Morphology and neuromuscular properties of chelae of decapod crustacean species from temperate and tropical populations

...Both species of decapods showed no seasonal differences in chela muscle performance. Their ability to function over wide ranges of temperatures is undoubtly essential in their successful latitudinal distribution. The difference in the capacity of these two species to rapidly acclimate to cold temperatures is reflected in their natural habitats. C. sapidus lives in estuaries where large short term temperature fluctuations are common. M. mercenaria, a marine coastal subtidal dweller, lives where temperature fluctuations are smaller

BIO 460-01, Internship in Biology, Spring 2005

This syllabus was submitted to the Rhodes College Office of Academic Affairs by the course instructor.Internships are arranged through Sandi George Tracy in Career Services. The grade for this course is pass/fail and it does NOT count as upper level Biology credit toward the major requirements. However, it does count as hours toward the 112 required for graduation. 1. As per the College catalogue, you are expected to spend a minimum of 46 hours of work toward one hour of academic credit. For a three hour course, this averages a little over 9 hours per week. Therefore, it is suggested you spend about 8 hours per week on site at your internship leaving about one hour per week for your more academic related obligations. (Adjust the time proprotionally if you are one of the few taking more or fewer hours of internship credit.) When you turn in your journal and paper, it will be assumed you have met the time requirements unless you inform me otherwise. Some of you will have enrolled for fewer than three credit hours. In that case, check with me for time requirements. 2. You must keep a journal which details your activities and your impressions. Please make entries in a timely fashion -- ideally, just after you return from your internship. I will review the journal at the end of the semester. If it is handwritten and you don't have an electronic copy, it will be available for you to pick up at the beginning of next semester. 3. You must write a term paper on a topic of your choice. There are no set guidelines on the paper topic or length (although 10-15 pages is a typical range). However, you must carefully research and reference your topic. I would suggest you share some ideas with your internship sponsor(s) and seek advice on references to get you started. Topics in past years have included case studies; analyses of specific diseases, conditions or treatments; economical or philosophical analyses of health care, doctor-patient relationships, or insurance. You may wish to discuss your proposed topic with me around midterm. Please complete the paper and give one copy to your internship sponsor (if you have more than one, then give it to the most appropriate one) and one copy to me by 5:00 pm on the LAST DAY OF CLASSES for the current semester (you have all semester to work on this; you may turn it in as early as you like, but I will not approve extensions). Also, turn in your journal on the last day of classes. Your pass/fail grade in this course will be determined by me in consultation with your sponsor(s). Roughly equal weighting will be given to your written assignments [for the paper, about half on style (spelling, grammar, clarity, conciseness, organization) and half on content (accuracy, depth of understanding, level of analysis, use of references) and your participation on site. Please make every effort to be a curious, involved and helpful intern. If any problems or concerns should arise in your internship, please contact the Biology Dept. internship coordinator or Sandi George Tracy in Career Services as soon as possible

BIOL 460-01, Internship in Biology, Spring 2005

This syllabus was submitted to the Rhodes College Office of Academic Affairs by the instructor

FORM AND FUNCTION OF THE ASYMMETRIC CHELAE IN BLUE CRABS WITH NORMAL AND REVERSED HANDEDNESS

Volume: 168Start Page: 321End Page: 33

CHEM 485-01, Senior Seminar, Fall 2003

This syllabus was submitted to the Office of Academic Affairs by the course instructor.Senior Seminars are designed to further critical thinking skills through the exploration and discussion of primary research literature, and to provide an opportunity to improve oral and written communication skills

Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning

Summary: Meaningful auditory memories are formed in adults when acoustic information is delivered to the auditory cortex during heightened states of attention, vigilance, or alertness, as mediated by neuromodulatory circuits. Here, we identify that, in awake mice, acoustic stimulation triggers auditory thalamocortical projections to release adenosine, which prevents cortical plasticity (i.e., selective expansion of neural representation of behaviorally relevant acoustic stimuli) and perceptual learning (i.e., experience-dependent improvement in frequency discrimination ability). This sound-evoked adenosine release (SEAR) becomes reduced within seconds when acoustic stimuli are tightly paired with the activation of neuromodulatory (cholinergic or dopaminergic) circuits or periods of attentive wakefulness. If thalamic adenosine production is enhanced, then SEAR elevates further, the neuromodulatory circuits are unable to sufficiently reduce SEAR, and associative cortical plasticity and perceptual learning are blocked. This suggests that transient low-adenosine periods triggered by neuromodulatory circuits permit associative cortical plasticity and auditory perceptual learning in adults to occur

The NALCN channel regulates metastasis and nonmalignant cell dissemination.

Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289Funder: American Lebanese Syrian Associated Charities (ALSAC); doi: https://doi.org/10.13039/100012524Funder: U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics); doi: https://doi.org/10.13039/100011541Funder: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI); doi: https://doi.org/10.13039/100000054Funder: RCUK | MRC | Medical Research Foundation; doi: https://doi.org/10.13039/501100009187We identify the sodium leak channel non-selective protein (NALCN) as a key regulator of cancer metastasis and nonmalignant cell dissemination. Among 10,022 human cancers, NALCN loss-of-function mutations were enriched in gastric and colorectal cancers. Deletion of Nalcn from gastric, intestinal or pancreatic adenocarcinomas in mice did not alter tumor incidence, but markedly increased the number of circulating tumor cells (CTCs) and metastases. Treatment of these mice with gadolinium-a NALCN channel blocker-similarly increased CTCs and metastases. Deletion of Nalcn from mice that lacked oncogenic mutations and never developed cancer caused shedding of epithelial cells into the blood at levels equivalent to those seen in tumor-bearing animals. These cells trafficked to distant organs to form normal structures including lung epithelium, and kidney glomeruli and tubules. Thus, NALCN regulates cell shedding from solid tissues independent of cancer, divorcing this process from tumorigenesis and unmasking a potential new target for antimetastatic therapies