469 research outputs found
Nachweis von humanem Herpesvirus Typ 7 im Liquor cerebrospinalis neurologisch erkrankter Kinder mittels der Polymerase-Kettenreaktion
Humanes Herpesvirus Typ 7 wurde bisher mit verschiedenen fieberhaften Erkrankungen im
Kindesalter in Verbindung gebracht. Typischerweise kann HHV-7 exanthematöse Erkrankungenverursachen,
in wenigen FĂ€llen konnte ein Zusammenhang mit neurologischen Komplikationen
beobachtet werden. Unter anderem wurden FieberkrÀmpfe, temporÀre Hemiparesen
oder Meningitiden beschrieben. In dieser Arbeit sollte untersucht werden, ob HHV-7
im Liquor pÀdiatrischer Patienten mit verschiedenen neurologischen Erkrankungen auch ohne
Exanthema subitum nachgewiesen werden kann.
Dazu wurde ein hochsensitives Nachweisverfahren bestehend aus DNA-PrÀparation und
nested-PCR entwickelt. Nach Demonstration seiner hohen SensitivitÀt und SpezifitÀt wurden
mit dem Verfahren insgesamt 104 Liquorproben untersucht. Bei 6 Patienten konnte
HHV-7 DNA im Liquor nachgewiesen werden. Die KrankheitsverlÀufe dieser Patienten wurde
dargestellt und mit den wenigen, bisher in der Literatur beschriebenen Infektionen verglichen.
Parallel erfolgte ein Vergleich mit Infektionen des nÀchsten Verwandten HHV-6.
HHV-7 scheint sowohl bei der PrimÀrinfektion als auch bei der Reaktivierung in das ZNS
einzudringen und dort zu neurologischen Komplikationen fĂŒhren zu können. Dies geschieht
offensichtlich unabhÀngig vom Vorliegen eines Virusexanthems (z. B. Exanthema subitum).
Wie bei HHV-6 ist ein breites Spektrum an neurologischen Komplikationen möglich. In dieser
Untersuchung konnte erstmalig HHV-7 im Liquor von Patienten mit aseptischer Meningitis,
ADEM, Infektkrampf, einseitiger peripherer Fazialisparese und einseitiger Störung des N.
vestibularis nachgewiesen werden. Bei 3 Patienten lag dabei eine entzĂŒndliche LiquorverĂ€nderung
vor. Alle 6 HHV-7 positiven Patienten waren unter den 67 Patienten der Studiengruppe
zu finden. In keiner der 37 Liquorproben der Kontrollgruppe lieĂ sich das Virus detektieren.
Bei Patienten mit neurologischen Komplikationen im Rahmen fieberhafter viraler
Erkrankungen mit und ohne Exanthem muĂ an HHV-7 als Ursache gedacht werden
Body modifications in borderline personality disorder patients: prevalence rates, link with non-suicidal self-injury, and related psychopathology
Background: Borderline Personality Disorder (BPD) is a potentially severe personality disorder, characterized by difficulties in emotion regulation and control of behaviors. It is often associated with non-suicidal self-injury (NSSI). Borderline personality features have also been linked to body modifications (BMs). However, the prevalence of BMs, the link between BMs and NSSI, and between BMs and several psychopathology dimensions (e.g. borderline severity, emotion regulation, impulsivity âŠ) remains understudied in patients with BPD. This study aims to fill this gap, and to provide further evidence on the link between NSSI and BMs. Methods: We used data from a psychiatric outpatient center located in Switzerland (n = 116), specialized in the assessment and treatment of BPD patients. Patients underwent several semi-structured interviews and self-report psychometric scales at the arrival, and the data were retrospectively analyzed. Results: We found that 70.69% of the patients had one piercing or more, and 69.83% were tattooed. The total score of body modifications and the total number of piercings score of piercings were significantly positively associated with NSSI and the SCID BPD total score. The association with the SCID score was mainly driven by the âsuicide and self-damaging behaviorsâ item and the âchronic feeling of emptinessâ item. A significant association was found between total number of piercings and emotion dysregulation. On the other hand, the self-reported percentage of body covered by tattoos score was specifically associated with the sensation seeking subscale of the UPPS-P. Conclusion: This study provides evidence on the prevalence of BMs in BPD patients, and on the link between BMs and NSSI in this population, suggesting a role of emotion regulation in the link between both constructs. These results also suggests that tattoos and piercings may be differentially linked to specific underlying psychological mechanisms. This calls for further considerations of body modifications in the assessment and care of BPD patients
Managing change in BIM-Level 2 projects: benefits, challenges, and opportunities
Purpose: The aim of this paper is to validate perceived benefits and challenges of BIM-Level 2 in managing change in projects and identify opportunities for enhancing these benefits and reducing the challenges. This research is timely because, these benefits and challenges remain largely unvalidated following the passing of the BIM-Level 2 mandate in the UK, and the opportunities for enhancing the benefits and reducing challenges remain relatively unexplored. Design/methodology/approach:
To achieve the aim, questionnaires were sent to BIM-Level 2 practitioners in the UK; in all, 41 responses were received. Following that, interviews with 10 BIM practitioners were carried out to identify opportunities for reducing challenges and increasing benefits. Findings: From the findings, the benefits from the literature were all validated. Beyond these, some emergent benefits were identified, such as cost saving and risk reduction. Most challenges from the literature were validated with emergent challenges identified, largely to do with the social dimension in the BIM-Level 2 process. Opportunities identified to enhance benefits and reduce challenges were mainly socially driven. These opportunities were classified as either reactive or proactive. Research limitations/implications: Opportunities for reducing challenges and increasing benefits identified from this research can inform the change management processes in BIM-Level 2.
Practical implications: Findings show the processes and requirements for managing change in BIM-level 2. Social implications:
The identification of behaviours reveals the social requirements for BIM-level 2.
Originality/value: This research identifies opportunities required to reconstruct the change management process in BIM-Level 2. This forms a basis for future work to explore the antecedents of these social requirements
Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study
The aim of the study was to assess health-related quality of life (HRQoL) among metastatic soft tissue (mSTS) or bone sarcoma (mBS) patients who had attained a favourable response to chemotherapy. We employed the EORTC QLQ-C30, the 3-item Cancer-Related Symptoms Questionnaire, and the EQ-5D instrument. HRQoL was evaluated overall and by health state in 120âmSTS/mBS patients enrolled in the SABINE study across nine countries in Europe and North America. Utility was estimated from responses to the EQ-5D instrument using UK population-based weights. The mean EQ-5D utility score was 0.69 for the pooled patient sample with little variation across health states. However, patients with progressive disease reported a clinically significant lower utility (0.56). Among disease symptoms, pain and respiratory symptoms are common. This study showed that mSTS/mBS is associated with reduced HRQoL and utility among patients with metastatic disease
The 1989 and 2015 outbursts of V404 Cygni: a global study of wind-related optical features
The black hole transient V404 Cygni exhibited a bright outburst in June 2015
that was intensively followed over a wide range of wavelengths. Our team
obtained high time resolution optical spectroscopy (~90 s), which included a
detailed coverage of the most active phase of the event. We present a database
consisting of 651 optical spectra obtained during this event, that we combine
with 58 spectra gathered during the fainter December 2015 sequel outburst, as
well as with 57 spectra from the 1989 event. We previously reported the
discovery of wind-related features (P-Cygni and broad-wing line profiles)
during both 2015 outbursts. Here, we build diagnostic diagrams that enable us
to study the evolution of typical emission line parameters, such as line fluxes
and equivalent widths, and develop a technique to systematically detect outflow
signatures. We find that these are present throughout the outburst, even at
very low optical fluxes, and that both types of outflow features are observed
simultaneously in some spectra, confirming the idea of a common origin. We also
show that the nebular phases depict loop patterns in many diagnostic diagrams,
while P-Cygni profiles are highly variable on time-scales of minutes. The
comparison between the three outbursts reveals that the spectra obtained during
June and December 2015 share many similarities, while those from 1989 exhibit
narrower emission lines and lower wind terminal velocities. The diagnostic
diagrams presented in this work have been produced using standard measurement
techniques and thus may be applied to other active low-mass X-ray binaries.Comment: Accepted for publication in MNRAS. 23 pages paper, plus a 9 pages
appendix with extra tables and figures. 18 figures are included in the paper
and 8 in the appendi
The complexity of sediment recycling as revealed by common Pb isotopes in K-feldspar
© 2018 China University of Geosciences (Beijing) and Peking University. Detrital zircon UâPb geochronology has become the gold standard in evaluating source to sink relationships in sedimentary basins. However, the physical and chemical robustness of zircon, which make it such a useful mineral for provenance studies, is also a hindrance as zircon can be recycled through numerous sedimentary basins, thus obscuring the first cycle source to sink relationship. An elegant approach to addressing this potential issue is to compare the Pb isotope composition of detrital K-feldspar, a mineral which is unlikely to survive more than one erosion-transport-deposition cycle, with that of magmatic K-feldspar from potential basement source terranes. Here we present new in situ Pb isotope data on detrital K-feldspar from two Proterozoic arkosic sandstones from Western Australia, and magmatic K-feldspar grains from potential igneous source rocks, as inferred by the age and Hf isotope composition of detrital zircon grains. The data indicate that the detrital zircon and K-feldspar grains could not have been liberated from the same source rocks, and that the zircon has most likely been recycled through older sedimentary basins. These results provide a more complete understanding of apparently simple source to sink relationships in this part of Proterozoic Western Australia
The transiting multi-planet system HD3167: a 5.7 MEarth Super-Earth and a 8.3 MEarth mini-Neptune
HD3167 is a bright (V=8.9 mag) K0V star observed by the NASA's K2 space
mission during its Campaign 8. It has been recently found to host two small
transiting planets, namely, HD3167b, an ultra short period (0.96 d)
super-Earth, and HD3167c, a mini-Neptune on a relatively long-period orbit
(29.85 d). Here we present an intensive radial velocity follow-up of HD3167
performed with the FIES@NOT, [email protected], and HARPS-N@TNG spectrographs. We
revise the system parameters and determine radii, masses, and densities of the
two transiting planets by combining the K2 photometry with our spectroscopic
data. With a mass of 5.69+/-0.44 MEarth, radius of 1.574+/-0.054 REarth, and
mean density of 8.00(+1.0)(-0.98) g/cm^3, HD3167b joins the small group of
ultra-short period planets known to have a rocky terrestrial composition.
HD3167c has a mass of 8.33 (+1.79)(-1.85) MEarth and a radius of
2.740(+0.106)(-0.100) REarth, yielding a mean density of 2.21(+0.56)(-0.53)
g/cm^3, indicative of a planet with a composition comprising a solid core
surrounded by a thick atmospheric envelope. The rather large pressure scale
height (about 350 km) and the brightness of the host star make HD3167c an ideal
target for atmospheric characterization via transmission spectroscopy across a
broad range of wavelengths. We found evidence of additional signals in the
radial velocity measurements but the currently available data set does not
allow us to draw any firm conclusion on the origin of the observed variation.Comment: 18 pages, 11 figures, 5 table
- âŠ