CD 615 XL Discipleship Development in the Family

A study of the relationship of the church to the home in the joint enterprise of strengthening the family, nurturing children and bringing them to mature Christian discipleship. Special attention is given to the contemporary threats to family life and the emerging needs of the family.https://place.asburyseminary.edu/syllabi/3310/thumbnail.jp

Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia.

BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis/objectivesPlatelet dysfunction in horses with this second thrombasthenia results from a secretory defect.AnimalsTwo affected and 6 clinically normal horses.MethodsEx vivo study. Washed platelets were examined for (1) expression of the αIIb-β3 integrin; (2) fibrinogen binding capacity in response to ADP and thrombin; (3) secretion of dense and α-granules; (4) activation of the mammalian target of rapamycin (mTOR)-protein kinase B (AKT) signaling pathway; and (5) cellular distribution of phosphatidylinositol-4-phosphate-3-kinase, class 2B (PIK3C2B) and SH2 containing inositol-5'-phosphatase 1 (SHIP1).ResultsPlatelets from affected horses expressed normal amounts of αIIb-β3 integrin and bound fibrinogen normally in response to ADP, but bound 80% less fibrinogen in response to thrombin. α-granules only released 50% as much Factor V as control platelets, but dense granules released their contents normally. Protein kinase B (AKT) phosphorylation was reduced after thrombin activation, but mTOR Complex 2 (mTORC2) and phosphoinositide-dependent kinase 1 (PDK1) signaling were normal. SH2-containing inositol-5'-phosphatase 1 (SHIP1) did not localize to the cytoskeleton of affected platelets and was decreased overall consistent with reduced AKT phosphorylation.Conclusions and clinical significanceDefects in fibrinogen binding, granule secretion, and signal transduction are unique to this thrombasthenia, which we designate as atypical equine thrombasthenia

YM 665 Youth Culture and Trends

Class Texts 1) Web-based Publications: Chapman R. Clark, “Entering Their World: A Qualitative Look at the Changing Face of Contemporary Adolescence,” Journal of Youth Ministry (Fall 2002) available on-line (3/13/2006) at http://ayme.gospelcom.net/jym_article.php?article_id=21 Read also the five part seminar on Qualitative Research courtesy Don Ratcliff (3/14/2006) at http://don.ratcliffs.net/qual/ (apx. 25 pages). 2) Patricia Hersch, A Tribe Apart: A Journey Into the Heart of American Adolescence (New York: Ballentine Books Readers Companion, 1999), 379 pages; and Christian Smith, Soul Searching: The Religious and Spiritual Lives of American Teenagers (London: Oxford Press, 2005) 271 pages, appendices optional. NOTE: Hersch and Smith are the primary texts but please read Thomas Hine, The Rise and Fall of the American Teenager (New York: Avon Books, 1999; 315 pages) if you have read either Hersch or Smith for a different class. Regardless bring your copies of Hersch and Smith to class (we will discuss both texts at some point during class). 3) Pete Ward, God at the Mall: Youth Ministry that Meets Kids Where They are At (Peabody, MA: Hendrickson, 1999), 160 pages. 4) David White, Practicing Discernment with Youth (Cleveland: The Pilgram Press, 2005), 209 pages. 5) For an audio resources that supports the class, see audio interviews with Christian Smith and special journals like Youth Culture & the Church with Mardi Keyes & Pastor Mark DeVries from the Mars Hill Audio Journal: www.marshillaudio.orghttps://place.asburyseminary.edu/syllabi/1378/thumbnail.jp

YM 665 Youth Culture and Trends

Course Description: This course explores the issues facing youth today including sex, drugs/alcohol, media, music, family pressures, and modern philosophies. Students will examine theories of adolescent development, observe teenagers in secular and church settings, and prepare to minister to youth as they struggle with the issues of their culture.https://place.asburyseminary.edu/syllabi/3432/thumbnail.jp

YM 665 Youth Culture and Trends

Class Texts 1) Web-based Publications: Chapman R. Clark, “Entering Their World: A Qualitative Look at the Changing Face of Contemporary Adolescence,” Journal of Youth Ministry (Fall 2002) available on-line (6/9/2004) at http://ayme.gospelcom.net/jym_article.php?article_id=21 Read also the five part seminar on Qualitative Research courtesy Don Ratcliff (6/09/2004)at http://www.vanguard.edu/faculty/dratcliff/qual/ (apx. 25 pages). Also read Dean G. Blevins, “The Means of Grace and Christian Religious Education: Formation, Discernment, Transformation” 15 pages, online http://homepages.trevecca.edu/faculty/dblevins/Writings/Means%20Book%20Chapter %204.htm. 2) Patricia Hersch, A Tribe Apart: A Journey Into the Heart of American Adolescence (New York: Ballentine Books Readers Companion, 1999), 379 pages; OR Barbara Schneider & David Stevenson, The Ambitious Generation: America\u27s Teenagers, Motivated but Directionless (New Haven: Yale University Press, 1999), 276 pages. NOTE: Hersch is the primary text but please read Schneider & Stevenson if you have read Hersch for a different class for your book report. Regardless bring your copy of Hersch to class (we will discuss both texts at some point during class). 3) Pete Ward, God at the Mall: Youth Ministry that Meets Kids Where They are At (Peabody, MA: Hendrickson, 1999), 160 pages. 4) Michael Warren, Youth, Gospel, Liberation, 3rd edition (Chicago: ACTA Publications, 2000), 185 pages.https://place.asburyseminary.edu/syllabi/3842/thumbnail.jp