719 research outputs found
Hebrew and North West Semitic: Reflections on the Classification of the Semitic Languages
with reference to the lndo-European languages. For more than a century, it has been customary to view them from the angle of both the family-tree theory and the wave hypothesis. As far as the continuity of the territory of Indo-European languages can be posited, it is the wave hypothesis that best ex-plains the relation of the languages involved. Yet the position of the Indo-European languages in historical times presupposes migrations, and the lin-guistic situation due to them is best interpreted in the light of the family-tree theory.1 2. One immediately recognizes that the wave hypothesis is much more con-vincing if applied to the Semitic languages. Even a hasty glance at the map of the Semitic tongues, in the past and in our own day, more or less reveals the continuity of the domain of these languages. Moreover, close contact between various Semitic idioms is well attested throughout history, the more so since Semitic languages surprisingly often were established as linguae francae, used in preference to the spoken language. This was the case not only with the language of a great power, viz., Akkadian, in which, e.g., Canaanite princes wrote their diplomatic correspondence with Pharaoh around 1400 B.C.E. (the Tel el-Amama letters), but also with Phoenician, used in Karatepe and Zen
On Pausal Lengthening, Pausal Stress Shift, Philippi's Law and Rule Ordering in Biblical Hebrew
Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel
No biomarker panel is established for prediction of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), a major complication of allogeneic stem cell transplantation (alloSCT). We compared the potential of the Endothelial Activation and Stress Index (EASIX), based on lactate dehydrogenase, creatinine, and thrombocytes, with that of the SOS/VOD CIBMTR clinical risk score to predict SOS/VOD in two independent cohorts. In a third cohort, we studied the impact of endothelium-active prophylaxis with pravastatin and ursodeoxycholic acid (UDA) on SOS/VOD risk. The cumulative incidence of SOS/VOD within 28 days after alloSCT in the training cohort (Berlin, 2013-2015, n=446) and in the validation cohort (Heidelberg, 2002-2009, n=380) was 9.6% and 8.4%, respectively. In both cohorts, EASIX assessed at the day of alloSCT (EASIX-d0) was significantly associated with SOS/VOD incidence (p<0.0001), overall survival (OS) and non-relapse mortality (NRM). In contrast, the CIBMTR score showed no statistically significant association with SOS/VOD incidence, and did not predict OS and NRM. In patients receiving pravastatin/UDA, the cumulative incidence of SOS/VOD was significantly lower at 1.7% (p<0.0001, Heidelberg, 2010-2015, n=359) than in the two cohorts not receiving pravastatin/UDA. The protective effect was most pronounced in patients with high EASIX-d0. The cumulative SOS/VOD incidence in the highest EASIX-d0 quartiles were 18.1% and 16.8% in both cohorts without endothelial prophylaxis as compared to 2.2% in patients with pravastatin/UDA prophylaxis (p<0.0001). EASIX-d0 is the first validated biomarker for defining a subpopulation of alloSCT recipients at high risk for SOS/VOD. Statin/UDA endothelial prophylaxis could constitute a prophylactic measure for patients at increased SOS/VOD risk
Quantized Nambu-Poisson Manifolds in a 3-Lie Algebra Reduced Model
We consider dimensional reduction of the Bagger-Lambert-Gustavsson theory to
a zero-dimensional 3-Lie algebra model and construct various stable solutions
corresponding to quantized Nambu-Poisson manifolds. A recently proposed Higgs
mechanism reduces this model to the IKKT matrix model. We find that in the
strong coupling limit, our solutions correspond to ordinary noncommutative
spaces arising as stable solutions in the IKKT model with D-brane backgrounds.
In particular, this happens for S^3, R^3 and five-dimensional Neveu-Schwarz
Hpp-waves. We expand our model around these backgrounds and find effective
noncommutative field theories with complicated interactions involving
higher-derivative terms. We also describe the relation of our reduced model to
a cubic supermatrix model based on an osp(1|32) supersymmetry algebra.Comment: 22 page
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