13,748 research outputs found

    Halofantrine

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    Studies on the bit rate requirements for a HDTV format with 1920 timestimes 1080 pixel resolution, progressive scanning at 50 Hz frame rate targeting large flat panel displays

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    This paper considers the potential for an HDTV delivery format with 1920 times 1080 pixels progressive scanning and 50 frames per second in broadcast applications. The paper discusses the difficulties in characterizing the display to be assumed for reception. It elaborates on the required bit rate of the 1080p/50 format when critical content is coded in MPEG-4 H.264 AVC Part 10 and subjectively viewed on a large, flat panel display with 1920 times 1080 pixel resolution. The paper describes the initial subjective quality evaluations that have been made in these conditions. The results of these initial tests suggest that the required bit-rate for a 1080p/50 HDTV signal in emission could be kept equal or lower than that of 2nd generation HDTV formats, to achieve equal or better image qualit

    The Phase Diagram and Spectrum of Gauge-Fixed Abelian Lattice Gauge Theory

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    We consider a lattice discretization of a covariantly gauge-fixed abelian gauge theory. The gauge fixing is part of the action defining the theory, and we study the phase diagram in detail. As there is no BRST symmetry on the lattice, counterterms are needed, and we construct those explicitly. We show that the proper adjustment of these counterterms drives the theory to a new type of phase transition, at which we recover a continuum theory of (free) photons. We present both numerical and (one-loop) perturbative results, and show that they are in good agreement near this phase transition. Since perturbation theory plays an important role, it is important to choose a discretization of the gauge-fixing action such that lattice perturbation theory is valid. Indeed, we find numerical evidence that lattice actions not satisfying this requirement do not lead to the desired continuum limit. While we do not consider fermions here, we argue that our results, in combination with previous work, provide very strong evidence that this new phase transition can be used to define abelian lattice chiral gauge theories.Comment: 42 pages, 30 figure

    The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers

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    A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons

    Composite infrared bolometers with Si_3N_4 micromesh absorbers

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    We report the design and performance of 300-mK composite bolometers that use micromesh absorbers and support structures patterned from thin films of low-stress silicon nitride. The small geometrical filling factor of the micromesh absorber provides 20× reduction in heat capacity and cosmic ray cross section relative to a solid absorber with no loss in IR-absorption efficiency. The support structure is mechanically robust and has a thermal conductance, G < 2 × 10^(−11) W/K, which is four times smaller than previously achieved at 300 mK. The temperature rise of the bolometer is measured with a neutron transmutation doped germanium thermistor attached to the absorbing mesh. The dispersion in electrical and thermal parameters of a sample of 12 bolometers optimized for the Sunyaev–Zel’dovich Infrared Experiment is ±7% in R (T), ±5% in optical efficiency, and ±4% in G

    Shocks in unmagnetized plasma with a shear flow: Stability and magnetic field generation

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    A pair of curved shocks in a collisionless plasma is examined with a two-dimensional particle-in-cell (PIC) simulation. The shocks are created by the collision of two electron-ion clouds at a speed that exceeds everywhere the threshold speed for shock formation. A variation of the collision speed along the initially planar collision boundary, which is comparable to the ion acoustic speed, yields a curvature of the shock that increases with time. The spatially varying Mach number of the shocks results in a variation of the downstream density in the direction along the shock boundary. This variation is eventually equilibrated by the thermal diffusion of ions. The pair of shocks is stable for tens of inverse ion plasma frequencies. The angle between the mean flow velocity vector of the inflowing upstream plasma and the shock's electrostatic field increases steadily during this time. The disalignment of both vectors gives rise to a rotational electron flow, which yields the growth of magnetic field patches that are coherent over tens of electron skin depths.Comment: 10 pages, 10 figures accepted for publication in Physics of Plasma

    Inferring the mass of submillimetre galaxies by exploiting their gravitational magnification of background galaxies

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    Dust emission at submillimetre wavelengths allows us to trace the early phases of star formation in the Universe. In order to understand the physical processes involved in this mode of star formation, it is essential to gain knowledge about the dark matter structures – most importantly their masses – that submillimetre galaxies live in. Here we use the magnification effect of gravitational lensing to determine the average mass and dust content of submillimetre galaxies with 250 μm flux densities of S_250 > 15 mJy selected using data from the Herschel Multi-tiered Extragalactic Survey. The positions of hundreds of submillimetre foreground lenses are cross-correlated with the positions of background Lyman-break galaxies at z ∼ 3–5 selected using optical data from the Canada–France–Hawaii Telescope Legacy Survey. We detect a cross-correlation signal at the 7σ level over a sky area of 1 deg^2, with ∼80 per cent of this signal being due to magnification, whereas the remaining ∼20 per cent comes from dust extinction. Adopting some simple assumptions for the dark matter and dust profiles and the redshift distribution enables us to estimate the average mass of the haloes hosting the submillimetre galaxies to be log _(10)[M_200/M_⊙] = 13.17^(+0.05)_(−0.08)(stat.) and their average dust mass fraction (at radii of >10 kpc) to be M_dust/M_200 ≈ 6 × 10^(−5). This supports the picture that submillimetre galaxies are dusty, forming stars at a high rate, reside in massive group-sized haloes and are a crucial phase in the assembly and evolution of structure in the Universe

    Chiral Fermions on the Lattice through Gauge Fixing -- Perturbation Theory

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    We study the gauge-fixing approach to the construction of lattice chiral gauge theories in one-loop weak-coupling perturbation theory. We show how infrared properties of the gauge degrees of freedom determine the nature of the continuous phase transition at which we take the continuum limit. The fermion self-energy and the vacuum polarization are calculated, and confirm that, in the abelian case, this approach can be used to put chiral gauge theories on the lattice in four dimensions. We comment on the generalization to the nonabelian case.Comment: 31 pages, 5 figures, two refs. adde

    Redshift Determination and CO Line Excitation Modeling for the Multiply Lensed Galaxy HLSW-01

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    We report on the redshift measurement and CO line excitation of HERMES J105751.1+573027 (HLSW-01), a strongly lensed submillimeter galaxy discovered in Herschel/SPIRE observations as part of the Herschel Multi-tiered Extragalactic Survey (HerMES). HLSW-01 is an ultra-luminous galaxy with an intrinsic far-infrared luminosity of L _(FIR) = 1.4 × 10^(13) L _⊙, and is lensed by a massive group of galaxies into at least four images with a total magnification of μ = 10.9 ± 0.7. With the 100 GHz instantaneous bandwidth of the Z-Spec instrument on the Caltech Submillimeter Observatory, we robustly identify a redshift of z = 2.958 ± 0.007 for this source, using the simultaneous detection of four CO emission lines (J = 7 → 6, J = 8 → 7, J = 9 → 8, and J = 10 → 9). Combining the measured line fluxes for these high-J transitions with the J = 1 → 0, J = 3 → 2, and J = 5 → 4 line fluxes measured with the Green Bank Telescope, the Combined Array for Research in Millimeter Astronomy, and the Plateau de Bure Interferometer, respectively, we model the physical properties of the molecular gas in this galaxy. We find that the full CO spectral line energy distribution is described well by warm, moderate-density gas with T _(kin) = 86-235 K and n_H_2 = (1.1-3.5)x10^3 cm^(–3). However, it is possible that the highest-J transitions are tracing a small fraction of very dense gas in molecular cloud cores, and two-component models that include a warm/dense molecular gas phase with T _(kin) ~ 200 K, n_H_2 ~ 10^5 cm^(–3) are also consistent with these data. Higher signal-to-noise measurements of the J _(up) ≥ 7 transitions with high spectral resolution, combined with high spatial resolution CO maps, are needed to improve our understanding of the gas excitation, morphology, and dynamics of this interesting high-redshift galaxy

    HerMES: deep number counts at 250 μm, 350 μm and 500 μm in the COSMOS and GOODS-N fields and the build-up of the cosmic infrared background

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    Aims. The Spectral and Photometric Imaging REceiver (SPIRE) onboard the Herschel space telescope has provided confusion limited maps of deep fields at 250 μm, 350 μm, and 500 μm, as part of the Herschel Multi-tiered Extragalactic Survey (HerMES). Unfortunately, due to confusion, only a small fraction of the cosmic infrared background (CIB) can be resolved into individually-detected sources. Our goal is to produce deep galaxy number counts and redshift distributions below the confusion limit at SPIRE wavelengths (~20 mJy), which we then use to place strong constraints on the origins of the cosmic infrared background and on models of galaxy evolution. Methods. We individually extracted the bright SPIRE sources (>20 mJy) in the COSMOS field with a method using the positions, the flux densities, and the redshifts of the 24 μm sources as a prior, and derived the number counts and redshift distributions of the bright SPIRE sources. For fainter SPIRE sources (<20 mJy), we reconstructed the number counts and the redshift distribution below the confusion limit using the deep 24 μm catalogs associated with photometric redshift and information provided by the stacking of these sources into the deep SPIRE maps of the GOODS-N and COSMOS fields. Finally, by integrating all these counts, we studied the contribution of the galaxies to the CIB as a function of their flux density and redshift. Results. Through stacking, we managed to reconstruct the source counts per redshift slice down to ~2 mJy in the three SPIRE bands, which lies about a factor 10 below the 5σ confusion limit. Our measurements place tight constraints on source population models. None of the pre-existing models are able to reproduce our results at better than 3-σ. Finally, we extrapolate our counts to zero flux density in order to derive an estimate of the total contribution of galaxies to the CIB, finding 10.1_(-2.3)^(+2.6) nW m^(-2) sr^(-1), 6.5_(-1.6)^(+1.7) nW m^(-2) sr^(-1), and 2.8_(-0.8)^(+0.9) nW m^(-2) sr^(-1) at 250 μm, 350 μm, and 500 μm, respectively. These values agree well with FIRAS absolute measurements, suggesting our number counts and their extrapolation are sufficient to explain the CIB. We find that half of the CIB is emitted at z = 1.04, 1.20, and 1.25, respectively. Finally, combining our results with other works, we estimate the energy budget contained in the CIB between 8 μm and 1000 μm: 26_(-3)^(+7) nW m^(-2) sr^(-1)
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