Present Practice of Dynamite and Chemically Pure Glycerol Distillation

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An exercise in scientific method,

Thesis (M.A.)--Boston Universit

Performance of Solar-Assisted Modified-Open-Front Swine Nurseries

Performance data of two modified-open-front non-mechanically ventilated swine nurseries have shown that solar energy can be effectively utilized to maintain a productive environment within the animal space during cold weather (temperatures as low as -26°C ( - 15 °F). The nurseries feature a monoslope roof design and passive collector panels that also function as warm weather ventilation panels. An active solar-heating system uses a ground-level collector operated in conjunction with an in-floor solar heat distribution and storage system. The nurseries were designed to handle pigs weighing from 7 to 23 kg (15 to 50 lb). An average of 19% of the solar energy incident on the collector was transferred to the floor surface during the heating seasons from October 1980 to January 1982. Season heating costs were approximately 1.0% of the estimated cost to heat the nursery by conventional means

A STATISTICAL ANALYSIS OF THE PERFORMANCE OF MILKING SYSTEM VACUUM REGULATORS

Milking machine vacuum regulators were tested at dairies across the United States over a period of twelve years. The drop in vacuum level with increasing air flow for each regulator tested was modeled using segmented regression. Three measures of regulator performance were considered: the slope of the line in the first phase, the variability about the first line, and the join point (after which vacuum pressure began to drop rapidly). The distribution of the join point was estimated based on an accelerated failure time model with censoring, Weibull errors, a model effect, and a linear effect of set point vacuum. For each model, the average slope of the first line, the average variability about the line of the first regime, and the estimated median cfm (cubic feet of air per minute, New Zealand standard) for a join point with set point vacuum of 13 in. Hg were standardized. These standardized values were used in a cluster analysis to identify four performance groups of regulator models

Obturator externus abscess in a 9-year-old child: A case report and literature review.

Obturator pyomyositis is a rare condition in children. Diagnosis is often delayed because of its rarity, and the vagaries of its presentation cause it to be easily be missed. Physicians should therefore familiarize themselves with this condition and consider it as a possible differential diagnosis in patients presenting with an acutely painful hip. Inflammatory syndrome is also frequent among sufferers and the MRI is a very sensitive diagnostic tool for obturator pyomyositis. Additionally, joint fluid aspirations and blood cultures are also useful in identifying the pathogen. The appropriate antibiotic therapy provides a rapid regression of symptoms during the early stage of pyomyositis. In cases of MRI-confirmed abscess, surgical treatment is indicated. Our report focuses on a case of obturator pyomyositis in a 9-year-old boy. The child was febrile for 5 days and could only manage to walk a few steps. His hip range of motion was restricted in all directions. In addition, the patient had presented pain and swelling of his right elbow for a day, with a restriction of motion in the joint. There was a clear inflammatory syndrome. A diagnosis of hip and elbow septic arthritis was suspected, and the child underwent joint aspiration of the both cited joints. The aspiration of the elbow returned pus. Conversely, no effusion was found in the hip aspiration. The administration of empiric intravenous antibiotherapy was started. An MRI revealed an osteomyelitis of the ischio-pubic area associated with a subperiosteal abscess. Subsequently, 3 days after elbow arthrotomy, a surgical treatment was performed on the patient's right hip in order to evacuate the subperiosteal abscess and muscular collection because of the persistence of the patient's symptoms and inflammatory syndrome despite susceptible intravenous antibiotics. Postsurgery the patient showed steady improvement. Such cases demonstrate how diagnosis can be difficult because pelvic pyomyositis is often mistaken for more common pathologies such as septic arthritis, osteomyelitis, or appendicitis. This may delay the diagnosis or refer misdiagnosis. We discuss this rare infection in light of the literature with particular reference to its incidence, clinical features, bacteriological etiology, biological, and radiological presentation, and above all, its treatment

How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era.

The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus causing COVID-19 poses a global health challenge. There is remarkable progress in vaccine technology in response to this threat, but their design often overlooks the innate arm of immunity. Gamma Delta (γδ) T cells are a subset of T cells with unique features that gives them a key role in the innate immune response to a variety of homeostatic alterations, from cancer to microbial infections. In the context of viral infection, a growing body of evidence shows that γδ T cells are particularly equipped for early virus detection, which triggers their subsequent activation, expansion and the fast deployment of antiviral functions such as direct cytotoxic pathways, secretion of cytokines, recruitment and activation of other immune cells and mobilization of a trained immunity memory program. As such, γδ T cells represent an attractive target to stimulate for a rapid and effective resolution of viral infections. Here, we review the known aspects of γδ T cells that make them crucial component of the immune response to viruses, and the ways that their antiviral potential can be harnessed to prevent or treat viral infection

The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for Vδ2+ γδ T cells in the modulation of immune response to tumour?

Release of granulysin by γδ T cells contributes to tumour cell killing. A cytolytic 9kDa isoform of granulysin kills tumour cells directly, while a 15kDa precursor has been hypothesised to cause both the maturation and migration of dendritic cell (DC) populations. Recruiting DC to a tumour is beneficial as these cells initiate adaptive immune responses, which contribute to the eradication of malignancies. In this study, Vδ2+ γδ T cells were activated by stimulation of peripheral blood mononuclear cells (PBMC) with zoledronic acid (ZA) or Bacillus Calmette Guérin (BCG), or were isolated and cultured with tumour targets. While a large proportion of resting Vδ2+ γδ T cells expressed 15kDa granulysin, 9kDa granulysin expression was induced only after stimulation with BCG. Increased levels of activation and granulysin secretion were also observed when Vδ2+ γδ T cells were cultured with the human B cell lymphoma line Daudi. High concentrations of recombinant 15kDa granulysin caused migration and maturation of immature DC, and also initiated fugetaxis in mature DC. Conversely, low concentrations of recombinant 15kDa granulysin resulted in migration of mature DC, but not immature DC. Our data therefore support the hypothesis that Vδ2+ γδ T cells can release granulysin, which may modulate recruitment of DC, initiating adaptive immune responses