Correspondence between Mark Keller and Sheila Blume (1980-1990)

Correspondence between Mark Keller and Sheila Blume (1980-1990) related to the oral history project that resulted in an interview published in the journal Addiction: Conversation with Mark Keller, V. 80, issue 1, p 5-9 in 1985. Full audio tapes also available in the CAS Archives. From the Mark Keller Papers

Domestic violence, alcohol and substance abuse Violência doméstica, abuso de álcool e substâncias psicoativas

Domestic violence and substance abuse are common in primary care patients. Although these problems are associated with severe physical and psychological sequelae, they are often undiagnosed. This article provides an overview of the prevalence of these problems, the health-related consequences for adults, children and elderly, as well as the challenges for clinicians in screening, assessment and referral.<br>Violência doméstica e abuso de substâncias psicoativas são comuns em pacientes atendidos no sistema de saúde de baixa complexidade. Apesar de estes problemas acarretarem graves seqüelas físicas e psicológicas, eles freqüentemente não são diagnosticados. Este artigo oferece uma revisão ampla sobre a prevalência destes problemas e suas conseqüências para a saúde de adultos, crianças e idosos, bem como discute os desafios enfrentados por médicos clínicos para a sua detecção, avaliação e encaminhamento

HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease

Parkinson's disease is a common neurodegenerative disorder characterized by a profound motor disability that is traceable to the emergence of synchronous, rhythmic spiking in neurons of the external segment of the globus pallidus (GPe). The origins of this pathophysiology are poorly defined for the generation of pacemaking. After the induction of a parkinsonian state in mice, there was a progressive decline in autonomous GPe pacemaking, which normally serves to desynchronize activity. The loss was attributable to the downregulation of an ion channel that is essential in pacemaking, the hyperpolarization and cyclic nucleotide-gated (HCN) channel. Viral delivery of HCN2 subunits restored pacemaking and reduced burst spiking in GPe neurons. However, the motor disability induced by dopamine (DA) depletion was not reversed, suggesting that the loss of pacemaking was a consequence, rather than a cause, of key network pathophysiology, a conclusion that is consistent with the ability of L-type channel antagonists to attenuate silencing after DA depletion