The Internet and the Law

The Internet and related technologies are impacting on the law like no other phenomenon in our lifetime. The impact is felt from the basic institutions of contract and tort to the remote corners of competition law and securities law. The legislative system is not coping with the challenge, as demonstrated by the paralysis over the Electronic Transactions Bill and the Crimes Amendment Bill (No 6). This article opens with some background material about the Internet, proceeds to consider its impact on eight areas of the law and concludes with some observations about the feasibility and direction of regulation

Family Business Interests under the Matrimonial Property and Companies Legislation An Introduction

This article is a preliminary investigation of family business interests under the Matrimonial Property Act 1976 ('MPA') and the Companies Act 1993 ('CA'). This article introduces the reader to the interrelationship of the matrimonial property regime and the legislative regulation of business entities, focusing on the implications of the MPA for the choice of entity, source of finance, division of shares, and allocation of management responsibility. Two principal lessons emerge from the authors' analysis: first, as applied to family ventures, the business entities legislation provides extensive flexibility with its ample allowance for contractual autonomy; and secondly, the matrimonial property regime is unsuitable for family structures involving a business operation. The authors conclude that the current regime for unmarried separate property, accessible by a MPA agreement under s 21, operates in a far more predictable manner and better suits the interests of many spouses.&nbsp

Demographic Shifts and Labour Force Participation Rates in Canada

Labour force participation rates vary greatly by age, with persons 55 and over having much lower participation rates than younger persons. Consequently, changes in the demographic composition of the population can exert a long-run effect on aggregate participation rates. In the third article of the symposium, Bob Dugan and Benoît Robidoux examine the impact of demographic shifts on labour force participation in Canada. They use an accounting framework and plausible trend participation rates for 16 demographic groups with source population estimates to estimate an aggregate structural participation rate for Canada. They find that the ageing of the population has already started to exert downward pressure on the aggregate participation rate in Canada due to longer life expectancy and the resulting growing proportion of the population in the low-participation rate 65 and over age group. The movement of the baby boom generation into the 65 and over group in coming years will intensify this trend. Between 1989 and 1997 they find that the demographic composition effect reduced the aggregate participation rate by almost 1 percentage point, and that from now to 2030 it will reduce the participation rate by an additional 8.5 points. Of course, greater than expected trend increases in labour force participation rates by older age groups could offset some of this composition effect. The authors point out that changes in demographic composition had virtually no effect on the participation rate in the 1990s in the United States as the share of the population 65 and over was stable. This situation reflects the fact that the United States became an “older” society earlier than Canada due to an earlier and smaller baby boom and a higher average age for immigrants. Dugan and Robidoux calculate a trend participation rate of 66.2 in 1997, 1.4 percentage points above the actual rate of 64.8 per cent. Based on this rate they conclude that about one half of the 2.7 point decline in the participation rate in the 1990s was structural and one half cyclical.Canada, Labour Force Participation, Labor Force Participation, Participation Rate, Labour Force Participation Rate, Labor Force Participation Rate, Age Structure, Age, Sex, Gender, Aging, Ageing

Knowledge-based systems and NASA's software support environment

A proposed role for knowledge-based systems within NASA's Software Support Environment (SSE) is described. The SSE is chartered to support all software development for the Space Station Freedom Program (SSFP). This includes support for development of knowledge-based systems and the integration of these systems with conventional software systems. In addition to the support of development of knowledge-based systems, various software development functions provided by the SSE will utilize knowledge-based systems technology

Phenomenology of the Little Higgs Model

We study the low energy phenomenology of the little Higgs model. We first discuss the linearized effective theory of the "littlest Higgs model" and study the low energy constraints on the model parameters. We identify sources of the corrections to low energy observables, discuss model-dependent arbitrariness, and outline some possible directions of extensions of the model in order to evade the precision electroweak constraints. We then explore the characteristic signatures to test the model in the current and future collider experiments. We find that the LHC has great potential to discover the new SU(2) gauge bosons and the possible new U(1) gauge boson to the multi-TeV mass scale. Other states such as the colored vector-like quark T and doubly-charged Higgs boson Phi^{++} may also provide interesting signals. At a linear collider, precision measurements on the triple gauge boson couplings could be sensitive to the new physics scale of a few TeV. We provide a comprehensive list of the linearized interactions and vertices for the littlest Higgs model in the appendices.Comment: 43 pages, 6 figures; v2: discussion clarified, typos corrected; v3: version to appear in PRD; v4: typos fixed in Feynman rule

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis

To determine whether MDR1 reversal by the addition of the P-glycoprotein (P-gp) inhibitor PSC-833 to standard induction chemotherapy would improve event-free survival (EFS), 419 untreated patients with acute myeloid leukemia (AML) aged 60 years and older were randomized to receive 2 induction cycles of daunorubicin and cytarabine with or without PSC-833. Patients in complete remission were then given 1 consolidation cycle without PSC-833. Neither complete response (CR) rate (54% versus 48%; P = .22), 5-year EFS (7% versus 8%; P = .53), disease-free survival (DFS; 13% versus 17%; P = .06) nor overall survival (OS; 10% in both arms; P = .52) were significantly improved in the PSC-833 arm. An integrated P-gp score (IPS) was determined based on P-gp function and P-gp expression in AML cells obtained prior to treatment. A higher IPS was associated with a significantly lower CR rate and worse EFS and OS. There was no significant interaction between IPS and treatment arm with respect to CR rate and survival, indicating also a lack of benefit of PSC-833 in P-gp-positive patients. The role of strategies aimed at inhibitory P-gp and other drug-resistance mechanisms continues to be defined in the treatment of patients with AML

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Task Division in Collaborative Simulations

In this paper we describe a study conducted to evaluate the effectiveness of task division on collaboration between pairs of users in a synchronous groupware simulation. The study involved measuring and analyzing over 50 performance criteria on 16 team pairs. Statistically significant results show task division increased team interaction and improved group performance in subsequent unrelated group activities when compared to a control version of the software. The simulation, CollabBillboard, was developed as part of Rensselaer Polytechnic Institute's technology enhanced collaborative classroom