294 research outputs found
Fisher Information for Inverse Problems and Trace Class Operators
This paper provides a mathematical framework for Fisher information analysis
for inverse problems based on Gaussian noise on infinite-dimensional Hilbert
space. The covariance operator for the Gaussian noise is assumed to be trace
class, and the Jacobian of the forward operator Hilbert-Schmidt. We show that
the appropriate space for defining the Fisher information is given by the
Cameron-Martin space. This is mainly because the range space of the covariance
operator always is strictly smaller than the Hilbert space. For the Fisher
information to be well-defined, it is furthermore required that the range space
of the Jacobian is contained in the Cameron-Martin space. In order for this
condition to hold and for the Fisher information to be trace class, a
sufficient condition is formulated based on the singular values of the Jacobian
as well as of the eigenvalues of the covariance operator, together with some
regularity assumptions regarding their relative rate of convergence. An
explicit example is given regarding an electromagnetic inverse source problem
with "external" spherically isotropic noise, as well as "internal" additive
uncorrelated noise.Comment: Submitted to Journal of Mathematical Physic
Correlator Bank Detection of GW chirps. False-Alarm Probability, Template Density and Thresholds: Behind and Beyond the Minimal-Match Issue
The general problem of computing the false-alarm rate vs. detection-threshold
relationship for a bank of correlators is addressed, in the context of
maximum-likelihood detection of gravitational waves, with specific reference to
chirps from coalescing binary systems. Accurate (lower-bound) approximants for
the cumulative distribution of the whole-bank supremum are deduced from a class
of Bonferroni-type inequalities. The asymptotic properties of the cumulative
distribution are obtained, in the limit where the number of correlators goes to
infinity. The validity of numerical simulations made on small-size banks is
extended to banks of any size, via a gaussian-correlation inequality. The
result is used to estimate the optimum template density, yielding the best
tradeoff between computational cost and detection efficiency, in terms of
undetected potentially observable sources at a prescribed false-alarm level,
for the simplest case of Newtonian chirps.Comment: submitted to Phys. Rev.
C-terminus of transcription factor TnrA from Bacillus subtilis controls DNA-binding domain activity but is not required for dimerization
The transcription factor TnrA, which belongs to the MerR transcription regulators, in Bacillus subtilis controls genes of nitrogen metabolism during nitrogen limiting conditions. As all the DNA-binding proteins, it is active as a dimer in cells, but the dimerization site is still unknown. The multiple alignment of TnrA homologs from other Bacilli allowed to identify the putative dimerization sites. Using the C-terminal truncated TnrA proteins it is established, that, in contrast to other MerR-proteins, the TnrA C-terminus does not participate in dimerization. Surface plasmon resonance has revealed that C-terminus truncations of TnrA do not inactivate its DNA-binding activity. Contrary, increased the affinity towards DNA, confirming that C-terminus controls the DNA-binding activity in a full-length TnrA. © 2013 Pleiades Publishing, Ltd
Generalized compactness in linear spaces and its applications
The class of subsets of locally convex spaces called -compact sets is
considered. This class contains all compact sets as well as several noncompact
sets widely used in applications. It is shown that many results well known for
compact sets can be generalized to -compact sets. Several examples are
considered.
The main result of the paper is a generalization to -compact convex sets
of the Vesterstrom-O'Brien theorem showing equivalence of the particular
properties of a compact convex set (s.t. openness of the mixture map, openness
of the barycenter map and of its restriction to maximal measures, continuity of
a convex hull of any continuous function, continuity of a convex hull of any
concave continuous function). It is shown that the Vesterstrom-O'Brien theorem
does not hold for pointwise -compact convex sets defined by the slight
relaxing of the -compactness condition. Applications of the obtained
results to quantum information theory are considered.Comment: 27 pages, the minor corrections have been mad
Bosonization method for second super quantization
A bosonic-fermionic correspondence allows an analytic definition of
functional super derivative, in particular, and a bosonic functional calculus,
in general, on Bargmann- Gelfand triples for the second super quantization. A
Feynman integral for the super transformation matrix elements in terms of
bosonic anti-normal Berezin symbols is rigorously constructed.Comment: In memoriam of F. A. Berezin, accepted in Journal of Nonlinear
Mathematical Physics, 15 page
Supersymmetry and LHC
The motivation for introduction of supersymmetry in high energy physics as
well as a possibility for supersymmetry discovery at LHC (Large Hadronic
Collider) are discussed. The main notions of the Minimal Supersymmetric
Standard Model (MSSM) are introduced. Different regions of parameter space are
analyzed and their phenomenological properties are compared. Discovery
potential of LHC for the planned luminosity is shown for different channels.
The properties of SUSY Higgs bosons are studied and perspectives of their
observation at LHC are briefly outlined.Comment: Lectures given at the 9th Moscow International School of Physics
(XXXIV ITEP Winter School of Physics
Thio derivatives of 2(5H)-furanone as inhibitors against Bacillus subtilis biofilms
© 2015 Park-media, Ltd. Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology. The gram-positive bacterium Bacillus subtilis is widely used as a model organism for studying biofilm formation. Here, we report on the effect of new synthesized 2(5H)-furanones on the biofilm formation by B.subtilis cells. Among 57 compounds tested, sulfur-containing derivatives of 2(5H)-furanone (F12, F15, and F94) repressed biofilm formation at a concentration of 10 μg/ml. Derivatives F12 and F94 were found to inhibit the biosynthesis of GFP from the promoter of the eps operon encoding genes of the biofilm exopolysaccharide synthesis (EPS). Using the differential fluorescence staining of alive/dead cells, we demonstrated an increased bacterial sensitivity to antibiotics (kanamycin and chloramphenicol) in the presence of F12, F15, and F94, with F12 being the most efficient one. The derivative F15 was capable of disrupting an already formed biofilm and thereby increasing the efficiency of antibiotics
Analysis of the archetypal functional equation in the non-critical case
We study the archetypal functional equation of the form (), where is a probability measure on ; equivalently, , where is expectation with respect to the distribution of random coefficients . Existence of non-trivial (i.e. non-constant) bounded continuous solutions is governed by the value ; namely, under mild technical conditions no such solutions exist whenever (and ) then there is a non-trivial solution constructed as the distribution function of a certain random series representing a self-similar measure associated with . Further results are obtained in the supercritical case , including existence, uniqueness and a maximum principle. The case with is drastically different from that with ; in particular, we prove that a bounded solution possessing limits at must be constant. The proofs employ martingale techniques applied to the martingale , where is an associated Markov chain with jumps of the form
Myectomy versus alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy
OBJECTIVES: There is very little evidence comparing the safety and efficacy of alcohol septal ablation versus septal myectomy for a septal reduction in patients with hypertrophic obstructive cardiomyopathy. This study aimed to compare the immediate and long-term outcomes of these procedures. METHODS: Following propensity score matching, we retrospectively analysed outcomes in 105 patients who underwent myectomy and 105 who underwent septal ablation between 2011 and 2017 at 2 reference centres. RESULTS: The mean age was 51.9 ± 14.3 and 52.2 ± 14.3 years in the myectomy and ablation groups, respectively (P = 0.855), and postoperative left ventricular outflow tract gradients were 13 (10-19) mmHg vs 16 (12-26) mmHg; P = 0.025. The 1-year prevalence of the New York Heart Association class III-IV was higher in the ablation group (none vs 6.4%; P = 0.041). The 5-year overall survival rate [96.8% (86.3-99.3) after myectomy and 93.5% (85.9-97.1) after ablation; P = 0.103] and cumulative incidence of sudden cardiac death [0% and 1.9% (0.5-7.5), respectively P = 0.797] did not differ between the groups. The cumulative reoperation rate within 5 years was lower after myectomy than after ablation [2.0% (0.5-7.6) vs 14.6% (8.6-24.1); P = 0.003]. Ablation was associated with a higher reoperation risk (subdistributional hazard ratio = 5.9; 95% confidence interval 1.3-26.3, P = 0.020). At follow-up, left ventricular outflow tract gradient [16 (11-20) vs 23 (15-59) mmHg; P < 0.001] and prevalence of 2+ mitral regurgitation (1.1% vs 10.6%; P = 0.016) were lower after myectomy than after ablation. CONCLUSIONS: Both procedures improved functional capacity; however, myectomy better-resolved classes III-IV of heart failure. Septal ablation was associated with higher reoperation rates. Myectomy demonstrated benefits in gradient relief and mitral regurgitation elimination. The results suggest that decreasing rates of myectomy procedures need to be investigated and reconsidered. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved
The monomer-dimer problem and moment Lyapunov exponents of homogeneous Gaussian random fields
We consider an "elastic" version of the statistical mechanical monomer-dimer
problem on the n-dimensional integer lattice. Our setting includes the
classical "rigid" formulation as a special case and extends it by allowing each
dimer to consist of particles at arbitrarily distant sites of the lattice, with
the energy of interaction between the particles in a dimer depending on their
relative position. We reduce the free energy of the elastic dimer-monomer (EDM)
system per lattice site in the thermodynamic limit to the moment Lyapunov
exponent (MLE) of a homogeneous Gaussian random field (GRF) whose mean value
and covariance function are the Boltzmann factors associated with the monomer
energy and dimer potential. In particular, the classical monomer-dimer problem
becomes related to the MLE of a moving average GRF. We outline an approach to
recursive computation of the partition function for "Manhattan" EDM systems
where the dimer potential is a weighted l1-distance and the auxiliary GRF is a
Markov random field of Pickard type which behaves in space like autoregressive
processes do in time. For one-dimensional Manhattan EDM systems, we compute the
MLE of the resulting Gaussian Markov chain as the largest eigenvalue of a
compact transfer operator on a Hilbert space which is related to the
annihilation and creation operators of the quantum harmonic oscillator and also
recast it as the eigenvalue problem for a pantograph functional-differential
equation.Comment: 24 pages, 4 figures, submitted on 14 October 2011 to a special issue
of DCDS-
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