Jet diffuser for simulating ram conditions on a turbojet-engine static test stand

A jet diffuser for simulating flight or ram conditions on a turbojet-engine static test stand was designed and investigated. The diffuser utilizes the kinetic energy of the jet from a turbojet engine to reduce the discharge pressure at the exhaust nozzle and thereby provides simulated ram-pressure ratios across the engine. The engine exhaust nozzle discharges into an exhaust chamber (flexibly sealed to the tail pipe), which is connected to a diffuser by a bell-shaped nozzle. The pressure in the exhaust chamber is controlled independently of engine speed by a variable-area shutter at the diffuser discharge. The jet diffuser simulated ram-pressure ratios from 0.95 to 2.2 at various simulated pressure altitudes for a range of engine speeds from 85 to 100 percent of maximum rpm. Agreement of data obtained with and without the jet diffuser for a ram-pressure ratio of 1.0 indicated that the presence of the diffuser did not interfere with the flow through the engine exhaust-nozzle outlet

Biomechanical Dependence of SARS-CoV-2 Infections

Older people have been disproportionately vulnerable to the current SARS-CoV-2 pandemic, with an increased risk of severe complications and death compared to other age groups. A mix of underlying factors has been speculated to give rise to this differential infection outcome including changes in lung physiology, weakened immunity, and severe immune response. Our study focuses on the impact of biomechanical changes in lungs that occur as individuals age, that is, the stiffening of the lung parenchyma and increased matrix fiber density. We used hydrogels with an elastic modulus of 0.2 and 50 kPa and conventional tissue culture surfaces to investigate how infection rate changes with parenchymal tissue stiffness in lung epithelial cells challenged with SARS-CoV-2 Spike (S) protein pseudotyped lentiviruses. Further, we employed electrospun fiber matrices to isolate the effect of matrix density. Given the recent data highlighting the importance of alternative virulent strains, we included both the native strain identified in early 2020 and an early S protein variant (D614G) that was shown to increase the viral infectivity markedly. Our results show that cells on softer and sparser scaffolds, closer resembling younger lungs, exhibit higher infection rates by the WT and D614G variant. This suggests that natural changes in lung biomechanics do not increase the propensity for SARS-CoV-2 infection and that other factors, such as a weaker immune system, may contribute to increased disease burden in the elderly

Quantification of ETS exposure in hospitality workers who have never smoked

<p>Abstract</p> <p>Background</p> <p>Environmental Tobacco Smoke (ETS) was classified as human carcinogen (K1) by the German Research Council in 1998. According to epidemiological studies, the relative risk especially for lung cancer might be twice as high in persons who have never smoked but who are in the highest exposure category, for example hospitality workers. In order to implement these results in the German regulations on occupational illnesses, a valid method is needed to retrospectively assess the cumulative ETS exposure in the hospitality environment.</p> <p>Methods</p> <p>A literature-based review was carried out to locate a method that can be used for the German hospitality sector. Studies assessing ETS exposure using biological markers (for example urinary cotinine, DNA adducts) or questionnaires were excluded. Biological markers are not considered relevant as they assess exposure only over the last hours, weeks or months. Self-reported exposure based on questionnaires also does not seem adequate for medico-legal purposes. Therefore, retrospective exposure assessment should be based on mathematical models to approximate past exposure.</p> <p>Results</p> <p>For this purpose a validated model developed by Repace and Lowrey was considered appropriate. It offers the possibility of retrospectively assessing exposure with existing parameters (such as environmental dimensions, average number of smokers, ventilation characteristics and duration of exposure). The relative risk of lung cancer can then be estimated based on the individual cumulative exposure of the worker.</p> <p>Conclusion</p> <p>In conclusion, having adapted it to the German hospitality sector, an existing mathematical model appears to be capable of approximating the cumulative exposure. However, the level of uncertainty of these approximations has to be taken into account, especially for diseases with a long latency period such as lung cancer.</p

NACA Research Memorandums

Report presenting a theoretical analysis of thrust augment of turbojet engines by tail-pipe burning and charts from which the thrust augmentation produced may be evaluated from the normal engine data and performance of the tail-pipe burner. Results regarding general curves and illustrative curves are provided

NACA Technical Notes

Report presenting an investigation of a jet diffuser designed to utilize the kinetic energy of the jet from a turbojet engine to reduce discharge pressure at the exhaust nozzle and therefore provide simulated ram-pressure ratios across the engines and altitudes. Curves of performance data for a turbojet engine at several ram-pressure ratios show the range of engine operating conditions obtainable with the jet diffuser