Optimal binning of X-ray spectra and response matrix design

A theoretical framework is developed to estimate the optimal binning of X-ray spectra. We derived expressions for the optimal bin size for model spectra as well as for observed data using different levels of sophistication. It is shown that by taking into account both the number of photons in a given spectral model bin and their average energy over the bin size, the number of model energy bins and the size of the response matrix can be reduced by a factor of $10-100$. The response matrix should then contain the response at the bin centre as well as its derivative with respect to the incoming photon energy. We provide practical guidelines for how to construct optimal energy grids as well as how to structure the response matrix. A few examples are presented to illustrate the present methods.Comment: 16 pages, 7 figures, accepted for publication in Astronomy and Astrophysic

Thrombocytosis: Diagnostic Evaluation, Thrombotic Risk Stratification, and Risk-Based Management Strategies

Thrombocytosis is a commonly encountered clinical scenario, with a large proportion of cases discovered incidentally. The differential diagnosis for thrombocytosis is broad and the diagnostic process can be challenging. Thrombocytosis can be spurious, attributed to a reactive process or due to clonal disorder. This distinction is important as it carries implications for evaluation, prognosis, and treatment. Clonal thrombocytosis associated with the myeloproliferative neoplasms, especially essential thrombocythemia and polycythemia vera, carries a unique prognostic profile, with a markedly increased risk of thrombosis. This risk is the driving factor behind treatment strategies in these disorders. Clinical trials utilizing targeted therapies in thrombocytosis are ongoing with new therapeutic targets waiting to be explored. This paper will outline the mechanisms underlying thrombocytosis, the diagnostic evaluation of thrombocytosis, complications of thrombocytosis with a special focus on thrombotic risk as well as treatment options for clonal processes leading to thrombocytosis, including essential thrombocythemia and polycythemia vera

The mass and energy budget of Cassiopeia A

Further analysis of X-ray spectroscopy results recently obtained from the MOS CCD cameras on-board XMM-Newton provides a detailed description of the hot and cool X-ray emitting plasma in Cas A. Measurement of the Doppler broadening of the X-ray lines is consistent with the expected ion velocities, ~1500 km/s along the line of sight, in the post shock plasma. Assuming a constant total pressure throughout the remnant we estimate the total remnant mass as 10 Msun and the total thermal energy as 7E43 J. We derive the differential mass distribution as a function of ionisation age for both X-ray emitting components. This distribution is consistent with a hot component dominated by swept up mass heated by the primary shock and a cool component which are ablated clumpy ejecta material which were and are still being heated by interaction with the preheated swept up material. We calculate a balanced mass and energy budget for the supernova explosion giving 1E44 J in ejected mass; approximately 0.4 Msun of the ejecta were diffuse with an initial rms velocity of 15000 km/s while the remaining ~1.8 Msun were clumpy with an initial rms velocity of ~2400 km/s. Using the Doppler velocity measurements of the X-ray spectral lines we can project the mass into spherical coordinates about the remnant. This provides quantitative evidence for mass and energy beaming in the supernova explosion. The mass and energy occupy less than 4.5 sr (<40 % of the available solid angle) around the remnant and 64 % of the mass occurs in two jets within 45 degrees of a jet axis. We calculate a swept up mass of 7.9 Msun in the emitting plasma and estimate that the total mass lost from the progenitor prior to the explosion could be as high as ~20 Msun.Comment: 8 pages, 7 figures, submitted to Astronomy & Astrophysic

High- and low energy nonthermal X-ray emission from the cluster of galaxies A 2199

We report the detection of both soft and hard excess X-ray emission in the cluster of galaxies A 2199, based upon spatially resolved spectroscopy with data from the BeppoSAX, EUVE and ROSAT missions. The excess emission is visible at radii larger than 300 kpc and increases in strength relative to the isothermal component. The total 0.1-100 keV luminosity of this component is 15 % of the cluster luminosity, but it dominates the cluster luminosity at high and low energies. We argue that the most plausible interpretation of the excess emission is an inverse Compton interaction between the cosmic microwave background and relativistic electrons in the cluster. The observed spatial distribution of the non-thermal component implies that there is a large halo of cosmic ray electrons between 0.5-1.5 Mpc surrounding the cluster core. The prominent existence of this component has cosmological implications, as it is significantly changing our picture of a clusters's particle acceleration history, dynamics between the thermal and relativistic media, and total mass budgets.Comment: Accepted for publication in Astrophysical Journal, Letter

“Malignant” Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies

Purpose. Perivascular epithelioid cell tumors (PEComas) are a rare collection of tumors characterized by a myomelanocytic phenotype, and PEComas occurring in “nonclassic” anatomic distributions are known as perivascular epithelioid cell tumor not otherwise specified (PEComa-NOS). This review aims to compile and analyze cases of PEComa-NOS in an effort to better define their natural history. Design. We evaluated all 234 cases of PEComa-NOS reported in the English literature, extracting information regarding diagnostic features, treatment approaches, and outcomes. Multivariate analysis of a number of variables evaluable on pathologic review was performed to refine preexisting risk stratification criteria. Outcomes for patients receiving nonsurgical treatment are also reported. Results. Primary tumor size ≥5 cm (P = 0.02) and a high (1/50 HPF) mitotic rate (P < 0.0001) were the only factors significantly associated with recurrence following surgical resection. Cytotoxic chemotherapy and radiation therapy have shown little benefit in treating PEComa-NOS; mTOR inhibition is emerging as a treatment option. Conclusion. Progress has been made in understanding the natural history and molecular biology of PEComa-NOS. This review further clarifies risk of recurrence in this disease, allowing clinicians to better risk stratify patients. Further work should focus on applying this knowledge to making treatment decisions for patients with this disease