40 research outputs found
Analytical results on quantum interference and magnetoconductance for strongly localized electrons in a magnetic field: Exact summation of forward-scattering paths
We study quantum interference effects on the transition strength for strongly
localized electrons hopping on 2D square and 3D cubic lattices in the presence
of a magnetic field B. These effects arise from the interference between phase
factors associated with different electron paths connecting two distinct sites.
For electrons confined on a square lattice, with and without disorder, we
obtain closed-form expressions for the tunneling probability, which determines
the conductivity, between two arbitrary sites by exactly summing the
corresponding phase factors of all forward-scattering paths connecting them. An
analytic field-dependent expression, valid in any dimension, for the
magnetoconductance (MC) is derived. A positive MC is clearly observed when
turning on the magnetic field. In 2D, when the strength of B reaches a certain
value, which is inversely proportional to twice the hopping length, the MC is
increased by a factor of two compared to that at zero field. We also
investigate transport on the much less-studied and experimentally important 3D
cubic lattice case, where it is shown how the interference patterns and the
small-field behavior of the MC vary according to the orientation of B. The
effect on the low-flux MC due to the randomness of the angles between the
hopping direction and the orientation of B is also examined analytically.Comment: 24 pages, RevTeX, 8 figures include
Manifestation of triplet superconductivity in superconductor-ferromagnet structures
We study proximity effects in a multilayered superconductor/ferromagnet (S/F)
structure with arbitrary relative directions of the magnetization . If
the magnetizations of different layers are collinear the superconducting
condensate function induced in the F layers has only a singlet component and a
triplet one with a zero projection of the total magnetic moment of the Cooper
pairs on the direction. In this case the condensate penetrates the F
layers over a short length determined by the exchange energy . If
the magnetizations are not collinear the triplet component has, in
addition to the zero projection, the projections . The latter component
is even in the momentum, odd in the Matsubara frequency and penetrates the F
layers over a long distance that increases with decreasing temperature and does
not depend on (spin-orbit interaction limits this length). If the thickness
of the F layers is much larger than , the Josephson coupling between
neighboring S layers is provided only by the triplet component, so that a new
type of superconductivity arises in the transverse direction of the structure.
The Josephson critical current is positive (negative) for the case of a
positive (negative) chirality of the vector . We demonstrate that this
type of the triplet condensate can be detected also by measuring the density of
states in F/S/F structures.Comment: 14 pages; 9 figures. Final version, to be published in Phys. Rev.
Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors
Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the synaptic function of A2AR in age-related conditions. We report, for the first time, a significant overexpression of A2AR in hippocampal neurons of aged humans, which is aggravated in AD patients. A similar profile of A2AR overexpression in rats was sufficient to drive age-like memory impairments in young animals and to uncover a hippocampal LTD-to-LTP shift. This was accompanied by increased NMDA receptor gating, dependent on mGluR5 and linked to enhanced Ca(2+) influx. We confirmed the same plasticity shift in memory-impaired aged rats and APP/PS1 mice modeling AD, which was rescued upon A2AR blockade. This A2AR/mGluR5/NMDAR interaction might prove a suitable alternative for regulating aberrant mGluR5/NMDAR signaling in AD without disrupting their constitutive activity
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Empowerment/sexism: Figuring female sexual agency in contemporary advertising
This paper argues that there has been a significant shift in advertising representations of women in recent years, such that rather than being presented as passive objects of the male gaze, young women in adverts are now frequently depicted as active, independent and sexually powerful. This analysis examines contemporary constructions of female sexual agency in advertisements examining three recognizable ‘figures’: the young, heterosexually desiring ‘midriff’, the vengeful woman set on punishing her partner or ex partner for his transgressions, and the ‘hot lesbian’, almost always entwined with her beautiful Other or double. Using recent examples of adverts the paper asks how this apparent ‘agency’ and ‘empowerment’ should be understood.
Drawing on accounts of the incorporation or recuperation of feminist ideas in advertising the paper takes a critical approach to these representations, examining their exclusions, their constructions of gender relations and heteronormativity, and the way power is figured within them. A feminist poststructuralist approach is used to interrogate the way in which ‘sexual agency’ becomes a form of regulation in these adverts, that requires the re-moulding of feminine subjectivity to fit the current postfeminist, neoliberal moment in which young women should not only be beautiful but sexy, sexually knowledgeable/practised and always ‘up for it’.
The paper makes an original contribution to debates about representations of gender in advertising, to poststructuralist analyses about the contemporary operation of power, and to writing about female ‘sexual agency’ by suggesting that ‘voice’ or ‘agency’ may not be the solution to the ‘missing discourse of female desire' but may in fact be a technology of discipline and regulation
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury
AIM: Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) action ameliorated ischemia/reperfusion (I/R)-induced AKI in rats. Now we tested the hypothesis that enhancement of epoxyeicosatrienoic acid (EET) actions may counteract the detrimental effects of 20-HETE and prevent the initiation of AKI. METHODS: Male Lewis rats underwent right nephrectomy and ischemia was induced by 45 min clamping of the left renal pedicle followed by up to 48 h of reperfusion. Circulating CYP-eicosanoid profiles were compared in patients who underwent cardiac surgery with (n = 21) and without (n = 38) developing postoperative AKI. RESULTS: Ischemia induced an about eightfold increase of renal 20-HETE levels, whereas free EETs were not accumulated. To compensate for this imbalance, a synthetic 14,15-EET analogue was administered by intrarenal infusion before ischemia. The EET analogue improved renal reoxygenation as monitored by in vivo parametric MRI during the initial 2 h reperfusion phase. The EET analogue improved PI3K- as well as mTORC2-dependent rephosphorylation of Akt, induced inactivation of GSK-3β, reduced the development of tubular apoptosis and attenuated inflammatory cell infiltration. The EET analogue also significantly alleviated the I/R-induced drop in creatinine clearance. Patients developing postoperative AKI featured increased preoperative 20-HETE and 8,9-EET levels. CONCLUSIONS: Pharmacological interventions targeting the CYP-eicosanoid pathway could offer promising new options for AKI prevention. Individual differences in CYP-eicosanoid formation may contribute to the risk of developing AKI in clinical settings