Slowly co-fluctuating gene expression patterns are heritable and associated with stress resistance and improved productivity in CHO cell line development

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Jean-Michel Leniaud [dir.], Le budget des cultes

Cet ouvrage de grand format (21x29,7), préfacé par Jean-Marie Mayeur, se compose de deux parties distinctes. La première (p. 9-105) est consacrée à la publication des actes d’une journée d’étude sur le budget des cultes qui s’est tenue le 30 janvier 2006 ; la seconde (p. 107-229) est une réédition scannée du précieux ouvrage éponyme de Charles-Marie Jourdain (1817-1886), qui fut publié en 1859 sous le titre Le budget des cultes en France, depuis le Concordat de 1801 jusqu’à nos jours (Paris, ..

(How) is formulaic language universal? Insights from Korean, German and English

The existence of common expressions, also referred to as formulaic language or phraseological units, has been evidenced in a very large number of languages. However, the extent to which languages feature such formulaic material, how formulaicity may be understood across typologically different languages and whether indeed there is a concept of formulaic language that applies across languages, are questions that have been less commonly discussed. Using a novel data set consisting of topically matched corpora in three typologically different languages (Korean, German and English), this study proposes an empirically founded universal concept for formulaic language and discusses what the shape of this concept suggests for the theoretical understanding of formulaic language going forward. In particular, it is argued that the nexus of the concept of formulaic language cannot be fixed at any particular structural level (such as the phrase or the level of polylexicality) and incorporates elements specified at varying levels of abstraction (or schematicity). This means that a cross-linguistic concept of formulaic language fits in well with a constructionist view of linguistic structure

Considering Culture in Autism Screening: Lessons Learned by the MA Act Early Team

Non-English and non-Caucasian children are diagnosed with autism spectrum disorders (ASD) and other developmental disorders at later ages, and with lower prevalence than their counterparts. The Massachusetts Act Early state team sought to address this gap so that at-risk families from diverse backgrounds receive more effective autism screening. Presented at the Association of University Centers on Disability 2012 Conference

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the revised Reinforcement Sensitivity Theory (rRST) of personality with respect to two major factors: behavioral inhibition system (BIS), fight/flight/freeze system (FFFS). Higher BIS and FFFS scores were negatively correlated with N1/P2 slopes at central sites (C3, Cz, C4). Conditional process analysis revealed that the BIS was a mediator of the association between the N1/P2 slope and the FFFS scores. An analysis of covariance showed that lower BIS scorers exhibited larger N1/P2 amplitudes across all tone intensities while watching negative, positive and neutral pictures. Additionally, lower FFFS scorers compared to higher FFFS scorers disclosed larger N1/P2 amplitudes to the highest tone intensities and these differences were even more pronounced while watching positive emotional pictures. Findings were explained assuming the operation of two different, but related processes: transmarginal inhibition for the BIS; the attention/emotional gating mechanism regulating cortical sensory input for the FFFS trait. These findings appear consistent with predictions derived from the rRST, which traced fear and anxiety to separate but interacting neurobehavioural systems

In-vehicle Drowsy Driving Detection and Alerting

DTNH2211D00237/0014Drowsy driving is a common phenomenon that increases the risk for fatal and injurious crashes. Technological innovations in the form of driver monitoring and notification systems may offer potential to reduce crashes due to drowsy driving. These systems monitor the driver\u2019s drowsy driving state and issue alerts when the driver is classified by the system as drowsy. Research shows that driver notification can be effective in improving performance over relatively short drives. However, the efficacy of such systems for improving performance and changing drowsy driver decision making over longer drives is unknown. The goal of this project was to evaluate the efficacy of two notifications, a lane departure warning (LDW) and a drowsiness notification with LDW (DN/LDW). The notification conditions were compared against a no-notification baseline during 4-hour overnight drives in a high-fidelity driving simulator with an incentive method designed to replicate the motivational tradeoffs common to drowsy driving, i.e., the desire to reach a destination versus one\u2019s own safety while driving drowsy. The combined DN/LDW, but not the LDW, was effective in reducing the frequency of lane departures and also in reducing the percentage of eyelid closure (PERCLOS) prior to lane departure events compared to baseline. There was no difference between the notification conditions and baseline with respect to the frequency or timing of breaks to rest, suggesting that although notifications improved driving performance, they did not alter decision making. These results suggest that notifications may aid drowsy drivers, but in-vehicle alerts may not be effective in changing the way drowsy drivers make decisions about whether and when to stop to rest

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIba subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane € Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb-IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors

3e colloque Montalembert

Organisé par l'Istituto Luigi Sturzo, en partenariat avec le Centre culturel Saint-Louis-de-France, un troisième colloque célèbrera le bicentenaire de la naissance de Charles de Montalembert. Il se tiendra à Rome les 2 et 3 décembre 2010 sous le titre Montalembert pensatore europeo. Programme : montalembert

Colloque sur laïcités et Islam, 13-14 janvier 2012

L'Université du Maine et le Centre de Recherches Historiques de l'Ouest (CERHIO) organisent, sous la direction d'Anaïs-Trissa KHATCHADOURIAN, Augustin JOMIER et Amin ELIAS,  un colloque intitulé : "Laïcités en sociétés majoritairement musulmanes et musulmans en contextes laïcs : Débats, expériences et confrontations (XIXe - XXe siècle)" Il se tiendra les 13 et 14 janvier 2012 à l'Université du Maine, Le Mans, salle de conférence du bâtiment Etn@. Contacts : [email protected] Program..

Une biographie du cardinal Suhard

Les Editions du Cerf viennent de sortir une biographie de l'homme qui dirigea le diocèse de Paris aux heures difficiles de l'Occupation et de l'après Seconde guerre mondiale : J.-P. Guérend, Cardinal Emmanuel Suhard, archevêque de Paris (1940-1949), Paris, octobre 2011, 384 p., 27 euros, préface d'Emile Poulat. Le Cardinal Suhard a laissé le souvenir d'une personnalité hors du commun, alliant un classicisme doctrinal à toute épreuve et une audace pastorale sans précédent. De cet homme de cara..