1,182 research outputs found
Long-lived spin coherence in silicon with an electrical spin trap readout
Journal ArticlePulsed electrically detected magnetic resonance of phosphorous (31P) in bulk crystalline silicon at very high magnetic fields (B0 > 8:5 T) and low temperatures (T = 2:8 K) is presented. We find that the spin-dependent capture and reemission of highly polarized (>95%) conduction electrons by equally highly polarized 31P donor electrons introduces less decoherence than other mechanisms for spin-to-charge conversion. This allows the electrical detection of spin coherence times in excess of 100 ÎĽs, 50 times longer than the previous maximum for electrically detected spin readout experiments
Electrical detection of 31P spin quantum states
In recent years, a variety of solid-state qubits has been realized, including
quantum dots, superconducting tunnel junctions and point defects. Due to its
potential compatibility with existing microelectronics, the proposal by Kane
based on phosphorus donors in Si has also been pursued intensively. A key issue
of this concept is the readout of the P quantum state. While electrical
measurements of magnetic resonance have been performed on single spins, the
statistical nature of these experiments based on random telegraph noise
measurements has impeded the readout of single spin states. In this letter, we
demonstrate the measurement of the spin state of P donor electrons in silicon
and the observation of Rabi flops by purely electric means, accomplished by
coherent manipulation of spin-dependent charge carrier recombination between
the P donor and paramagnetic localized states at the Si/SiO2 interface via
pulsed electrically detected magnetic resonance. The electron spin information
is shown to be coupled through the hyperfine interaction with the P nucleus,
which demonstrates the feasibility of a recombination-based readout of nuclear
spins
Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated. We evaluated the effects of Gal-1 on eosinophil function and its role in a mouse model of allergic asthma. Allergen exposure resulted in airway recruitment of Gal-1-expressing inflammatory cells, including eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs. In vitro, extracellular Gal-1 exerted divergent effects on eosinophils that were N-glycan- And dose-dependent. At concentrations ≤0.25 ÎĽM, Gal-1 increased eosinophil adhesion to vascular cell adhesion molecule-1, caused redistribution of integrin CD49d to the periphery and cell clustering, but inhibited ERK(1/2) activation and eotaxin-1-induced migration. Exposure to concentrations ≥1 ÎĽM resulted in ERK(1/2)- dependent apoptosis and disruption of the F- Actin cytoskeleton. At lower concentrations, Gal-1 did not alter expression of adhesion molecules (CD49d, CD18, CD11a, CD11b, L-selectin) or of the chemokine receptor CCR3, but decreased CD49d and CCR3 was observed in eosinophils treated with higher concentrations of this lectin. In vivo, allergen-challenged Gal-1-deficient mice exhibited increased recruitment of eosinophils and CD3+ T lymphocytes in the airways as well as elevated peripheral blood and bone marrow eosinophils relative to corresponding WT mice. Further, these mice had an increased propensity to develop airway hyperresponsiveness and displayed significantly elevated levels of TNF-α in lung tissue. This study suggests that Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil apoptosis.Fil: Ge, Xiao Na. University of Minnesota; Estados UnidosFil: Ha, Sung Gil. University of Minnesota; Estados UnidosFil: Greenberg, Yana G.. University of Minnesota; Estados UnidosFil: Rao, Amrita. University of Minnesota; Estados UnidosFil: Bastan, Idil. University of Minnesota; Estados UnidosFil: Blidner, Ada Gabriela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa y Medicina Experimental. FundaciĂłn de Instituto de BiologĂa y Medicina Experimental. Instituto de BiologĂa y Medicina Experimental; ArgentinaFil: Rao, Savita P.. University of Minnesota; Estados UnidosFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa y Medicina Experimental. FundaciĂłn de Instituto de BiologĂa y Medicina Experimental. Instituto de BiologĂa y Medicina Experimental; ArgentinaFil: Sriramarao, P.. University of Minnesota; Estados Unido
Sex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample.
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US.
METHODS: Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs.
RESULTS: There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24.7%) patients were evaluated at a PSC. A little over half of the patients evaluated at PSCs were female (53.8%). A lower proportion of women than men received rt-PA at both PSCs (6.8 vs. 7.5%, p \u3c 0.001) and non-PSCs (2.3 vs. 2.8%, p \u3c 0.001). After adjustment for potential confounders the odds of being treated with rt-PA remained lower for women regardless of presentation to a PSC (OR 0.87, 95% CI 0.81-0.94) or non-PSC (OR 0.88, 95% CI 0.82-0.94). After stratifying by sex and race, the lowest absolute treatment rates were observed in black women (4.4% at PSC, 1.9% at non-PSC). The odds of treatment, relative to white men, was however lowest for white women (PSC OR = 0.85, 95% CI 0.78-0.93; non-PSC OR = 0.80, 95% CI 0.75-0.85). In the multivariable model, sex did not modify the effect of PSC certification on rt-PA utilization (p-value for interaction = 0.58).
CONCLUSION: Women are less likely to receive rt-PA than men at both PSCs and non-PSCs. Absolute treatment rates are lowest in black women, although the relative difference in men and women was greatest for white women
Morphology effects on spin-dependent transport and recombination in polyfluorene thin films
We have studied the role of spin-dependent processes on conductivity in
polyfluorene (PFO) thin films by conducting continuous wave (c.w.) electrically
detected magnetic resonance (EDMR) spectroscopy at temperatures between 10 K
and 293 K using microwave frequencies between about 100 MHz and 20 GHz as well
as pulsed EDMR at X-band. Variable frequency EDMR allows us to establish the
role of spin-orbit coupling in spin-dependent processes, pulsed EDMR probes
coherent spin motion effects. We used PFO for this study in order to allow for
the investigation of the effects of microscopic morphological ordering since
this material can adopt two distinct intrachain morphologies: an amorphous
(glassy) phase, and an ordered (beta) phase. In thin films of organic
light-emitting diodes (OLEDs) the appearance of a particular phase can be
controlled by deposition parameters, and is verified by electroluminescence
spectroscopy. We conducted multi-frequency c.w. EDMR, electrically detected
Rabi spinbeat experiments, Hahn-echo and inversion-recovery measurements.
Coherent echo spectroscopy reveals electrically detected electron spin-echo
envelope modulation (ESEEM) due to the precession of the carrier spins around
the protons. Our results demonstrate that while conformational disorder can
influence the observed EDMR signals, including the sign of the current changes
on resonance as well as the magnitudes of local hyperfine fields and charge
carrier spin-orbit interactions, it does not qualitatively affect the nature of
spin-dependent transitions in this material. At 293 K and 10 K, polaron-pair
recombination through weakly spin-spin coupled intermediate charge carrier pair
states is dominant, while at low temperatures, additional signatures of
spin-dependent charge transport through the interaction of polarons with
triplet excitons are seen in the half-field resonance of a triplet spin-1
species.Comment: 27 pages, 2 tables, 11 figures, full abstract in articl
Microfluidic synthesis of monodisperse and size-tunable CsPbBr3 supraparticles
The highly controlled, microfluidic template-assisted self-assembly of CsPbBr3 nanocrystals into spherical supraparticles is presented, achieving precise control over average supraparticle size through the variation of nanocrystal concentration and droplet size; thus facilitating the synthesis of highly monodisperse, sub-micron supraparticles (with diameters between 280 and 700 nm)
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