Inclusive or exclusive? Investigating how retail technology can reduce old consumers’ barriers to shopping

This paper investigates older consumers in-store shopping experiences and the barriers that they face. The aim is to understand how new retail technologies (e.g., interactive in-store displays, self-service tills, robots etc.) can help seniors access satisfying, autonomous retail experiences, helping them to achieve a sense of inclusion in physical retail settings. Drawing upon the social inclusion/exclusion theory and information overload theory, the research employs a qualitative approach based on an inductive design, including face-to-face semi structured interviews with 36 consumers aged 75+. The findings highlight (i) old consumers have scarce interactions with in-store technologies (adding knowledge to motivations literature), (ii) the need to develop new technologies to support these consumers, and (iii) the extent to which these technologies are excluding rather than including old consumers (adding knowledge to the drivers of the field of exclusion). Results provide guidelines for retailers to enhance the sense of inclusion for old consumers through a better usage of new technologies

Gyrotropic impact upon negatively refracting surfaces

Surface wave propagation at the interface between different types of gyrotropic materials and an isotropic negatively refracting medium, in which the relative permittivity and relative permeability are, simultaneously, negative is investigated. A general approach is taken that embraces both gyroelectric and gyromagnetic materials, permitting the possibility of operating in either the low GHz, THz or the optical frequency regimes. The classical transverse Voigt configuration is adopted and a complete analysis of non-reciprocal surface wave dispersion is presented. The impact of the surface polariton modes upon the reflection of both plane waves and beams is discussed in terms of resonances and an example of the influence upon the Goos–Hänchen shift is given

Stable isotope values in modern bryozoan carbonate from New Zealand and implications for paleoenvironmental interpretation

Bryozoan carbonate contains useful geochemical evidence of temperate shelf paleoenvironments. Stable isotope values were determined for 103 modern marine bryozoan skeletons representing 30 species from New Zealand. δ18O values range from -1.4 to 2.8 VPDB, while δ13C range from -4.5 to 2.8 VPDB (values uncorrected for mineralogical variation). These values are distinct from those of both tropical marine skeletons and New Zealand Tertiary fossils. Most bryozoans secrete carbonate in or near isotopic equilibrium with sea water, except for Celleporina and Steginoporella. The complex and variable mineralogies of the bryozoans reported here make correction for mineralogical effects problematic. Nevertheless, mainly aragonitic forms display higher isotope values, as anticipated. Both temperature and salinity constrain δ18O and δ13C values, and vary with latitude and water depth. Ten samples from a single branch of Cinctipora elegans from the Otago shelf cover a narrow range, although the striking difference in carbon isotope values between the endozone and exozone probably reflects different mineralisation histories. Our stable isotope results from three different laboratories on a single population from a single location are encouragingly consistent. Monomineralic bryozoans, when carefully chosen to avoid species suspected of vital fractionation, have considerable potential as geochemical paleoenvironmental indicators, particularly in temperate marine environments where bryozoans are dominant sediment producers

Information scraps: how and why information eludes our personal information management tools

In this paper we describe information scraps -- a class of personal information whose content is scribbled on Post-it notes, scrawled on corners of random sheets of paper, buried inside the bodies of e-mail messages sent to ourselves, or typed haphazardly into text files. Information scraps hold our great ideas, sketches, notes, reminders, driving directions, and even our poetry. We define information scraps to be the body of personal information that is held outside of its natural or We have much still to learn about these loose forms of information capture. Why are they so often held outside of our traditional PIM locations and instead on Post-its or in text files? Why must we sometimes go around our traditional PIM applications to hold on to our scraps, such as by e-mailing ourselves? What are information scraps' role in the larger space of personal information management, and what do they uniquely offer that we find so appealing? If these unorganized bits truly indicate the failure of our PIM tools, how might we begin to build better tools? We have pursued these questions by undertaking a study of 27 knowledge workers. In our findings we describe information scraps from several angles: their content, their location, and the factors that lead to their use, which we identify as ease of capture, flexibility of content and organization, and avilability at the time of need. We also consider the personal emotive responses around scrap management. We present a set of design considerations that we have derived from the analysis of our study results. We present our work on an application platform, jourknow, to test some of these design and usability findings

RNA-Sequencing Reveals Direct Targets of Tumor Suppressor miR-203 in Human Mammary Epithelial Cells

Background: Breast cancer is the leading cause of cancer-related mortality in women worldwide. Since a significant portion of cases present with or progress to metastatic disease, furthering our understanding of metastasis is critical to develop better treatments. Epithelial cells maintain contact with the extracellular matrix (ECM) predominantly via integrin engagement, a process required for tissue integrity and barrier function. In non-transformed cells, loss of ECM adhesion promotes a specialized form of programmed cell death, anoikis. In order for efficient metastasis to occur, breast tumor cells must evade anoikis. miR-203, known to be down-regulated in several cancers, was found by our lab to be induced ten-fold 24 hours following detachment in breast epithelial cells, but not invasive triple negative breast cancer (TNBC) cells, suggesting that miR-203 may participate in promoting anoikis. Interestingly, more invasive breast cancer cell lines have been shown to express miR-203 at significantly lower levels than those of less invasive lines. Objectives: Since restoration of miR-203 expression ectopically is not feasible in a clinical setting, we sought to identify and characterize miR-203 target genes in order to provide a pharmaceutical platform for restoration of anoikis sensitivity in metastatic breast cancer. Methods: We performed traditional RNA-sequencing (RNA-Seq) coupled with immunoprecipitation of the RNA-induced silencing complex (RISC; Ago2 RIP-Seq) in MCF-10A, an immortalized, but non-transformed breast epithelial cell line, overexpressing precursor miR-203 or an empty vector control. MDA-MB-231, triple negative ductal carcinoma cells, were used as our invasive comparison cell line. Results: Here we show that miR-203 induction in detached MCF-10A cells is due to loss of integrin signaling. Our coupled RNA-Seq and Ago2 RIP-Seq approach revealed 72 potential candidates, 42 of which were predicted miR-203 targets based on the TargetScan algorithm. We subjected the candidates to stringent characterization and found 9 bona-fide miR-203 targets that promote cell death when inhibited. Among these, WDR69, PRKAB1, PRPS2, and HBEGF were significantly elevated in TNBC tumor samples, as determined by RNA-Seq analysis in The Cancer Genome Atlas (TCGA). Conclusion: Understanding the mechanisms by which cells evade anoikis during tumor dissemination is crucial to developing more effective therapies in breast cancer. miR-203, which is expressed at very low levels in more invasive breast cancers, is a positive regulator of anoikis that is upregulated in response to loss of contact with the ECM. Our combined RNA-sequencing screen revealed 42 direct miR-203 targets. Inhibition of 9 bona-fide targets promoted cell death, suggesting that they are negative regulators of anoikis. WDR69, PRKAB1, PRPS2, and HBEGF were all significantly elevated in TNBC tumor samples relative to less invasive samples, likely a consequence of low miR-203 expression. The identified genes represent potential pharmaceutical targets for novel breast cancer therapies

Biostratigraphy of Middle and Late Pennsylvanian (Desmoinesian-Virgilian) ammonoids

New stratigraphic ranges for genera of Desmoinesian-Virgilian ammonoids are presented, based on analysis of 40,000 specimens collected from over 70 ammonoid-bearing horizons that represent at least 40 successive stratigraphic levels in the North American midcontinent. These range revisions indicate that current generic-level ammonoid zonations are inadequate, especially for correlation of Pennsylvanian series and stage boundaries. Six high-confidence, largely generic-level first-occurrence zones are proposed for the Desmoinesian through Virgilian stages: Wellerites Zone, Eothalassoceras Zone, Pennoceras Zone, Preshumardites Zone, Pseudaktubites Zone, and Shumardites Zone. Fifteen zones of lesser confidence for correlation are also suggested. The Shumarditidae Plummer & Scott, 1937, is emended to include Preshumardites Plummer & Scott, 1937, Pseudaktubites gen. nov. (type species, Preshumardites stainbrooki Plummer & Scott, 1937), and Shumardites Smith, 1903. Early Permian (Sakmarian) species previously assigned to Preshumardites are reassigned to Andrianovia gen. nov. (type species ?Preshumardites sakmarae Ruzhencev, 1938). Aktubites Ruzhencev, 1955, Eoshumardites Popov, 1960, and Parashumardites Ruzhencev, 1939, previously included in the Shumarditidae, are assigned to the new family Parashumarditidae. Eovidrioceras inexpectans gen. nov., sp. nov. is included and is interpreted as the ancestor of the cyclobacean family Vidrioceratidae Plummer & Scott, 1937. The base of the revised Wellerites Zone, defined by the first occurrence of the nominate genus, approximates but does not coincide with the Atokan-Desmoinesian boundary. Recorrelation of the stratigraphic level of the Collinsville, Oklahoma, ammonoid locality from the "Seminole Formation" (basal Missourian) to the Holdenville Formation (upper Desmoinesian), based on lithostratigraphic evidence, effectively places the first occurrence of Eothalassoceras in the upper Desmoinesian. Because Wellerites apparently became extinct before the end of the Desmoinesian, the revised Eothalassoceras Zone is used to represent the upper Desmoinesian. The Middle-Upper Pennsylvanian boundary (Desmoinesian-Missourian boundary) can be recognized by the appearance of Pennoceras, which defines the base of the new Pennoceras Zone. The Pennoceras Zone is an excellent indicator of lower Missourian strata in the northern midcontinent, north-central Texas, the Marathon Uplift, and the Appalachian Basin. The new Preshumardites Zone occupies most of the upper part of the Missourian Stage. The appearance of the ancestral shumarditid Pseudaktubites, which defines the base of the new Pseudaktubites Zone, occurs one cycle below the Missourian-Virgilian boundary, which is currently recognized at the top of the South Bend Limestone Member in eastern Kansas. No recognizable biostratigraphic event coincides with the South Bend Member, thereby resulting in an uncorrelatable chronostratigraphic boundary. The largest changeover in ammonoid faunas takes place at the base of strata containing the upper part of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone). The base of the Pseudaktubites stainbrooki Subzone is stratigraphically near the original Missourian-Virgilian boundary. It is recommended that the stratigraphic level containing the base of the Pseudaktubites stainbrooki Subzone be adopted as the official base of the Virgilian Stage. Recognition of the upper subzone of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone) within the Colony Creek Shale Member in north-central Texas places the base of the Virgilian within the upper part of the Canyon Group and substantially below the current position at the Canyon-Cisco group boundary. Shumardites, a taxon previously used to mark the base of the Virgilian Stage, appears in early middle Virgilian strata; consequently, the revised Shumardites Zone represents the middle-upper Virgilian interval

Biostratigraphy of Middle and Late Pennsylvanian (Desmoinesian-Virgilian) ammonoids

New stratigraphic ranges for genera of Desmoinesian-Virgilian ammonoids are presented, based on analysis of 40,000 specimens collected from over 70 ammonoid-bearing horizons that represent at least 40 successive stratigraphic levels in the North American midcontinent. These range revisions indicate that current generic-level ammonoid zonations are inadequate, especially for correlation of Pennsylvanian series and stage boundaries. Six high-confidence, largely generic-level first-occurrence zones are proposed for the Desmoinesian through Virgilian stages: Wellerites Zone, Eothalassoceras Zone, Pennoceras Zone, Preshumardites Zone, Pseudaktubites Zone, and Shumardites Zone. Fifteen zones of lesser confidence for correlation are also suggested. The Shumarditidae Plummer & Scott, 1937, is emended to include Preshumardites Plummer & Scott, 1937, Pseudaktubites gen. nov. (type species, Preshumardites stainbrooki Plummer & Scott, 1937), and Shumardites Smith, 1903. Early Permian (Sakmarian) species previously assigned to Preshumardites are reassigned to Andrianovia gen. nov. (type species ?Preshumardites sakmarae Ruzhencev, 1938). Aktubites Ruzhencev, 1955, Eoshumardites Popov, 1960, and Parashumardites Ruzhencev, 1939, previously included in the Shumarditidae, are assigned to the new family Parashumarditidae. Eovidrioceras inexpectans gen. nov., sp. nov. is included and is interpreted as the ancestor of the cyclobacean family Vidrioceratidae Plummer & Scott, 1937. The base of the revised Wellerites Zone, defined by the first occurrence of the nominate genus, approximates but does not coincide with the Atokan-Desmoinesian boundary. Recorrelation of the stratigraphic level of the Collinsville, Oklahoma, ammonoid locality from the "Seminole Formation" (basal Missourian) to the Holdenville Formation (upper Desmoinesian), based on lithostratigraphic evidence, effectively places the first occurrence of Eothalassoceras in the upper Desmoinesian. Because Wellerites apparently became extinct before the end of the Desmoinesian, the revised Eothalassoceras Zone is used to represent the upper Desmoinesian. The Middle-Upper Pennsylvanian boundary (Desmoinesian-Missourian boundary) can be recognized by the appearance of Pennoceras, which defines the base of the new Pennoceras Zone. The Pennoceras Zone is an excellent indicator of lower Missourian strata in the northern midcontinent, north-central Texas, the Marathon Uplift, and the Appalachian Basin. The new Preshumardites Zone occupies most of the upper part of the Missourian Stage. The appearance of the ancestral shumarditid Pseudaktubites, which defines the base of the new Pseudaktubites Zone, occurs one cycle below the Missourian-Virgilian boundary, which is currently recognized at the top of the South Bend Limestone Member in eastern Kansas. No recognizable biostratigraphic event coincides with the South Bend Member, thereby resulting in an uncorrelatable chronostratigraphic boundary. The largest changeover in ammonoid faunas takes place at the base of strata containing the upper part of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone). The base of the Pseudaktubites stainbrooki Subzone is stratigraphically near the original Missourian-Virgilian boundary. It is recommended that the stratigraphic level containing the base of the Pseudaktubites stainbrooki Subzone be adopted as the official base of the Virgilian Stage. Recognition of the upper subzone of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone) within the Colony Creek Shale Member in north-central Texas places the base of the Virgilian within the upper part of the Canyon Group and substantially below the current position at the Canyon-Cisco group boundary. Shumardites, a taxon previously used to mark the base of the Virgilian Stage, appears in early middle Virgilian strata; consequently, the revised Shumardites Zone represents the middle-upper Virgilian interval

Shape-induced anisotropy in antidot arrays from self-assembled templates

Using self-assembly of polystyrene spheres, well-ordered templates have been prepared on glass and silicon substrates. Strong guiding of self-assembly is obtained on photolithographically structured silicon substrates. Magnetic antidot arrays with three-dimensional architecture have been prepared by electrodeposition in the pores of these templates. The shape anisotropy demonstrates a crucial impact on magnetization reversal processes