[Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles

<p>An efficient [Cu]-catalyzed homocoupling of 1,1-dibromoalk-1-enes is described for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.</p

A Domino Palladium-Catalyzed C–C and C–O Bonds Formation via Dual O–H Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes

An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald–Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C–Br, 2O–H, and a C–C) and formation of two new σ-bonds (C–C and C–O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis

A Domino Palladium-Catalyzed C–C and C–O Bonds Formation via Dual O–H Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes

An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald–Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C–Br, 2O–H, and a C–C) and formation of two new σ-bonds (C–C and C–O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis

A Domino Palladium-Catalyzed C–C and C–O Bonds Formation via Dual O–H Bond Activation: Synthesis of 6,6-Dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes

An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6<i>H</i>-benzo[<i>c</i>]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald–Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C–Br, 2O–H, and a C–C) and formation of two new σ-bonds (C–C and C–O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis