Termination of pre-trial investigation due to a serious illness of the suspect (accused) in the criminal procedure of Ukraine and some European states

The aim of the article is to study the legal regulations, doctrinal approaches to the understanding of mental disorder or another serious disease of the suspect (accused) as a reason for stopping the pre-trial investigation in the criminal procedural law of European countries, and also the development and justification of the proposal, directed for the improvement of the regulation of such reasons in the criminal procedural law of Ukraine. The methodological grounds of the research constitute general scientific and special legal methods, in particular dialectical, method of analysis, method of generalization, structural and functional method, hermeneutical method, dogmatic method, comparative legal method. We analyze one of the reasons for stopping the pre-trial investigation – mental disorder or another serious disease of the suspect (accused). Analyzing the corresponding legal acts of the CPC of Ukraine and European countries, the views of researchers, we provide our views on the questions of the research topic, and give suggestions on the improvement of the criminal procedural law of Ukraine. The signs of mental disorder of the suspect (accused) have been clarified, the criteria of the serious somatic symptom disorder as a reason for stopping the pre-trial investigation have been singled out.  A new version of P. 1 Ch. 1 Art. 280 of the CPC of Ukraine has been proposed

In vitro PKA phosphorylation-mediated human PDE4A4 activation

AbstractThe PDE4 catalytic machinery comprises, in part, two divalent cations in a binuclear motif. Here we report that PDE4A4 expressed in Sf9 cells exhibits a biphasic Mg2+ dose–response (EC50 of ∼0.15 and >10 mM) in catalyzing cAMP hydrolysis. In vitro phosphorylation of PDE4A4 by the PKA-catalytic subunit increases the enzyme’s sensitivity to Mg2+, leading to 4-fold increased cAMP hydrolysis without affecting its Km. The phosphorylation also increases the potencies of (R)- and (S)-rolipram without affecting CDP-840 and SB-207499. The results support that modulating the cofactor binding affinity of PDE4 represents a mechanism for regulating its activity

The Biomolecular Interaction Network Database and related tools 2005 update

The Biomolecular Interaction Network Database (BIND) (http://bind.ca) archives biomolecular interaction, reaction, complex and pathway information. Our aim is to curate the details about molecular interactions that arise from published experimental research and to provide this information, as well as tools to enable data analysis, freely to researchers worldwide. BIND data are curated into a comprehensive machine-readable archive of computable information and provides users with methods to discover interactions and molecular mechanisms. BIND has worked to develop new methods for visualization that amplify the underlying annotation of genes and proteins to facilitate the study of molecular interaction networks. BIND has maintained an open database policy since its inception in 1999. Data growth has proceeded at a tremendous rate, approaching over 100 000 records. New services provided include a new BIND Query and Submission interface, a Standard Object Access Protocol service and the Small Molecule Interaction Database (http://smid.blueprint.org) that allows users to determine probable small molecule binding sites of new sequences and examine conserved binding residues

Optimization of skeletal configuration: Studies of scoliosis correction biomechanics

A scheme for optimizing configurations in models of skeletal structures is presented. Use of the scheme is illustrated through determination of biomechanically optimal correction of a right-thoracic scoliosis by passive brace and active muscle forces. The locations and magnitudes of the passive brace forces, and the trunk muscle groups and their corresponding contraction intensity magnitudes that would optimally correct the geometric deformities of the spine were determined. The results suggest that, from a biomechanical viewpoint, both brace and muscle forces are capable of substantial correction of a model thoracic scoliosis. However, comparison of model results with long-term clinical results suggests that even under optimal conditions it is unlikely that scoliosis can be fully corrected by passive brace forces or active muscle contractions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29641/1/0000730.pd

Провадження в суді апеляційної та касаційної інстанції: чи відповідає назва глав 31 та 32 КИК України їхному змісту?

Бобечко Н. Р. Провадження в суді апеляційної та касаційної інстанції: чи відповідає назва глав 31 та 32 КИК України їхному змісту? / Н. Р. Бобечко // Правове життя сучасної України : матеріали Міжнар. наук. конф. проф.-викл. та аспірант. складу (м. Одеса, 16-17 травня 2013 р.) / відп. за вип. В. М. Дрьомін ; НУ "ОЮА". Півд. регіон. центр НАПрН України. - Одеса : Фенікс, 2013. - Т. 2. - С. 429-431