STAT1 activation in association with JAK2 exon 12 mutations

La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder individual y colectivo que impactan en la vida de las personas y conforman la identidad del poder judicial como un actor imprescindible en la construcción de un Estado democrático de derecho” (Suprema Corte de Justicia de la Nación, 2013:7). La incorporación de la perspectiva de género viene a garantizar la igualdad de posiciones (Kessler, 2014) entre mujeres y varones como una meta, trascendiendo la mera igualdad de oportunidades que hasta el presente se ha demostrado insuficiente para que las mujeres consigamos una ciudadanía plena. Al momento de incorporar la perspectiva de género en las sentencias, quienes juzgan deben tener presente en primer lugar, el impacto diferenciado de las normas en base al sexo de las personas. En segundo lugar, la interpretación y aplicación de las leyes en relación con (y en base a) estereotipos de género. Si, por ejemplo, quienes imparten justicia no tienen presentes los estereotipos de género vigentes detrás de las violaciones a los derechos humanos de las mujeres, si no los detectan ni cuestionan, entonces los reproducen. Tal como sostiene Scott (1996) el género es una categoría imprescindible para el análisis social. En tercer lugar, al momento del juzgamiento, se deben tener en cuenta las exclusiones legitimadas por la ley por pensar el mundo en términos binarios y androcéntricos; en cuarto lugar, la distribución no equitativa de recursos y poder que opera entre varones y mujeres en el marco de una organización social patriarcal, y, por último, el trato diferenciado por género legitimado por las propias leyes.Eje 3: Tramas violentas y espacios de exclusión.Instituto de Cultura Jurídic

Producing and Detecting Correlated atoms

We discuss experiments to produce and detect atom correlations in a degenerate or nearly degenerate gas of neutral atoms. First we treat the atomic analog of the celebrated Hanbury Brown Twiss experiment, in which atom correlations result simply from interference effects without any atom interactions.We have performed this experiment for both bosons and fermions. Next we show how atom interactions produce correlated atoms using the atomic analog of spontaneous four-wavemixing. Finally, we briefly mention experiments on a one dimensional gas on an atom chip in which correlation effects due to both interference and interactions have been observed.Comment: to appear in conference proceedings "Atomic Physics 20

Quantification of three macrolide antibiotics in pharmaceutical lots by HPLC: Development, validation and application to a simultaneous separation

A new validated high performance liquid chromatographic (HPLC) method with rapid analysis time and high efficiency, for the analysis of erythromycin, azithromycin and spiramycin, under isocratic conditions with ODB RP18 as a stationary phase is described. Using an eluent composed of acetonitrile –2-methyl-2-propanol –hydrogenphosphate buffer, pH 6.5, with 1.5% triethylamine (33:7: up to 100, v/v/v), delivered at a flow-rate of 1.0 mL min-1. Ultra Violet (UV) detection is performed at 210 nm. The selectivity is satisfactory enough and no problematic interfering peaks are observed. The procedure is quantitatively characterized and repeatability, linearity, detection and quantification limits are very satisfactory. The method is applied successfully for the assay of the studied drugs in pharmaceutical dosage forms as tablets and powder for oral suspension. Recovery experiments revealed recovery of 97.13–100.28%

Lithium enrichment processes in sedimentary formation waters

International audienceReservoirs exploited for oil, gas, or geothermal energy in sedimentary basins may represent an alternative lithium resource to salars and hard rocks. Similarities in the geochemical characteristics of the basins were searched using a database of 2400 water analyses available from more than 40 sedimentary basins worldwide, notably a selection of representative geochemical trends on 13 basins. The objective was to understand better the factors controlling Li concentrations and the potentiality of such basins for the Li-recovery. Considering Lisingle bondCl and Mgsingle bondCl relationships, major cation (Na/K, Na/Ca) and halogen (Cl/Br) ratios, Li concentrations are monitored in several basins by mixing processes between low salinity recharge waters, seawater and brines. Lithium concentrations span three orders of magnitude in brines between evaporated seawater that has passed saturation with halite and a particularly Li-enriched pole. In the latter, significant Li-enrichment is obtained when brines are primary, in equilibrium with halite, and then enriched in Li through fluid-rock interaction processes. Li-rich lithologies such as volcanic rocks, Li-enriched clay formations, or Li-phyllosilicates dispersed in siliciclastic rocks or the underlying crystalline basement probably act as the primary Li sources. Finally, Li extraction is promoted by the rise in temperature, which explains the high Li concentrations in the waters of geothermal systems. Therefore, favourable reservoirs for Li-rich brines are characterised by a brine collection from evaporites during tectonic events, such as compressive events or salt tectonics, at a relatively short distance from the present reservoir. They must be preserved from convection and surface water ingress via recharge zones to prevent dilution and Li depletion

Ultracold metastable helium-4 and helium-3 gases

We discuss our work to obtain a condensate containing more than 107 atoms and the first degenerate Fermi gas in a metastable state. Sympathetic cooling with Helium-4 is used to cool 106 Helium-3 atoms to a temperature T/TF < 0.5. The ultracold bosonic and fermionic gases have been used to observe the Hanbury Brown and Twiss effect for both isotopes, showing bunching for the bosons and antibunching for the fermions. A proposal for high resolution spectroscopy at 1.557 μm, connecting both metastable states directly, is discussed at the end

STAT1 activation in association with JAK2 exon 12 mutations.

The work was supported by Leukemia and Lymphoma Research, Wellcome Trust, Medical Research Council, Kay Kendall Leukaemia Fund, Cambridge NIHR Biomedical Research Center, Cambridge Experimental Cancer Medicine Centre, Leukemia and Lymphoma Society of America and Associazione Italiana per la Ricerca sul Cancro (AIRC, Milano; Progetto AGIMM, #1005).Due to copyright this article cannot be uploaded to the repository

Treatment of acute lymphoblastic leukemia in the elderly: An evaluation of interferon alpha given as a single agent after complete remission

Although interferon (IFN) has been used in elderly patients with acute lymphoblastic leukemia (ALL), the benefits from IFN therapy have not been properly assessed, especially as it was given combined with other cytotoxic drugs, which obscured the role of IFN if any. In 1997, we started a study aimed at improving our previous results in elderly patients with ALL and at assessing the therapeutic role of IFN in this disease. Fifty-eight patients with ALL, aged 55-81 years (median: 64.9 years), were randomly allocated to treatment with vindesine or vincristine during induction. After a first consolidation course, IFN was administered as a single agent for three months together with cranial radiotherapy. Chemotherapy was then resumed with a second consolidation course and maintenance. A complete remission (CR) was obtained in 58% of patients (CI: 45-71%), significantly less than in our previous study which included IFN combined with chemotherapy during maintenance (CR: 85%, CI:70-94%, p = 0.007). Overall survival (median: 289 vs 434 days in the previous study, p = 0.01) and disease-free survival (median: 146 vs 427 days, p = 0.009) were also inferior in the present study. In particular, the pattern of relapses over time suggested that the 3 month IFN treatment phase with no additional chemotherapy might have contributed to the comparatively poor outcome of this cohort. In addition, vindesine given during induction did not prove less neurotoxic than vincristine, did not improve the CR rate, and had no impact on survival. In conclusion, although similar to published studies in elderly patients with ALL, this study is inferior to our previous one. INF, given as a single drug, has a modest role if any in the treatment of older persons with ALL