2OâH, and a CâC) and formation of two new Ï-bonds (CâC and CâO). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis