77 research outputs found

    Location of ser-4 near arg-2 on linkage group IV.

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    Location of ser-4 near arg-2 on linkage group IV

    Forward Masking Estimated by Signal Detection Theory Analysis of Neuronal Responses in Primary Auditory Cortex

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    Psychophysical forward masking is an increase in threshold of detection of a sound (probe) when it is preceded by another sound (masker). This is reminiscent of the reduction in neuronal responses to a sound following prior stimulation. Studies in the auditory nerve and cochlear nucleus using signal detection theory techniques to derive neuronal thresholds showed that in centrally projecting neurons, increases in masked thresholds were significantly smaller than the changes measured psychophysically. Larger threshold shifts have been reported in the inferior colliculus of awake marmoset. The present study investigated the magnitude of forward masking in primary auditory cortical neurons of anaesthetised guinea-pigs. Responses of cortical neurons to unmasked and forward masked tones were measured and probe detection thresholds estimated using signal detection theory methods. Threshold shifts were larger than in the auditory nerve, cochlear nucleus and inferior colliculus. The larger threshold shifts suggest that central, and probably cortical, processes contribute to forward masking. However, although methodological differences make comparisons difficult, the threshold shifts in cortical neurons were, in contrast to subcortical nuclei, actually larger than those observed psychophysically. Masking was largely attributable to a reduction in the responses to the probe, rather than either a persistence of the masker responses or an increase in the variability of probe responses

    Multidimensional Characterization and Differentiation of Neurons in the Anteroventral Cochlear Nucleus

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    Multiple parallel auditory pathways ascend from the cochlear nucleus. It is generally accepted that the origin of these pathways are distinct groups of neurons differing in their anatomical and physiological properties. In extracellular in vivo recordings these neurons are typically classified on the basis of their peri-stimulus time histogram. In the present study we reconsider the question of classification of neurons in the anteroventral cochlear nucleus (AVCN) by taking a wider range of response properties into account. The study aims at a better understanding of the AVCN's functional organization and its significance as the source of different ascending auditory pathways. The analyses were based on 223 neurons recorded in the AVCN of the Mongolian gerbil. The range of analysed parameters encompassed spontaneous activity, frequency coding, sound level coding, as well as temporal coding. In order to categorize the unit sample without any presumptions as to the relevance of certain response parameters, hierarchical cluster analysis and additional principal component analysis were employed which both allow a classification on the basis of a multitude of parameters simultaneously. Even with the presently considered wider range of parameters, high number of neurons and more advanced analytical methods, no clear boundaries emerged which would separate the neurons based on their physiology. At the current resolution of the analysis, we therefore conclude that the AVCN units more likely constitute a multi-dimensional continuum with different physiological characteristics manifested at different poles. However, more complex stimuli could be useful to uncover physiological differences in future studies

    A computational model of the temporal adaptation patterns of neurons in the ventral cochlear nucleus units

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    Size discrimination of transient sounds: perception and modelling

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    Humans are able to get an impression of the size of an object by hearing it resonate. While this ability is well described for periodic speech sounds we investigate here the ability to discriminate the size of non-periodic transient impact sounds. Three experiments were performed on normal listeners (n=19) to investigate the importance of the spectral cue in different frequency regions. Recordings from pulse resonance sounds made by a metal ball hitting polystyrene spheres of 5 different sizes were used in the experiments. Recordings were manipulated in order to show that the same cues used in speaker size discrimination are used for transient signals. Results show that the most prominent resonances are the most important cue, but frequencies above 8 kHz also contribute. The results are explained by physiologically inspired model of size discrimination that is based on the Auditory Image Model, and its key part is the Mellin transform. The model can predict which of two objects is bigger. We conclude that similar cues that are used for speaker size discrimination are important for transient sound
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