462 research outputs found

    Aligning Instructional Practices and Direct Instruction to Improve the Social-Emotional Competencies of Students

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    The action research conducted was brought about by the researcher identifying a need to develop social-emotional skills due to the COVID-19 pandemic and subsequent shutdown of schools. Students in this research are in third grade in the researcher’s classroom. The research was conducted over two weeks. Students were given self-assessments to rate their scores. During the research, instructional practices were designed or utilized to match desired social-emotional competencies targeted through direct instruction. Findings from the research indicate that instructional practices aligned to social-emotional competencies grow the self-rated ability levels of students. The research conducted highlighted the need to provide opportunities for students to practice social-emotional competencies targeted during direct instruction

    Veevoer duurder maar veiliger

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    De opkomst van een biobased economy zal gevolgen hebben voor de veevoederindustrie. Reststromen die nu worden verwerkt tot voer voor koeien, kippen en varkens, verdwijnen in de toekomst mogelijk in de energieproductie of als grondstof voor andere industriële processen. Maar voor riskante afvalstromen ontstaat misschien een nieuwe mark

    CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis

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    The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules. Since the acrosome reaction resembles Ca(2+)-regulated exocytosis in neurons, we investigated whether cognate neuronal binding partners of the multi-PDZ domain protein MUPP1, which recruits molecules that control the initial tethering and/or docking between the acrosomal vesicle and the plasma membrane, are also expressed in spermatozoa, and whether they contribute to the regulation of acrosomal secretion. We observed that CaMKIIalpha colocalizes with MUPP1 in the acrosomal region of epididymal spermatozoa where the kinase selectively binds to a region encompassing PDZ domains 10-11 of MUPP1. Furthermore, we found that pre-treating mouse spermatozoa with a CaMKII inhibitor that directly blocks the catalytic region of the kinase, as well as a competitive displacement of CaMKIIalpha from PDZ domains 10-11, led to a significant increase in spontaneous acrosomal exocytosis. Since Ca(2+)-calmodulin releases CaMKIIalpha from the PDZ scaffolding protein, MUPP1 represents a central signaling platform to dynamically regulate the assembly and disassembly of binding partners pertinent to acrosomal secretion, thereby precisely adjusting an increase in Ca(2+) to synchronized fusion pore formation

    John F. Fallon, PhD: Fifty years of excellence in limb research and counting

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    No abstractPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83770/1/22594_ftp.pd

    Impact of herbivores on nitrogen cycling:contrasting effects of small and large species

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    Herbivores are reported to slow down as well as enhance nutrient cycling in grasslands. These conflicting results may be explained by differences in herbivore type. In this study we focus on herbivore body size as a factor that causes differences in herbivore effects on N cycling. We used an exclosure set-up in a floodplain grassland grazed by cattle, rabbits and common voles, where we subsequently excluded cattle and rabbits. Exclusion of cattle lead to an increase in vole numbers and a 1.5-fold increase in net annual N mineralization at similar herbivore densities (corrected to metabolic weight). Timing and height of the mineralization peak in spring was the same in all treatments, but mineralization in the vole-grazed treatment showed a peak in autumn, when mineralization had already declined under cattle grazing. This mineralization peak in autumn coincides with a peak in vole density and high levels of N input through vole faeces at a fine-scale distribution, whereas under cattle grazing only a few patches receive all N and most experience net nutrient removal. The other parameters that we measured, which include potential N mineralization rates measured under standardized laboratory conditions and soil parameters, plant biomass and plant nutrient content measured in the field, were the same for all three grazing treatments and could therefore not cause the observed difference. When cows were excluded, more litter accumulated in the vegetation. The formation of this litter layer may have added to the higher mineralization rates under vole grazing, through enhanced nutrient return through litter or through modification of microclimate. We conclude that different-sized herbivores have different effects on N cycling within the same habitat. Exclusion of large herbivores resulted in increased N annual mineralization under small herbivore grazin

    Reports on the Walnut Creek Watershed monitoring project, Jasper County, Iowa : water years 1995-2000

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    https://ir.uiowa.edu/igs_tis/1045/thumbnail.jp

    Bildung braucht RĂ€ume

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    BeitrĂ€ge zu der von der Arbeitsgruppe PĂ€dagogik und Architektur veranstalteten Tagung "Akustik und LĂ€rmbelastung in Kitas und Schulen" im Forum der Ostfriesischen Landschaft in Aurich. Die BeitrĂ€ge der Publikation thematisieren die Notwendigkeiten und Perspektiven eines systematisch(er)en Zusammenwirkens von PĂ€dagogik und Architektur in Kita und Schule am Beispiel Akustik und LĂ€rmbelĂ€stigung in institutionalisierten Bildungssettings fĂŒr Kinder und Jugendliche

    Feed or fuel : biofuels en effecten op de kwaliteit en beschikbaarheid van diervoedergrondstoffen in Nederland

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    Door de actuele ontwikkelingen op gebied van de biobased economy ontstaan nieuwe kansen voor het ministerie van LNV om te sturen op integrale kwaliteitscriteria en certificering voor alle organische grondstoffen (biomassa voor energie, veevoer, afval). De noodzaak om de kwaliteit van nieuwe reststromen in kaart te brengen en emerging risks systematisch te identificeren (o.a. effecten van gebruik nieuwe reststromen) is onveranderd groo

    RARE-01: Cerebral infarction in childhood-onset craniopharyngioma patients: results of KRANIOPHARYNGEOM 2007 [Abstract]

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    BACKGROUND: Cerebral infarction (CI) is a known vascular complication following treatment of suprasellar tumors. Risk factors for CI, incidence rate, and long-term prognosis are unknown for patients with childhood-onset craniopharyngioma (CP). METHODS: MRI of 244 CP patients, recruited between 2007 and 2019 in KRANIOPHA-RYNGEOM 2007, were reviewed for CI. Risk factors for CI and outcome after CI were analyzed. RESULTS: Twenty-eight of 244 patients (11%) presented with CI based on reference assessment of MRI. One CI occurred before initial surgery and one case of CI occurred after release of intracystic pressure by a cyst catheter. 26 of 28 CI were detected after surgical tumor resection at a median postoperative interval of one day (range: 0.5 - 53 days). Vascular lesions during surgical procedures were documented in 7 cases with CI. No relevant differences with regard to surgical approaches were found. In all 12 irradiated patients, CI occurred before irradiation. Multivariable analyses showed that hydrocephalus and gross-total resection at the time of primary diagnosis / surgery both were risk factors for CI. After CI, quality of life (PEDQOL) and functional capacity (FMH) were impaired. CONCLUSIONS: CI occurs in 11% of surgically-treated CP cases. Degree of resection and increased intracranial pressure are risk factors, which should be considered in the planning of surgical procedures for prevention of CI
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