No Accounting for Culture? Value in the New Economy

This paper explores the articulation of the value of investment in culture and the arts through a critical discourse analysis of policy documents, reports and commentary since 1997. It argues that in this period discourses around the value of culture have moved from the direct economic contributions of the culture industries to indirect economic benefits. These indirect benefits are discussed under three main headings: creativity and innovation, employability and social inclusion. These in turn are analysed in terms of three forms of capital: human, social and cultural. The paper concludes with an analysis of this discursive shift through the lens of autonomist Marxist concerns with the labour of social reproduction. It is our argument that, in contemporary policy discourses on culture and the arts, that government in the UK is increasingly concerned with the use of culture to form the social in the image of capital. As such we have to turn our attention beyond the walls of the factory in order to understand the contemporary capitalist production of value

The New 'Hidden Abode': Reflections on Value and Labour in the New Economy

This paper engages with the works of Autonomist Marxists, such as Hardt, Negri and Arvidsson, who have argued that the so-called ‘new economy’, which is characterized by a new importance of immaterial labour, knowledge and processes of consumption, gives rise to a new law of value and changed labour relations in what they call the ‘social factory’. While we see a lot of value in this emerging body of literature – particularly in terms of its potential for critiquing relatively narrow debates in critical organization and management studies – this paper critiques the highly optimistic analyses put forward by Hardt, Negri and Arvidsson, especially with regard to their claims for a new autonomy and freedom of labour emerging out of the ‘new economy’. We counter these claims by showing how in contemporary capitalism, despite the discourses of autonomy and freedom, labour is continuously subjected to control, measurement and governance

A weighty interpretation of the Galactic Centre excess

Previous attempts at explaining the gamma-ray excess near the Galactic Centre have focussed on dark matter annihilation directly into Standard Model particles. This results in a preferred dark matter mass of 30-40 GeV (if the annihilation is into b quarks) or 10 GeV (if it is into leptons). Here we show that the gamma-ray excess is also consistent with heavier dark matter particles; in models of secluded dark matter, dark matter with mass up to 76 GeV provides a good fit to the data. This occurs if the dark matter first annihilates to an on-shell particle that subsequently decays to Standard Model particles through a portal interaction. This is a generic process that works in models with annihilation, semi-annihilation or both. We explicitly demonstrate this in a model of hidden vector dark matter with an SU(2) gauge group in the hidden sector.Comment: 5 pages, 4 figures. v2: Matches PRD version. Note: title of PRD version is "Interpretation of the Galactic Center excess of gamma rays with heavier dark matter particles

From Myth to Meth: Viewing the American Small Town Through the Lens of Psychoanalytica Fantasy

Simultaneously a symbol for benevolent hospitality and hostile insularity, the American small town and its surrounding rural areas have assumed many faces and forms in both filmic and literary representations over the last hundred years. Whereas the metropolis carries with it a specific history and culture that is known, at least in part, by an audience, the small-town, with all its stereotypical associations, lacks an analogous geographical and historical specificity. As a result of this relative anonymity, the small town often becomes a blank canvas onto which a number of conflicting representations can be painted. Despite significant differences in historical, geographical, and cultural markers that distinguish the real differences between small towns and rural areas, a certain corpus of social and moral values, as well as social and moral transgressions, emerge in association with the small town that often supersede these differences. Deployed for ideological purposes, the small town becomes less a specific place than it is an abstract concept that quilts social, political, and historical discourses together through the values or social problems they come to represent. Psychoanalysis, particularly the work of Slavoj iek, will be particularly important for examining the fantasmic and ideological uses of the small-town as a floating signifier that can mean anything when deployed for specific discursive purposes. From nostalgic representations of the small town as the place of some original harmony to the rural area as a sight of the most horrific of actions, the country is an interstitial repository, somewhere between the untamed wild and the civilized city, where both idealistic and obscene fantasies can play out because they take place out there uncoupled from the influences and transformations of social progress

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice

Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects. Furthermore, with the proliferation of cannabis use, modes of consumption are changing, with edible formulations becoming increasingly popular. Nevertheless, there are relatively few animal models of self-administration of the primary psychoactive component of cannabis, Δ9-tetrahydrocannabinol (THC), and almost all incorporate routes of administration other than those used by humans. The aim of the current study was to develop a model of edible THC self-administration and assess its impact on CB1 receptor-mediated behaviors in female and male mice. Methods Mice were given limited access to a palatable dough which occasionally contained THC in doses ranging from 1 to 10 mg/kg. Following dough consumption, mice were assessed for home cage locomotor activity, body temperature, or analgesia. Locomotor activity was also assessed in conjunction with the CB1 receptor antagonist SR141716A. Results Dough was well-consumed, but consumption decreased at the highest THC concentrations. Edible THC produced dose-dependent decreases in locomotor activity and body temperature in both sexes, and these effects were more pronounced in male mice. Hypolocomotion induced by edible THC was attenuated by SR141716A, indicating mediation by CB1 receptor activation. Conclusions In contrast to other cannabinoid self-administration models, edible THC is relatively low in stress and uses a route of administration analogous to one used by humans. Potential applications include chronic THC self-administration, determining THC reward/reinforcement, and investigating consequences of oral THC use

A Lower Bound on the Mass of Cold Thermal Dark Matter from Planck

We show that the new measurement of the effective number of neutrinos Neff by the Planck satellite can be used to set a robust lower bound on the mass of cold thermal dark matter of O(MeV). Our limit applies if the dark matter remains in thermal equilibrium by coupling to electrons and photons or through interactions with neutrinos, and applies regardless of whether the dark matter annihilation cross-section is s-wave or p-wave. To illustrate our bounds we apply them to a model of a supersymmetric neutralino annihilating to neutrinos, via a light mixed left-right handed sneutrino mediator. While this scenario was not constrained by previous data, the Planck limits on Neff allow us to set a lower bound on the neutralino dark matter mass of 3.5 MeV.Comment: 16 pages, 7 figures. v2: Added a comparison with BBN and new plots, updated references, typos corrected. v3: Matches version in jCA

A Prospective Study of Positive Psychological Well-Being and Coronary Heart Disease

Objective: Research suggests that positive psychological well-being is associated with cardiovascular health. However, much of this research uses elderly samples and has not determined the pathways by which psychological well-being influences cardiovascular disease or whether effects are similar for men and women. This study investigates the association between two aspects of well-being (emotional vitality and optimism) and coronary heart disease (CHD) in a sample of middle-aged men and women, and considers potential mediating factors. Method: Between 1991 and 1994, well-being and coronary risk factors were assessed among 7,942 individuals without a prior cardiovascular event from the Whitehall II cohort. Incident CHD (fatal CHD, first nonfatal myocardial infarction, or first definite angina) was tracked during 5 person-years of follow-up. Results: Positive psychological well-being was associated with reduced risk of CHD with an apparent threshold effect. Relative to people with the lowest levels of well-being, those with the highest levels had minimally adjusted hazard ratios of 0.74, 95% confidence interval [0.55, 0.98] for emotional vitality and 0.73, 95% confidence interval [0.54, 0.99] for optimism. Moreover, the association was strong for both genders and was only weakly attenuated when accounting for ill-being. Neither health-related behaviors nor biological factors explained these associations. Conclusions: Positive psychological well-being was associated with a modest, but consistent reduced risk of incident CHD. The relationship was comparable for men and women, and was maintained after controlling for cardiovascular risk factors and ill-being. Additional research is needed to identify underlying mechanisms and investigate whether interventions to increase well-being may enhance cardiovascular health

Slowing the onset of hypoxia increases colony forming efficiency of connective tissue progenitor cells \u3ci\u3ein vitro\u3c/i\u3e

Background: Survival and colony formation by transplanted tissue derived connective tissue progenitor cells (CTPs) are thought to be important factors in the success of clinical tissue engineering strategies for bone regeneration. Transplantation of cells into defects larger than a few millimeters expose cells to a profoundly hypoxic environment. This study tested the hypothesis that delaying the onset of hypoxia will improve the survival and performance of CTPs in vitro. Methods: To mimic declines seen in an avascular in vivo bone defect, colony forming efficiency by marrow derived nucleated cells was assessed under osteogenic conditions. Variation in the rate of oxygen decline from an oxygen tension of 21% to 0.1% oxygen was explored using an incubator with programmable active control of gas concentrations. The effect of doping cultures with defined concentrations of RBCs was also used to evaluate the potential for RBCs to serve as a natural buffer in the setting of declining oxygen levels. Results: A delay in onset of hypoxia over 96 hours resulted in a 3-fold increase in the relative colony forming efficiency (rCFE) of CTPs as compared to an immediate onset of hypoxia. The presence of RBCs in vitro inhibited the rCFE of CTPs. Given the negative effects of RBCs, methods of RBC removal were evaluated and compared for their effectiveness of RBC removal and retention of colony forming efficiency. Conclusions: These data suggest that conditions of hypoxia compromise colony forming efficiency in marrow derived CTPs. However, slowing the rate of decline of oxygen preserved colony forming efficiency at levels achieved in a stable normoxic (3% O2) environment. These data also suggest that RBCs are detrimental to the rCFE of CTPs and that buffy coat is an effective and preferred method for removing RBCs from marrow aspirates while preserving CTPs. These findings may inform clinical strategies for CTP transplantation

Quantifying proliferative and surface marker heterogeneity in colony‐founding connective tissue progenitors and their progeny using time‐lapse microscopy

Connective tissue progenitors (CTPs) are defined as the heterogeneous population of tissue‐resident stem and progenitor cells that are capable of proliferating and differentiating into connective tissue phenotypes. The prevalence and variation in clonal progeny of CTPs can be characterized using a colony formation assay. However, colony assays do not directly assess the characteristics of the colony‐founding CTP. We performed large, field‐of‐view, time‐lapse microscopy to manually track colonies back to the founding cells. Image processing and analysis was used to characterize the colonies and their founding cells. We found that the traditional colony‐forming unit (CFU) assay underestimates the number of founding cells as colonies can be formed by more than one founding cell. After 6 days in culture, colonies do not completely express CD73, CD90, and CD105. Heterogeneity in colony cells was characterized by two cell populations, proliferative and spread cells. Regression modelling of duration of lag phase and doubling time by cell marker suggests the presence of CD90 and CD105 in CTP subpopulations with different proliferative capabilities. From mathematical modelling of clonal colonies, we quantitatively characterized proliferation, migration, and cell marker expression rates to identify desirable clones for selection. Direct assessment of colony formation parameters led to more accurate assessment of CFU heterogeneity. Furthermore, these parameters can be used to quantify the diversity and hierarchy of stem and progenitor cells from a cell source or tissue for tissue engineering applications

Positive Health and Health Assets: Re-analysis of Longitudinal Datasets

Most approaches to health over the centuries have focused on the absence of illness. In contrast, we are investigating Positive Health —well-being beyond the mere absence of disease. In this article, we describe our theoretical framework and empirical work to date on Positive Health. Positive Health empirically identifies health assets by determining factors that predict health and illness over and above conventional risk factors. Biological health assets might include, for example, high heart rate variability, high levels of HDL, and cardiorespiratory fitness. Subjective health assets might include positive emotions, life satisfaction, hope, optimism, and a sense of meaning and purpose. Functional health assets might include close friends and family members; a stable marriage; meaningful work; participation in a social community; and the ability to carry out work, family, and social roles