10 research outputs found
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection
- Author
- Adlam David
- Al-Hussaini Abtehale
- Alver Maris
- Anand Sonia S.
- Ardissino Diego
- Armasu Sebastian M.
- Assimes Themistocles L.
- Aubry Pierre
- Auro Kirsi
- Bali Laurent
- Barnay Pierre
- Bedossa Marc
- Belle Loïc
- Benamer Hakim
- Benamer Hakim
- Bertram Lars
- Beutner Frank
- Bjonnes Andrew
- Boerwinkle Eric
- Boiffard Emmanuel
- Borecki Ingrid B.
- Bottinger Erwin P.
- Bouajila Sara
- Bouatia-Naji Nabila
- Braund Peter S.
- Bresson Didier
- Brunel Philippe
- Buring Julie E.
- Caussin Christophe
- Cayla Guillaume
- Chambers John C.
- Champin Stanislas
- Chasman Daniel I.
- Chen Shufeng
- Clarke Robert
- Collins Rory
- Combaret Nicolas
- Commeau Philippe
- Cottin Yves
- Cupples L Adrienne
- Danesh John
- de Andrade Mariza
- de Andrade Mariza
- De Poli Fabien
- de Vries Paul S.
- Dedoussis George
- Dehghan Abbas
- Delarche Nicolas
- Deloukas Panos
- Demuth Ilja
- Dubreuil Olivier
- Ducrocq Grégory
- Dunwoodie Sally L.
- Dupouy Patrick
- d’Escamard Valentina
- Elosua Roberto
- Empana Jean-Philippe
- Epstein Stephen E.
- Erdmann Jeanette
- Esko Tõnu
- Farrall Martin
- Fatkin Diane
- Feitosa Mary F.
- Filippi Emmanuelle
- Fluttaz Arnaud
- Ford Ian
- Franceschini Nora
- Franco Oscar H.
- Franzosi Maria Grazia
- Frossard Philippe
- Gauguier Dominique
- Georges Adrien
- Georges Jean Louis
- Gerbaud Edouard
- Gerbay Antoine
- Giannoulatou Eleni
- Gieger Christian
- Gilard Martine
- Goel Anuj
- Goodall Alison H.
- Gottesman Omri
- Grace Christopher
- Graham Robert M.
- Granger Christopher B.
- Gu Dongfeng
- Gudnason Vilmundur
- Gulati Rajiv
- Gustafsson Stefan
- Haber Marc
- Hall Alistair S.
- Hall Leanne M.
- Hamsten Anders
- Han Bok-Ghee
- Harbaoui Brahim
- Harris Tamara B.
- Harvey Richard
- Hayes Sharonne N.
- Hazen Stanley L.
- Hengstenberg Christian
- Hofman Albert
- Holloway Cameron
- Hopewell Jemma C.
- Houpe David
- Huang Jianfeng
- Huang Jie
- Huang Siying
- Hwang Shih-Jen
- Iismaa Siiri E.
- Ingelsson Erik
- Iribarren Carlos
- Jalilzadeh Shapour
- Jeunemaitre Xavier
- Jouven Xavier
- Jukema J Wouter
- Kadian-Dodov Daniella
- Kanoni Stavroula
- Karhunen Pekka J.
- Karrillon Gaëtan
- Kathiresan Sekar
- Kessler Thorsten
- Kim Bong-Jo
- Kim Yun Kyoung
- Kleber Marcus E.
- Koning René
- Kooner Jaspal S.
- Kovacic Jason C.
- Kullo Iftikhar J.
- Kyriakou Theodosios
- König Inke R.
- Lannfelt Lars
- Lau King Wai
- Le Bivic Louis
- Lehtimäki Terho
- Lhermusier Thibault
- Lieb Wolfgang
- Lind Lars
- Lindgren Cecilia M.
- Lokki Maisa
- Loos Ruth J.
- Lu Xiangfeng
- Lu Yingchang
- Lyytikäinen Leo P.
- Magnusson Patrik K.
- Mallick Nadeem H.
- Manchuelle Aurélie
- Manzo-Silberman Stephane Peggy
- Margaritis Marios
- Marliere Stéphanie
- Mayaud Norbert
- Mazurkiewicz Stephani
- McGrath-Cadell Lucy
- McPherson Ruth
- Mehra Narinder
- Meitinger Thomas
- Melander Olle
- Memon Fazal-ur-Rehman
- Meneveau Nicolas
- Metspalu Andres
- Mihailov Evelin
- Mishra Ketan
- Monnier Arsène
- Morris Andrew P.
- Morrison Alanna
- Motreff Pascal
- Motreff Pascal
- Muller David
- März Winfried
- Nelson Christopher P.
- Nelson Christopher P.
- Nieminen Markku S.
- Nikpay Majid
- O'Byrne Megan M.
- O'Donnell Christopher J.
- Olin Jeffrey W.
- Olson Timothy M.
- Palmer Colin N.
- Pedersen Nancy L.
- Perola Markus
- Pervjakova Natalia
- Peters Annette
- Qu Liming
- Quertermous Thomas
- Rader Daniel J.
- Rallidis Loukianos S.
- Range Grégoire
- Rasheed Asif
- Reilly Muredach P.
- Ridker Paul M.
- Rioufol Gilles
- Ripatti Samuli
- Roberts Robert
- Rose Lynda M.
- Roule Vincent
- Saint-Etienne Christophe
- Saleheen Danish
- Salengro Emmanuel
- Salfati Elias
- Salomaa Veikko
- Samani Nilesh J.
- Samani Nilesh J.
- Samuel Maria
- Sanghera Dharambir K.
- Saxena Richa
- Scholz Markus
- Schunkert Heribert
- Schwartz Stephen M.
- Seedorf Udo
- Shah Svati H.
- Silvain Johanne
- Sinisalo Juha
- Smith Albert V.
- Spaulding Christian
- Stewart Alexandre F.
- Stirrups Kathleen E.
- Stott David J.
- Sweeting Michael
- Teiger Emmanuel
- Thiery Joachim
- Thompson John R.
- Tikkanen Emmi
- Trompet Stella
- Tweet Marysia S.
- Uitterlinden Andre
- Valla Mathieu
- Valy Yann
- van Zuydam Natalie R.
- Varenne Olivier
- Wang Laiyuan
- Watkins Hugh
- Webb Thomas R.
- Welch Catherine A.
- Willenborg Christina
- Won Hong-Hee
- Wong Claire Mei Yi
- Wood Alice
- Yang Xueli
- Zabalawi Amer
- Zalloua Pierre A.
- Zaman Khan S.
- Zeng Lingyao
- Zhang Weihua
- Zhao Wei
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.
Objectives:
This study sought to test the association between the rs9349379 genotype and SCAD.
Methods:
Results from case control studies from France, United Kingdom, United States, and Australia were analyzed to test the association with SCAD risk, including age at first event, pregnancy-associated SCAD (P-SCAD), and recurrent SCAD.
Results:
The previously reported risk allele for FMD (rs9349379-A) was associated with a higher risk of SCAD in all studies. In a meta-analysis of 1,055 SCAD patients and 7,190 controls, the odds ratio (OR) was 1.67 (95% confidence interval [CI]: 1.50 to 1.86) per copy of rs9349379-A. In a subset of 491 SCAD patients, the OR estimate was found to be higher for the association with SCAD in patients without FMD (OR: 1.89; 95% CI: 1.53 to 2.33) than in SCAD cases with FMD (OR: 1.60; 95% CI: 1.28 to 1.99). There was no effect of genotype on age at first event, P-SCAD, or recurrence.
Conclusions:
The first genetic risk factor for SCAD was identified in the largest study conducted to date for this condition. This genetic link may contribute to the clinical overlap between SCAD and FMD
Observatoire Vendéen indépendant des syndromes Coronarien aigus avec sus-décalage du segment ST (Registre OVISCA). Évaluation départementale, évolution démographique, mortalité, délais de prise en charge
- Author
- B. Zeninari
- Boivineau
- C. Boivineau
- C. Federspiel
- D. Lipp
- D. Mouhoub
- E. Boiffard
- E. Trebouet
- G. Haddad
- G. Turlotte
- H. Pouliquen
- Hanssen
- Haute Autorité de Santé
- Ibanez
- J. Dimet
- J.-L. Georges
- J.-O. Nguyen
- Koul
- L. Orion
- Loirat
- M. Charvet
- M. Flori
- M. Philippot
- Mehta
- Milojevitch
- N. Roy
- O. Baron
- O. Billon
- OESTV.
- P. Pernollet
- Puymirat
- Rangé
- T. Doizon
- Trebouet
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Calcium oxalate crystals inGeastrum
- Author
- A. C. Gentile
- D. Jones
- D. L. Hawksworth
- D. P. Maxwell
- Ernst Mrazek
- F. Austenfeld
- F. F. Nord
- F.-E. Eckblad
- G. Eberle
- G. Gross
- G. Scurfield
- H. Dissing
- H. D�rfelt
- H. Lohwag
- H. Lohwag
- H. Lohwag
- H.-H. Handke
- Irmgard Krisai
- J. B. McNair
- J. Boiffard
- J. F. L. M. Urbanus
- J. Keller
- J. Nitare
- L. Hollos
- M. Honrubia
- O. Monthoux
- O. Monthoux
- R. K�hner
- S. Fricke
- V. Demoulin
- V. J. Stan?k
- V. R. Franceschi
- W. C. Coker
- W. C. Graustein
- W. J�lich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1986
- Field of study
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
- Author
- Adlam D.
- Al-Hussaini A.
- Alver M.
- Anand S.S.
- Ardissino D.
- Armasu S.M.
- Assimes T.L.
- Aubry P.
- Auro K.
- Bali L.
- Barnay P.
- Bedossa M.
- Belle L.
- Benamer H.
- Bertram L.
- Beutner F.
- Bjonnes A.
- Boerwinkle E.
- Boiffard E.
- Borecki I.B.
- Bottinger E.P.
- Bouajila S.
- Bouatia-Naji N.
- Braund P.S.
- Bresson D.
- Brunel P.
- Buring J.E.
- Caussin C.
- Cayla G.
- Chambers J.C.
- Champin S.
- Chasman D.I.
- Chen S.
- Clarke R.
- Collins R.
- Combaret N.
- Commeau P.
- Cottin Y.
- Cupples L.A.
- d'Escamard V.
- Danesh J.
- de Andrade M.
- De Poli F.
- de Vries P.S.
- Dedoussis G.
- Dehghan A.
- Delarche N.
- Deloukas P.
- Demuth I.
- Dubreuil O.
- Ducrocq G.
- Dunwoodie S.L.
- Dupouy P.
- Elosua R.
- Empana J.-P.
- Epstein S.E.
- Erdmann J.
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- Farrall M.
- Fatkin D.
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- Fluttaz A.
- Ford I.
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- Publication venue
- Publication date
- 01/01/2019
- Field of study
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
European earthstars in Geastraceae (Geastrales, Phallomycetidae) – a systematic approach using morphology and molecular sequence data
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Presentation, care and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.
- Author
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- Skuladottir F Bjork
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- Spica G
- Spychaj J-C
- Srinivasan M
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- Stables R
- Stachura J
- Staigyte J
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- Staroverov I
- Steblovnik K
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- Sustersic M
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- Sutton J
- Szastok H
- Szygula J
- Szyszkowska A
- Tadevosyan M
- Taha H Salah Eldin
- Taleska B Zafirovska
- Taneja A
- Tapia V
- Tasar O
- Tasnic M
- Tavares J
- Taylor B
- Taylor T
- Tchetche D
- Teimouri-Jervekani Z
- Tello-Montoliu A
- Temple N
- Ten Berg J
- Teterina M
- Theobald T
- Thomas C
- Thomas H E
- Tibaut M
- Tierney C
- Timiras E
- Timóteo A T
- Tomoaia R
- Tomulic V
- Tonks L
- Toohie J
- Torbica A
- Torres S
- Torromeo C
- Torun A
- Totladze L
- Toulgaridis F
- Tousek F
- Trajkovic M
- Tralhão A
- Trim F
- Tripathy N
- Tsinopoulos G
- Tsognemekh B
- Tuncay B
- Tupare S
- Turnbull A
- Turner A
- Turner V
- Turney S
- Tutic M
- Twiss S
- Tycinska A
- Tyrovolas K
- Tzanis G
- Tzifos V
- Tzvetkov B
- Upegui M P Tobon
- Uscumlic A
- Usmiani T
- Utku O
- Uttley A
- Uuetoa T
- Uulu E Sultan
- Uzokov J
- Vahanian A
- Vailati L
- Van Caenegem O
- Van de Werf F
- Van Den Buijs D
- Van'T Hof A
- Vardanyan A
- Vargas C Mendez
- Varlot J
- Vavlukis M
- Vecherko V I
- Vendrametto F
- Vervaet P
- Ververeli C-L
- Vesic O
- Vidal P
- Vinod M
- Virbickiene A
- Viswanathan G
- Vizel R
- Volcescu A
- Volkova A L
- Vorobeva D
- Vucic R
- Wain J
- Wajid I
- Walker R
- Wallentin L
- Wanda I
- Ward T
- Warda H M
- Watkin R
- Weferling M
- Weidinger F
- Weidinger F
- Wells K
- Wells T
- Wester A
- Weston C
- Whyte A
- Widdows P
- Wiklo K
- Wilkinson A
- Wilkinson V
- Williams F
- Williams M
- Wilmshurst N
- Wilson A
- Wolter J-S
- Wouters S
- Wray G
- Wren L
- Wright J
- Wybraniec M
- Xuereb R G
- Xuereb Robert George
- Xuereb S
- Yadangi S
- Yagmur B
- Yanes G
- Yaseen I F
- Yashoman M
- Yildirim C
- Yildiz Ö
- Yin D Chan Pin
- Yonis A
- Young E
- Zachoval C
- Zagnoni S
- Zahran A
- Zaliunas R
- Zamorano J L
- Zapata P Sanchez
- Zaputovic L
- Zateyshchikov D
- Zeren G
- Zeymer U
- Zeymer U
- Zhanyshbekova N
- Zhukova N
- Zibounoumi N
- Zimbakov Z
- Ziubryte G
- Ziyrek M
- Zlatic N
- Zubova E
- Zventsova V
- Zvizdic F
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 03/02/2023
- Field of study
Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF). a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study
- Author
- Abe T.
- Abondio A.
- Adachi K.
- Adlbrecht C.
- Agnelli G.
- Aguilar M.
- Albert F.
- Algalarrondo V.
- Alings M.
- Alonso Martin M. C.
- Ameri P.
- Anguera Camos I.
- Anne W.
- Aradi D.
- Arnbas F.
- Auer J.
- Auricchio A.
- Awane K.
- Axelsson M.
- Ayata K.
- Balazsik D.
- Banik J.
- Bartels L.
- Bata I.
- Bayle S.
- Becattini C.
- Benak A.
- Bencze G.
- Benczur B.
- Benda M. A.
- Bensaid R.
- Berasi C.
- Berg J. C.
- Bergler-Klein J.
- Berglund S.
- Betsuyaku T.
- Billon O.
- Binsell E.
- Bioh G.
- Blier L.
- Bodor A.
- Boiffard E.
- Bolognese L.
- Borrego L.
- Borsanyi T.
- Bot P.
- Boughanmi H.
- Bridonneau V.
- Brixey R. D.
- Broccatelli B.
- Campos Garcia B.
- Caso V.
- Cermak O.
- Champagne J.
- Charlier F.
- Child N.
- Chollet L.
- Connolly S. J.
- Constance C.
- Cosmi F.
- Coufal Z.
- Couffon P.
- Cox J.
- Crljenica C.
- D'Orazio S.
- Danier I.
- Dasoveanu M.
- Daudin M.
- De Ceuninck M.
- de Groot J.
- de Vries T.
- Debruyne P.
- Dedek V.
- Delesie M.
- Demichili T.
- den Uijl D.
- Derndorfer M.
- Dewilde W.
- Dinarvand D.
- Dirmans I.
- Domenico Dallaglio P.
- Drasnar T.
- Dubuc M.
- Dujardin K.
- Durdil V.
- Durdil V.
- Dutoiu T.
- Duytschaever M.
- Dyrda K.
- Eber M.
- Ebner C.
- Ebrahimi R.
- Ector B.
- Eder V.
- El Mansour N.
- Elbaz M.
- Eliasson K.
- Engelen M.
- Erdei N.
- Extramiana F.
- Falc M.
- Ferreira Gonzalez I.
- Fox K. A. A.
- Frick M.
- Fukuda K.
- Furuya O.
- Gall C.
- Garcia Hernando V.
- Gersamija A.
- Ghigliotti G.
- Gingl Z.
- Gomez-Doblas J. J.
- Gonzales Matos C. E.
- Gorka H.
- Gorog D.
- Gorog D. A.
- Goto D.
- Gue Y.
- Guerra P.
- Guerra Ramos J. M.
- Guglielmi G.
- Gunstone A.
- Gupta D.
- Habon T.
- Haegeli L.
- Hagwall K.
- Hajos J.
- Hamana T.
- Hametner G.
- Hamon C.
- Hansone S.
- Hashimoto K.
- Hata Y.
- Heidbuchel H.
- Hengstenberg C.
- Hepp T.
- Herczeg S.
- Higashiue S.
- Hiramatsu N.
- Hiroe Y.
- Hnat T.
- Holek M.
- Hoppe U.
- Hornof J.
- Hubauer M.
- Huber D.
- Ichibori H.
- Inoue T.
- Intorp S.
- Ishida I.
- Itoh M.
- Iwanami Y.
- Iwane S.
- Jandik T.
- Janssens L.
- Jimenez J. R.
- Jirak P. M.
- Johansson L.
- Jones W. S.
- Kalnins A.
- Kanji R.
- Kapus J.
- Kapus K.
- Kasuga K.
- Kataoka S.
- Kauer F.
- Kawai H.
- Keijzers M.
- Keil C.
- Kelemen B.
- Kettner J.
- Khairy P.
- Khalil C.
- Kiss O.
- Kiss R.
- Kiss T.
- Kjellman B.
- Klincare D.
- Knecht S.
- Kojima S.
- Kokawa T.
- Kolbitsch T.
- Kollias G.
- Komooka M.
- Koopman P.
- Kotalczyk A.
- Kozlovska A.
- Kuhne M.
- Kuijper A.
- Kuroyanagi S.
- Lacaze J.
- Lam A.
- Laperche C.
- Lellouche N.
- Lichtenauer M.
- Limeres Freire J.
- Lind M.
- Lindholm C. -J.
- Linkova H.
- Linz D.
- Lip G.
- Loghin C.
- Lopez Grau M.
- Lotti R.
- Luescher D.
- Lundvall M.
- Mach F.
- Machler M.
- Macle L.
- Malati E.
- Manninger-Wunscher M.
- Marco A.
- Masumoto A.
- Matoltsy A.
- Matsumi H.
- Matsumoto T.
- Matsuo K.
- Matsuo K.
- Matsuura M.
- Mattiuzzo E.
- Maury P.
- Memtsas V.
- Mendez Zurita F. J.
- Menichelli D.
- Merkely B.
- Merlo A. C.
- Miette F.
- Mikulica M.
- Mirna M.
- Missault L.
- Miyata T.
- Moccetti T.
- Mogro Carranza J. M.
- Mohammad U.
- Molin F.
- Mondesert B.
- Monti C.
- Mooe T.
- Moreno Weidmann Z.
- Moriyama T.
- Mosconi M. G.
- Muiesan M. L.
- Muller C.
- Mundl H.
- Murohashi A.
- Mutschlechner B.
- Mutti C.
- Nagy L.
- Nakamura Y.
- Nakano S.
- Namdar M.
- Nault I.
- Neefs J.
- Nesti M.
- Neumann C.
- Nikaido A.
- Notaristefani C.
- Notarstefano P. G.
- O'Hara G.
- Oemrawsingh R.
- Oishi S.
- Okamoto S.
- Okamura B.
- Oldgren J.
- Olsson J.
- Onishi T.
- Paciaroni M.
- Pandzic S.
- Parato V. M.
- Paskova E.
- Pasotti E.
- Pastori D.
- Patel M. R.
- Perez Cabeza A.
- Petr R.
- Petrova I.
- Philippon F.
- Piccini J. P.
- Pignatelli P.
- Pisters R.
- Plourde B.
- Podpera I.
- Podperova M.
- Polgar B.
- Pontaga N.
- Pouliquen H.
- Pranno N.
- Preishuber E.
- Primus-Grabscheit C.
- Proost V.
- Purerfellner H.
- Quentin A.
- Rabai M.
- Racz B.
- Range G.
- Reichlin T.
- Reinholde I.
- Reitgruber D.
- Rickli H.
- Rivard L.
- Rodriguez Font E.
- Rohrer U.
- Romanova J.
- Rombouts H.
- Roosen J.
- Rossenbacker T.
- Rossi M.
- Rouffiac S.
- Roussel L.
- Roy D.
- Rozkova N.
- Saely C.
- Safro J.
- Saito K.
- Saito T.
- Sakakibara M.
- Salguero Bodes R.
- Sallo Z.
- Salvetti M.
- Santa J.
- Sarrazin J. -F.
- Sasaki A.
- Sawada T.
- Scarano M.
- Schaap J.
- Scherr D.
- Schgoer W.
- Schmalzer F.
- Schober A.
- Schoepfer H.
- Schonbauer R.
- Schratter A.
- Schwarzl J.
- Segers D.
- Selig J.
- Sellier R.
- Senior R.
- Shimane A.
- Shoda M.
- Sieghartsleitner S.
- Sime I.
- Simmen C.
- Sirakova A.
- Smid J.
- Socie P.
- Soderberg J.
- Sprenger L.
- Steinberg C.
- Stevenhagen J.
- Stirna V.
- Stojkovic S.
- Stuhlinger M.
- Sturmberger T.
- Svedberg N.
- Tadros R.
- Takabe T.
- Takahashi N.
- Takaya T.
- Takemoto T.
- Talajic M.
- Taldir G.
- Tamiya E.
- Taniguchi Y.
- Tavernier R.
- Teleznikovs A.
- Thebault C.
- Thibault B.
- Thuaire C.
- Thulin J.
- Tieleman R.
- Toth B.
- Toth K.
- Totsimon K.
- Tourigny J. C.
- Tsukamoto S.
- Tsukishiro Y.
- Tsukiyama Y.
- Tsunamoto H.
- Tukkie R.
- Turlotte G.
- Ueno H.
- Ueno T.
- Upite D.
- Urbini C.
- Uzu K.
- van den Bos E.
- van Es J.
- van Stipdonk T.
- Vanassche T.
- Vancura V.
- Vandekerckhove Y.
- Vankelecom B.
- Verdel G.
- Verhamme P.
- Vervoort G.
- Viethen T.
- Vijgen J.
- Vinolas Prat X.
- Wallen H.
- Watanabe M.
- Watanabe N.
- Weissova D.
- Willems R.
- Wittmer S.
- Wong Y. -K.
- Wouters N.
- Yamamoto H.
- Yamamoto S.
- Yamamoto S.
- Yamamoto T.
- Yamashita H.
- Yokoi K.
- Yoshida C.
- Zapeca J.
- Zedigh C.
- Zilahi Z.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is limited by bleeding concerns. Asundexian, a novel, oral small molecule activated coagulation factor XIa (FXIa) inhibitor, might reduce thrombosis with minimal effect on haemostasis. We aimed to determine the optimal dose of asundexian and to compare the incidence of bleeding with that of apixaban in patients with atrial fibrillation. Methods: In this randomised, double-blind, phase 2 dose-finding study, we compared asundexian 20 mg or 50 mg once daily with apixaban 5 mg twice daily in patients aged 45 years or older with atrial fibrillation, a CHA2DS2-VASc score of at least 2 if male or at least 3 if female, and increased bleeding risk. The study was conducted at 93 sites in 14 countries, including 12 European countries, Canada, and Japan. Participants were randomly assigned (1:1:1) to a treatment group using an interactive web response system, with randomisation stratified by whether patients were receiving a direct-acting oral anticoagulant before the study start. Masking was achieved using a double-dummy design, with participants receiving both the assigned treatment and a placebo that resembled the non-assigned treatment. The primary endpoint was the composite of major or clinically relevant non-major bleeding according to International Society on Thrombosis and Haemostasis criteria, assessed in all patients who took at least one dose of study medication. This trial is registered with ClinicalTrials.gov, NCT04218266, and EudraCT, 2019-002365-35. Findings: Between Jan 30, 2020, and June 21, 2021, 862 patients were enrolled. 755 patients were randomly assigned to treatment. Two patients (assigned to asundexian 20 mg) never took any study medication, resulting in 753 patients being included in the analysis (249 received asundexian 20 mg, 254 received asundexian 50 g, and 250 received apixaban). The mean age of participants was 73·7 years (SD 8·3), 309 (41%) were women, 216 (29%) had chronic kidney disease, and mean CHA2DS2-VASc score was 3·9 (1·3). Asundexian 20 mg resulted in 81% inhibition of FXIa activity at trough concentrations and 90% inhibition at peak concentrations; asundexian 50 mg resulted in 92% inhibition at trough concentrations and 94% inhibition at peak concentrations. Ratios of incidence proportions for the primary endpoint were 0·50 (90% CI 0·14–1·68) for asundexian 20 mg (three events), 0·16 (0·01–0·99) for asundexian 50 mg (one event), and 0·33 (0·09–0·97) for pooled asundexian (four events) versus apixaban (six events). The rate of any adverse event occurring was similar in the three treatment groups: 118 (47%) with asundexian 20 mg, 120 (47%) with asundexian 50 mg, and 122 (49%) with apixaban. Interpretation: The FXIa inhibitor asundexian at doses of 20 mg and 50 mg once daily resulted in lower rates of bleeding compared with standard dosing of apixaban, with near-complete in-vivo FXIa inhibition, in patients with atrial fibrillation. Funding: Bayer
Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry.
- Author
- Abdekader R
- Abdelhameed M
- Abdelhamid M
- Abdelmottaleb W
- Abdin A
- Abdrabou M
- Abid L
- Abraham J A
- Abraheem A
- Abras M
- Adam C
- Adamyan M
- Adel M
- Adlam D
- Aerts S
- Affleck D-C
- Afsar A
- Ageev F
- Aguiar C Tavares
- Ahangari F
- Ahmad W A Wan
- Ahmad Wan Azman Wan
- Ahmed A
- Ahmed A
- Ahmed F
- Ahmed I M
- Ahmed S
- Ahmed S Waqar
- Ailoaei S
- Akgun A
- Akhmatova F
- Akhtar N
- Al Mahmeed W A R
- Al Mahmeed Wael Abdul Rahman
- Al-Kinani T
- Al-Mashari S
- Al-Obaidi F
- Al-Riyami A
- Al-Riyami H
- Al-Zaidi M
- Alegre O
- Alemzadeh-Ansari M J
- Aleti S
- Algamal H Mahrous
- Alhussein F
- Ali A
- Ali H Hameed
- Ali M
- Ali M
- Ali T
- Ali Y
- Alla M Dafa
- Almeida A Rocha
- Almeida I
- Almeida S
- Almubarak E
- Almyahi M Hashim
- Alrahimi J
- Alsina M
- Altaher S
- Altinier A
- Alvarado K
- Alyavi A
- Alyavi B
- Alyavi Baxrom
- Amadi C
- Amber K
- Ambroziak M
- Amen S
- Amirov B
- Andrade L A Fajardo
- Andrei C-L
- Aneel A
- Anguita M J Fernandez
- Anselmi M
- Antonijevic J
- Antoniou A
- Antovski A
- Appelman Y
- Appelman Yolande
- Appelman Yolande
- Appelman Yolande
- Arat-Ozkan A
- Ardelean A
- Arefin M M
- Arefyev M N
- Argyropoulos K
- Ari H
- Ari S
- Ariza-Solé A
- Arizcuren A Munarriz
- Armangau P
- Arroyo-Monino D F
- Asim A
- Assaf O
- Assembekov B
- Astarcioglu M A
- Atallah B
- Atanaskovic V
- Atkinson C
- Atos J S
- Atta A Radi
- Attia N
- Augagneur M
- Avanzas P
- Averkov O V
- Avraamides P
- Ayesta A
- Aytekin V
- Aytekin Vedat
- Azam J
- Azam M G
- Azaryan K
- Azzahhafi J
- Babaeva L
- Babes E Emilia
- Babinski W
- Bacic G
- Badariene J
- Badri M
- Baglikov A
- Bahaa H
- Bahloul A
- Bahon L
- Bajramovic N Sabanovic
- Bajramovic Nirvana Sabanovic
- Baker P
- Bakr K
- Bakracheski N
- Baksyte G
- Balachandran K
- Balciute S
- Balghith M
- Balghith Mohammed
- Balparda H
- Baluta M M
- Ban E
- Banos J-L
- Baptista R
- Baptista S
- Barbato E
- Bardauskiene L
- Barillà F
- Barker J
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- Barman L
- Barrabes J A
- Bartoszewska D
- Basaran O
- Bashuroska E Kovacheska
- Basiero A Bonet
- Bastiancic L
- Batias-Moreau L
- Batin P
- Batjoens H
- Batrinac A
- Baydar O
- Bañeras J
- Beauloye C
- Beauloye Christophe
- Becker D
- Beckers J
- Bednarek A
- Beekes M
- Been M
- Beesley K
- Bega G
- Begic A
- Begic E
- Belahnech Y
- Beleslin B
- Belfiore R
- Bell S
- Beltrano C
- Benham L
- Benvenga R M
- Beranova M
- Bermúdez M Garcia
- Bernabò P
- Bernal F J Castillo
- Besli F
- Betiu A
- Betkier-Lipinska K
- Biccire F G
- Biddau M
- Birchall K
- Biria A
- Biron Y
- Biserka S
- Blachut A
- Black M
- Blasco A
- Blockmans M
- Blondelon A
- Boiffard E
- Bojovski I
- Bondare L
- Bonet G
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- Bonnet G
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- Bosch X
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- Brezeanu R
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- Brinkworth E
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- Brozmannová D
- Brozmannová Denisa
- Brugaletta Salvatore
- Brugaletta Salvatore
- Brunner P
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- Brust K
- Bs C
- Buckley C
- Buckman C
- Budaj A
- Budaj A
- Budaj A
- Budaj Andrzej
- Budaj Andrzej
- Budyak V
- Bueno H
- Bueno Hector
- Bueno Hector
- Bueno Héctor
- Bugajski J
- Burdeus M Vidal
- Burton J
- Busljetik O
- Bustinza I C Möller
- Buttigieg L-L
- Button H
- Buysse M
- Buzle A
- Cabeza M Martin
- Cacucci M
- Cader F A
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- Tsognemekh B
- Tuncay B
- Tupare S
- Turnbull A
- Turner A
- Turner V
- Turney S
- Tutic M
- Twiss S
- Tycinska A
- Tyrovolas K
- Tzanis G
- Tzifos V
- Tzvetkov B
- Upegui M P Tobon
- Uscumlic A
- Usmiani T
- Utku O
- Uttley A
- Uuetoa T
- Uulu E Sultan
- Uzokov J
- Vahanian A
- Vailati L
- Van Caenegem O
- Van de Werf F
- Van Den Buijs D
- Van'T Hof A
- Vardanyan A
- Vargas C Mendez
- Varlot J
- Vavlukis M
- Vecherko V I
- Vendrametto F
- Vervaet P
- Ververeli C-L
- Vesic O
- Vidal P
- Vinod M
- Virbickiene A
- Viswanathan G
- Vizel R
- Volcescu A
- Volkova A L
- Vorobeva D
- Vucic R
- Wain J
- Wajid I
- Walker R
- Wallentin L
- Wanda I
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- Weidinger F
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- Xuereb S
- Yadangi S
- Yagmur B
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- Yaseen I F
- Yashoman M
- Yildirim C
- Yildiz Ö
- Yin D Chan Pin
- Yonis A
- Young E
- Zachoval C
- Zagnoni S
- Zahran A
- Zaliunas R
- Zamorano J L
- Zapata P Sanchez
- Zaputovic L
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- Zeymer U
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- Zhanyshbekova N
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- Zibounoumi N
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- Ziubryte G
- Ziyrek M
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- Zvizdic F
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 13/12/2022
- Field of study
Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry
- Author
- Abdekader R.
- Abdelhameed M.
- Abdelhamid M.
- Abdelmottaleb W.
- Abdin A.
- Abdrabou M.
- Abid L.
- Abraham J. A.
- Abraheem A.
- Abras M.
- Abu Kassim Z.
- Adam C.
- Adamyan M.
- Adel M.
- Adlam D.
- Aerts S.
- Affleck D. -C.
- Afsar A.
- Ageev F.
- Aguiar Oliveira Rosa S.
- Ahangari F.
- Ahmad W. A. W.
- Ahmed A.
- Ahmed A.
- Ahmed F.
- Ahmed I. M.
- Ahmed S.
- Ailoaei S.
- Akgun A.
- Akhmatova F.
- Akhtar N.
- Al Karoudi R.
- Al Mahmeed W. A. R.
- Al Mulla A.
- Al Shaimaa A.
- Al-Kinani T.
- Al-Mashari S.
- Al-Obaidi F.
- Al-Riyami A.
- Al-Riyami H.
- Al-Zaidi M.
- Alaa El Din A.
- Alcalde Rodriguez O.
- Alegre O.
- Alemzadeh-Ansari M. J.
- Aleti S.
- Alhussein F.
- Ali A.
- Ali M.
- Ali T.
- Ali Y.
- Almeida I.
- Almeida S.
- Almubarak E.
- Alrahimi J.
- Alsina M.
- Altaher S.
- Altinier A.
- Alvarado K.
- Alyavi A.
- Alyavi B.
- Alyavi B.
- Amadi C.
- Amber K.
- Ambroziak M.
- Amen S.
- Amirov B.
- Andrei C. -L.
- Aneel A.
- Anselmi M.
- Antonijevic J.
- Antoniou A.
- Antovski A.
- Appelman Y.
- Arat-Ozkan A.
- Ardelean A.
- Arefn M. M.
- Arefyev M. N.
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- Ari H.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2023
- Field of study
Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management in clinical practice and outcomes against the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without ST-segment-elevation. Methods and results Consecutively hospitalised adult NSTEMI patients (n = 3620) were enrolled between 11 March 2019 and 6 March 2021, and individual patient data prospectively collected at 287 centres in 59 participating countries during a two-week enrolment period per centre. The registry collected data relating to baseline characteristics, major outcomes (inhospital death, acute heart failure, cardiogenic shock, bleeding, stroke/transient ischaemic attack, and 30-day mortality) and guideline-recommended NSTEMI care interventions: electrocardiogram pre- or in-hospital, prehospitalization receipt of aspirin, echocardiography, coronary angiography, referral to cardiac rehabilitation, smoking cessation advice, dietary advice, and prescription on discharge of aspirin, P2Y12 inhibition, angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB), beta-blocker, and statin. Conclusion The EORP NSTEMI Registry is an international, prospective registry of care and outcomes of patients treated for NSTEMI, which will provide unique insights into the contemporary management of hospitalised NSTEMI patients, compliance with ESC 2015 NSTEMI Guidelines, and identify potential barriers to optimal management of this common clinical presentation associated with significant morbidity and mortality