Canonical D = 1 supergravity framework for FLRW cosmology

We construct an extension of standard flat FLRW cosmology with matter, possessing local D = 1, N = 1 proper-time supersymmetry. The fundamental equation for the resulting mini-superspace models of quantum universes is a Dirac-like analogue of the Friedmann and Wheeler-DeWitt equations. We provide solutions of this equation for specific matter configurations based on the supersymmetric O(3) and O(2, 1) sigma-models. It turns out that in the compact model the volume rate of growth of the universe is quantized and non-vanishing due to the zero-point energy of the scalar fields. In the non-compact model the spectrum of the growth rates is continuous but subject to an uncertainty relation involving the scale and the growth factor.Comment: 14 pages, no figure

Music and the Presidency: How Campaign Songs Sold the Image of Presidential Candidates

In this thesis, I will discuss the importance of campaign songs and how they were used throughout three distinctly different U.S. presidential elections: the 1960 campaign of Senator John Fitzgerald Kennedy against Vice President Richard Milhouse Nixon, the 1984 reelection campaign of President Ronald Wilson Reagan against Vice President Walter Frederick Mondale, and the 2008 campaign of Senator Barack Hussein Obama against Senator John Sidney McCain. In doing so, there will be an analysis of how music was used to sell the image of these presidential candidates through both its juxtaposition with other forms of mass media (television advertisements, radio, internet streaming platforms) and the content found in a song\u27s lyrics. There will be an apparent shift in focus from candidates using original campaign songs written for the purpose of elections, toward a more prominent reliance on popular music of current and past eras. From original and politically direct works such as I Like Ike and Click with Dick, to the campaign use of popular hits like Bruce Springsteen\u27s Born in the U.S.A. and Fleetwood Mac\u27s Don\u27t Stop, I will demonstrate how presidential candidates and their teams found it beneficial to use notable music works in order to connect with a younger generation of voters. In conclusion, the reader will have gained enough understanding to realize how campaign music continues to play a role in the current political climate, demonstrating how far candidates have taken the use of music over the past sixty years

Broad expertise retrieval in sparse data environments

Expertise retrieval has been largely unexplored on data other than the W3C collection. At the same time, many intranets of universities and other knowledge-intensive organisations offer examples of relatively small but clean multilingual expertise data, covering broad ranges of expertise areas. We first present two main expertise retrieval tasks, along with a set of baseline approaches based on generative language modeling, aimed at finding expertise relations between topics and people. For our experimental evaluation, we introduce (and release) a new test set based on a crawl of a university site. Using this test set, we conduct two series of experiments. The first is aimed at determining the effectiveness of baseline expertise retrieval methods applied to the new test set. The second is aimed at assessing refined models that exploit characteristic features of the new test set, such as the organizational structure of the university, and the hierarchical structure of the topics in the test set. Expertise retrieval models are shown to be robust with respect to environments smaller than the W3C collection, and current techniques appear to be generalizable to other settings

Using the VALGENT-3 framework to assess the clinical and analytical performance of the RIATOL qPCR HPV genotyping assay

Background and objective: The VALGENT framework is developed to assess the clinical performance of HPV tests that offer genotyping capability. Samples from the VALGENT-3 panel are used to identify an optimal viral concentration threshold for the RIATOL qPCR HPV genotyping assay (RIATOL qPCR) to assure non-inferior accuracy to detect high-grade cervical intraepithelial neoplasia (CIN), compared to Qiagen Hybrid Capture 2 (HC2), a standard comparator test validated for cervical cancer screening. Study design: The VALGENT-3 panel comprised 1300 samples from women participating in the Slovenian cervical cancer screening programme, enriched with 300 samples from women with abnormal cytology. In follow-up, 126 women were diagnosed with CIN2+ (defined as diseased) and 1167 women had two consecutive negative Pap smears (defined as non-diseased). All 1600 samples were analyzed with the RIATOL qPCR. Viral concentration was expressed as viral log10 of the number of copies/ml. A zone of viral concentration cut-offs was defined by relative ROC analysis where the sensitivity and specificity were not inferior to HC2. Results: The RIATOL qPCR had a sensitivity and specificity for CIN2+ of 97.6% (CI: 93.2-99.5%) and 85.1% (CI: 82.9-87.1%), respectively, when the analytical cut off was used. At a cut off of 6.5, RIATOL qPCR had a sensitivity of 96.0% (CI: 91.0-98.7%) and a specificity of 89.5% (87.6-91.2%). At optimized cut off, accuracy of the qPCR was non-inferior to the HC2 with a relative sensitivity of 1.00 [CI: 0.95-1.05 (p= 0.006)] and relative specificity of 1.00 [CI: 0.98-1.01 (p= 0.0069)]. Conclusions: The RIATOL qPCR has a high sensitivity and specificity for the detection of CIN2+. By using a fixed cut-off based on viral concentration, the test is non-inferior to HC2. HPV tests that provide viral concentration measurements or other quantifiable signals allow flexibility to optimize accuracy required for cervical cancer screening