42 research outputs found

    DNA-Based Fixed Gain Amplifiers and Linear Classifier Circuits

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    DNA catalysts have been developed as methods of amplifying single-stranded nucleic acid signals. The maximum turnover (gain) of these systems, however, often varies based on strand and complex purities, and has so far not been well-controlled. Here we introduce methods for controlling the asymptotic turnover of strand displacement-based DNA catalysts and show how these could be used to construct linear classifier systems

    Sudden Cardiac Death in the Young: A Consensus Statement on Recommended Practices for Cardiac Examination by the Pathologist from the Society for Cardiovascular Pathology.

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    Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated. Across the United States, SCD cases in those less than 40 years of age will often fall under medical examiner/coroner jurisdiction resulting in scene investigation, review of available medical records and a complete autopsy including toxicological and histological studies. To date, there have not been consistent or uniform guidelines for cardiac examination in these cases. In addition, many medical examiner/coroner offices are understaffed and/or underfunded, both of which may hamper specialized examinations or studies (eg. molecular testing). Use of such guidelines by pathologists in cases of SCD in decedents aged 1 to 39 years of age could result in life-saving medical intervention for other family members. These recommendations also may provide support for underfunded offices to argue for the significance of this specialized testing. As cardiac examinations in the setting of SCD in the young fall under ME/C jurisdiction, this consensus paper has been developed with members of the Society of Cardiovascular Pathology working with cardiovascular pathology-trained, practicing forensic pathologists

    The biographical illumination: A bourdieusian analysis of the role of theory in educational research

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    The intention of this paper is to serve as a reflexive comment as to my ongoing empirical processes and epistemological position concerning research on university graduates' aspirations and expectations of graduate employment. This paper will illustrate the inevitable role of social theory in empirical research, and from a Bourdieusian position, consider the use of theory in creating a break with common sense, the danger of replacing common sense with learned bias, and processes that may aid to avoid this problematic issue. Using educational research as a tangible basis, this paper will discuss the empirical application of the habitus in creating a break with common sense, whilst not losing itself to social theory. However, in an effort to depart from simply offering a comment on the need for the application of theory in educational research, this paper intends to demonstrate how the neo-positivist biographical narrative interview method can, contrary to Bourdieu's (1987) comments, illuminate the habitus, offering an opportunity for its empirical application in educational research and also for the wider academy

    Ethnicity or tribalism? : The discursive construction of Zimbabwean national identity

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    In Zimbabwe any attempt to discuss ethnicity risks being labelled as ‘tribalism’ and, therefore, divisive to a supposedly ‘united nation.’ But what is ethnicity? This paper will attempt to discuss this issue, with particular focus on its intersection with nationalism and the construction of national identity. It will illuminate the liminal process of the ‘criminalisation of ethnicity’ through some moves aimed at blocking open discourse on ethnicity as a form of identity. Furthermore, the paper illustrates how Zimbabwe’s Shona-dominated nationalist discourses tend to follow the social constructivist path, which publicly dismisses the existence of ethnicity while clandestinely embracing it for dubious political purposes. In the process, the paper will also challenge the Eurocentric-theoretical perspectives underlying the normative engagement of ethnicity within the political and culturalist perspectives in Africa for presenting ethnicity as retrogressive and divisive. It is further argued that the scarcity of indigenous theoretical lenses of understanding ethnicity, exacerbated by grotesque forms of nationalism, as seen in Zimbabwe and elsewhere in Africa sustains the suppression of ethnic minority voices and the shrift dismissal of their issues as peripheral or regional. This lack of proper vent has thus led to the continued resurgence of violent ethnic upheavals across the African continent.Peer reviewe
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