Long-term potentiation and long-term depression: a clinical perspective

Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system. Work in a number of brain regions, from the spinal cord to the cerebral cortex, and in many animal species, ranging from invertebrates to humans, has demonstrated a reliable capacity for chemical synapses to undergo lasting changes in efficacy in response to a variety of induction protocols. In addition to their physiological relevance, long-term potentiation and depression may have important clinical applications. A growing insight into the molecular mechanisms underlying these processes, and technological advances in non-invasive manipulation of brain activity, now puts us at the threshold of harnessing long-term potentiation and depression and other forms of synaptic, cellular and circuit plasticity to manipulate synaptic strength in the human nervous system. Drugs may be used to erase or treat pathological synaptic states and non-invasive stimulation devices may be used to artificially induce synaptic plasticity to ameliorate conditions arising from disrupted synaptic drive. These approaches hold promise for the treatment of a variety of neurological conditions, including neuropathic pain, epilepsy, depression, amblyopia, tinnitus and stroke

Farming Within Limits

Global agricultural production is alarmingly unsustainable. Manipulating living beings, their genetics, and entire ecosystems to produce food has always been a technological feat. Advancements in farming technology have made it possible to surpass critical thresholds of planetary sustainability. Technological change in agriculture generates tension between those who benefit and those who bear the costs. Agriculture produces more than enough to feed the world’s human population, but the global economy allocates food inequitably among people and redirects food to industrial feedlots, biofuel refineries, and the waste stream. Technical solutions alone cannot fix the underlying socioeconomic systems that produce unjust and unsustainable food systems. Here we offer a starting point to guide the assessment of agricultural technology for both sustainability and justice, starting with their relationship to the logic of growth and domination that got us here. How can technology serve system change? And how can farming transform the unjust systems it literally feeds

Non-Market Food Practices Do Things Markets Cannot: Why Vermonters Produce and Distribute Food That\u27s Not For Sale

Researchers tend to portray food self-provisioning in high-income societies as a coping mechanism for the poor or a hobby for the well-off. They describe food charity as a regrettable band-aid. Vegetable gardens and neighborly sharing are considered remnants of precapitalist tradition. These are non-market food practices: producing food that is not for sale and distributing food in ways other than selling it. Recent scholarship challenges those standard understandings by showing (i) that non-market food practices remain prevalent in high-income countries, (ii) that people in diverse social groups engage in these practices, and (iii) that they articulate diverse reasons for doing so. In this dissertation, I investigate the persistent pervasiveness of non-market food practices in Vermont. To go beyond explanations that rely on individual motivation, I examine the roles these practices play in society. First, I investigate the prevalence of non-market food practices. Several surveys with large, representative samples reveal that more than half of Vermont households grow, hunt, fish, or gather some of their own food. Respondents estimate that they acquire 14% of the food they consume through non-market means, on average. For reference, commercial local food makes up about the same portion of total consumption. Then, drawing on the words of 94 non-market food practitioners I interviewed, I demonstrate that these practices serve functions that markets cannot. Interviewees attested that non-market distribution is special because it feeds the hungry, strengthens relationships, builds resilience, puts edible-but-unsellable food to use, and aligns with a desired future in which food is not for sale. Hunters, fishers, foragers, scavengers, and homesteaders said that these activities contribute to their long-run food security as a skills-based safety net. Self-provisioning allows them to eat from the landscape despite disruptions to their ability to access market food such as job loss, supply chain problems, or a global pandemic. Additional evidence from vegetable growers suggests that non-market settings liberate production from financial discipline, making space for work that is meaningful, playful, educational, and therapeutic. Non-market food practices mend holes in the social fabric torn by the commodification of everyday life. Finally, I synthesize scholarly critiques of markets as institutions for organizing the production and distribution of food. Markets send food toward money rather than hunger. Producing for market compels farmers to prioritize financial viability over other values such as stewardship. Historically, people rarely if ever sell each other food until external authorities coerce them to do so through taxation, indebtedness, cutting off access to the means of subsistence, or extinguishing non-market institutions. Today, more humans than ever suffer from chronic undernourishment even as the scale of commercial agriculture pushes environmental pressures past critical thresholds of planetary sustainability. This research substantiates that alternatives to markets exist and have the potential to address their shortcomings

Serial subtraction by sevens significantly alters limb knee adduction during lateral step-down when compared to the Stroop color-word test

"Dual tasking pairs movement and cognitive tasks to simulate real-world movement conditions. Dual tasking can lead to increased injury risk while performing dynamic lower limb movements. Bilateral asymmetry in neuromuscular control is suggested to play a role in the risk for lower limb injuries. Lower limb dominance influences motor control."--Introduction

A 2022 Assessment of Food Security and Health Outcomes during the COVID-19 Pandemic

We conducted a Northern New England survey to understand the impacts of the COVID-19 pandemic on food security, food access, home food production, health behaviors, and health outcomes. The surveys were conducted in the spring of 2022 (April-May) with a total of 1,013 adults (598 in Maine and 415 in Vermont) responding to the survey. Key findings include:1. The prevalence of food insecurity remains similarly high to early points in the pandemic, likely driven by inflation and food prices, and long-term impacts from the pandemic. 2. The majority (62%) indicated the recent rise in food prices affected their food purchasing, this was significantly higher (90%) for food insecure respondents. 3. 1/3 of respondents utilized food assistance programs in the last 12 months. They reported difficulty traveling to food program offices to apply or recertify as a key challenge. 4. 2/3 of respondents engaged in some kind of home food production (HFP) and half of those did HFP activities for the first time or did existing HFP activities more in the last 12 months. 5. Nearly 1/3 reported weight gain during the COVID-19 pandemic. Food insecure respondents were significantly more likely to report weight gain. 6. Nearly 40% of food insecure respondents ate fewer fruits and vegetables and certain animal products in the last 12 months. These changes are significantly higher than for food secure respondents. 7. Half of the respondents faced a health care challenge in the last 12 months, with canceled appointments and trouble finding a timely appointment being the most commonly reported challenges. 8. More than 50% of respondents indicated anxiety and/or depression, with 17% of those with a diagnosis newly diagnosed in the last 12 months. 9. Compared to food secure respondents, food insecure respondents were significantly more likely to face a variety of health challenges in the last 12 months, including difficulty accessing healthcare, being diagnosed with anxiety and depression, stopping and skipping medications due to cost, and using habit-forming substances

Home Food Production and Food Security Since the COVID-19 Pandemic

We conducted a Northern New England survey to understand the initial and continued impacts of the COVID-19 pandemic on food security, food access, and home food production (HFP) (i.e. gardening, fishing, harvesting shellfish, foraging, hunting, trapping, raising animals for meat, dairy, or eggs, and food preservation such as canning, drying or freezing). The surveys were conducted in the Spring and Summer of 2021 (March – June). The survey was conducted in Maine (n = 562) and Vermont (n = 426). The cohort of respondents was representative of racial and ethnic identities of Vermont and Maine state populations. The data presented in this research brief were weighted to be representative of income in both states. Here, we summarize our findings related to changes in food security, food sourcing, and HFP before and since the COVID-19 pandemic. When data are referred to as “significant” it indicates a statistical significance at p\u3c 0.05

Change in Food Security and Health Outcomes Since the COVID-19 Pandemic in Northern New England

We conducted a Northern New England survey in March-June of 2021 to understand the initial and continued impacts of the COVID-19 pandemic on food security, health behaviors, and health outcomes. A total of 988 adults (562 in Maine and 426 in Vermont) responded regarding food access and availability, health behaviors such as diet composition and exercise, and use of habit-forming substances (e.g. alcohol, tobacco, etc.) before and in the year following the onset of the COVID-19 pandemic. Key findings include: 1. 39.1% of Maine and 43.2% of Vermont respondents indicated weight gain since the start of the COVID-19 pandemic. 2. Individuals with food insecurity were significantly less likely to consume fruits and vegetables and engage in physical activity than those who report being food secure. 3. Nearly half of respondents indicated anxiety or depression during the COVID-19 pandemic. 4. Those with persistent food insecurity (i.e. food insecure before and during the COVID-19 pandemic) were 8.8 times more likely to experience higher levels of stress, 2.6 times more likely to experience anxiety and be diagnosed with diabetes type 2 and hypertension during the COVID-19 pandemic. 5. Individuals who identify as LGBTQ+ were more likely to be food insecure, 4 times more likely to report anxiety or depression, and also experienced higher levels of stress than individuals who did not identify as LGBTQ+ during the COVID-19 pandemic. 6. Individuals with food insecurity were up to 7 times more likely to skip or stop their medication for anxiety, depression, and/or hypertension, as compared to food secure respondents. 7. Individuals reporting the use of substances prior to the onset of the pandemic (e.g., tobacco, alcohol, and drugs) were more likely to have increased their use of additional habit-forming substances during the COVID-19 pandemic. Substance use was also associated with a higher prevalence of stress

Evolution of Anthropometric and Physical Performance Characteristics of International Male Cricketers from 2014 to 2020 in a World Cup Winning Nation

The aim of the study was to firstly, present a comprehensive physical profile of international cricketers in a World Cup winning cricket nation. Secondly, to describe changes in physical profiles across seven years. Fifty-two senior international cricketers’ physical profiles were retrospectively analysed across seven years. Using linear mixed-modelling, changes in stature, body mass, sum-of-8 skinfolds, sprinting time (10 and 40 m), run-2 time, counter movement jump (CMJ), push and pull strength capacity and the Yo-Yo intermittent recovery test level-1 (Yo-Yo-IR1) were analysed during a seven year period. There were no significant changes in body mass (p = 0.63) or stature (p = 0.99) during this time. However, there was a significant (p < 0.001) mean decrease of ∼ 14 mm in the sum-of-8 skinfolds. Distance covered in the Yo-Yo-IR1 also showed a significant (p = 0.002) effect of years, with a mean increase of 459 m in 2017 when compared to 2014. A significantly (p = 0.01) more balanced push-to-pull strength capacity ratio was also evident across years as a result of a significant (p < 0.001) increase in pull strength capacity. Significant (p < 0.05) fluctuations in CMJ, sprint and run-2 time were seen, with no obvious trends. International cricketers within our study have gone through a notable physical transformation that has likely resulted in an increase in lean mass and aerobic capacity. The change across time to a more balanced push-to-pull strength capacity may be beneficial for injury prevention

A study of time dependence during serial needle ice events

Soil surface temperature, net radiation and soil heave data during a series of eleven consecutive needle ice growth-melt cycles at Vancouver, Canada, were studied using computer-graphic techniques. A method of analyzing the morphologic evolution of a needle growth using surface temperature and soil heave data is presented. Lastly, an atmospheric-geomorphic correlation matrix derived partially from the analysis of surface temperature-heave data is used to highlight the importance of afternoon evaporation in determining the course of an individual needle ice event within an event series. Bodentemperatur, Strahlungsbilanz und Bodenbewegungsdaten aus Vancouver, Kanada, werden für eine Serie von elf aufeinanderfolgenden Wachstums- und Schmelzzyklen von Eisnadeln graphisch wiedergegeben. Eine Methode zur Analyse der morphologischen Entwicklung des Nadelwachstums mit Hilfe von Bodentemperaturen und Bodenbewegungsdaten wird beschrieben. Schießlich wird eine Korrelationsmatrize zwischen atmosphärischen und geomorphologischen Daten teilweise aus den Daten der Bodentemperatur und Bodenbewegung abgeleitet und dazu benützt, die Bedeutung der Verdunstung am Nachmittag für den Verlauf der Nadelbildung innerhalb der beschriebenen Serie zu demonstrieren.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41660/1/703_2005_Article_BF02250898.pd