Introduction to the proceedings of the Piccola Impresa/Small Business 5th Workshop: “Beyond the crisis: what is the future for small businesses? Challenges, opportunities and lessons learned”

In this volume, we are pleased to present the proceedings of the 5th Workshop organised by the journal Piccola Impresa/Small Business in collaboration with the Association for the study of small enterprises (ASPI), the Research Center on Entrepreneurship and Small-medium firms (CRIMPI), the Italian Academy of Business Economics (AIDEA) and the European Council for Small Business and Entrepreneurship (ECSB). The workshop title was “Beyond the crisis: what is the future for small businesses? Challenges, opportunities and lessons learned”, and it took place online on December 4-5, 2021. The aim of the conference was to bring together scholars of entrepreneurship and small and medium-sized enterprises, to discuss the emerging issues following the Covid-19 pandemic. As we have highlighted in the call for papers of the workshop and a previous editorial published in the journal mentioned above (Pencarelli et al. 2021), the COVID-19 pandemic has triggered the largest public health crisis in living memory, with serious—and still unpredictable—consequences for the global economy. Available data clearly shows that SMEs have particularly suffered from economic downturn: their inherent weaknesses have amplified and accelerated the effects of the crisis compared to larger firms (Cowling et al., 2020; OECD, 2020). Notably, in Italy, the Covid-19 outbreak has challenged SMEs’ survival after a decade of a slow and incomplete recovery (CERVED, 2020, 2021)

Testing and evaluation of SURLYN foam and SPECTRA fiber ropes for buoy systems applications

Funding was provided by the Office of Naval Research through contract Number N00014-84-C-0134

Synergism through WEE1 and CHK1 inhibition in acute lymphoblastic leukemia

Introduction: Screening for synthetic lethality markers has demonstrated that the inhibition of the cell cycle checkpoint kinases WEE1 together with CHK1 drastically affects stability of the cell cycle and induces cell death in rapidly proliferating cells. Exploiting this finding for a possible therapeutic approach has showed efficacy in various solid and hematologic tumors, though not specifically tested in acute lymphoblastic leukemia. Methods: The efficacy of the combination between WEE1 and CHK1 inhibitors in B and T cell precursor acute lymphoblastic leukemia (B/T-ALL) was evaluated in vitro and ex vivo studies. The efficacy of the therapeutic strategy was tested in terms of cytotoxicity, induction of apoptosis, and changes in cell cycle profile and protein expression using B/T-ALL cell lines. In addition, the efficacy of the drug combination was studied in primary B-ALL blasts using clonogenic assays. Results: This study reports, for the first time, the efficacy of the concomitant inhibition of CHK1/CHK2 and WEE1 in ALL cell lines and primary leukemic B-ALL cells using two selective inhibitors: PF-0047736 (CHK1/CHK2 inhibitor) and AZD-1775 (WEE1 inhibitor). We showed strong synergism in the reduction of cell viability, proliferation and induction of apoptosis. The efficacy of the combination was related to the induction of early S-phase arrest and to the induction of DNA damage, ultimately triggering cell death. We reported evidence that the efficacy of the combination treatment is independent from the activation of the p53-p21 pathway. Moreover, gene expression analysis on B-ALL primary samples showed that Chek1 and Wee1 are significantly co-expressed in samples at diagnosis (Pearson r = 0.5770, p = 0.0001) and relapse (Pearson r= 0.8919; p = 0.0001). Finally, the efficacy of the combination was confirmed by the reduction in clonogenic survival of primary leukemic B-ALL cells. Conclusion: Our findings suggest that the combination of CHK1 and WEE1 inhibitors may be a promising therapeutic strategy to be tested in clinical trials for adult ALL

Effectiveness of cardiac resynchronization therapy in heart failure patients with valvular heart disease: comparison with patients affected by ischaemic heart disease or dilated cardiomyopathy. The InSync/InSync ICD Italian Registry

AimsTo analyse the effectiveness of cardiac resynchronization therapy (CRT) in patients with valvular heart disease (a subset not specifically investigated in randomized controlled trials) in comparison with ischaemic heart disease or dilated cardiomyopathy patients.Methods and resultsPatients enrolled in a national registry were evaluated during a median follow-up of 16 months after CRT implant. Patients with valvular heart disease treated with CRT (n = 108) in comparison with ischaemic heart disease (n = 737) and dilated cardiomyopathy (n = 635) patients presented: (i) a higher prevalence of chronic atrial fibrillation, with atrioventricular node ablation performed in around half of the cases; (ii) a similar clinical and echocardiographic profile at baseline; (iii) a similar improvement of LVEF and a similar reduction in ventricular volumes at 6-12 months; (iv) a favourable clinical response at 12 months with an improvement of the clinical composite score similar to that occurring in patients with dilated cardiomyopathy and more pronounced than that observed in patients with ischaemic heart disease; (v) a long-term outcome, in term of freedom from death or heart transplantation, similar to patients affected by ischaemic heart disease and basically more severe than that of patients affected by dilated cardiomyopathy.ConclusionIn 'real world' clinical practice, CRT appears to be effective also in patients with valvular heart disease. However, in this group of patients the outcome after CRT does not precisely overlap any of the two other groups of patients, for which much more data are currently available

Creazione di valore e canali di marketing: alcune riflessioni sull’industria del mobile

The aim of this paper is to describe the changes occurring in three furniture companies, Ikea, Febal and Scavolini in the customer value creation processes; the attempt is to emphasize how these processes can be better captured by a “representation” that is faraway from the traditional, “porterian” value-chain viewpoint and that we can call a value-network concept, bringing together different contributions in mainstream literature. In particular, this approach seems even more valid to catch the dynamics characterising the companies in relation to the marketing channels and distribution processes they are involved in. The opportunity to create a superior and new customer value depend more and more by an increasing number of actor, new activities and different resources; the emergence of the customer value results from downstream and upstream actors interacting simultaneously in each phase and bringing together different resources: competencies, skills, products, machines and information

The relationship between marketing and purchasing in business to business markets

The paper stresses the relevance of the relationship between marketing and purchasing in companies acting in business-to-business markets. The paper develops an analysis of business marketing and purchasing literature on the topic of the relationship between marketing and purchasing. Two pilot case studies are reported to enter into the detail of this relationship in companies. The aim is to understand the antecedents sub-standing marketing and purchasing relationships in companies and enter into the substance of such a relationship, into its benefits and problems