341 research outputs found

    TangiPaint: Interactive tangible media

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    Currently, there is a wide disconnection between the real and virtual worlds in computer graphics. Art created with textured paints on canvases have visual effects which naturally supplement simple color. Real paint exhibits shadows and highlights, which change in response to viewing and lighting directions. The colors interact with this environment and can produce very noticeable effects. Additionally, the traditional means of human-computer interaction using a keyboard and mouse is unnatural and inefficient---gestures and actions are not performed on the objects themselves. These visual effects and natural interactions are missing from digital media in the virtual world. The absence of these visual characteristics disconnects users from their content. Our research looks into simulating these missing pieces and reconnecting users. TangiPaint is an interactive, tangible application for creating and exploring digital media. It gives the experience of working with real materials, such as oil paints and textured canvases, on a digital display. TangiPaint implements natural gestures and allows users to directly interact with their work. The Tangible Display technology allows users to tilt and reorient the device and screen to see the subtle gloss, shadow, and impasto lighting effects of the simulated surface. To simulate realistic lighting effects we use a Ward BRDF illumination model. This model is implemented as an OpenGL shader program. Our system tracks the texture and relief of a piece of art by saving topographical information. We implement height fields, normal vectors, and parameter maps to store this information. These textures are submitted to the lighting model that renders a final product. TangiPaint builds on previous work and applications in this area, but is the first to integrate these aspects into a single software application. The system is entirely self-contained and implemented on the Apple iOS platforms, the iPhone, iPad, and iPod Touch. No additional hardware is required and the interface is easy to learn and use. TangiPaint is a step in the direction of interactive digital art media that looks and behaves like real materials

    Genetic Editing Out the Tumor Growth Supressor Gene TRM9L in Colorectal Cancer Models Using CRISPR-Cas9

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    Clustered regularly interspaced short palindromic repeats (CRISPR) is a precise genetic engineering tool for genome editing. CRISPR utilizes guide RNA (gRNA) to find specific DNA sequences followed by a Cas9 nuclease to cut the DNA at a specific site. TRM9L is a tumor growth-suppresser gene that restricts the growth of some colorectal cancer cells by upregulating LIN9 expression. TRM9L expression is lost in some late stage colorectal cancers and cancer models (SW620). SW480 colorectal cancer cells express TRM9L and these cells are considered to be at the beginning of colorectal cancer development. The goal of my project was to use genetic engineering approaches to remove TRM9L from early stage colorectal cancer cells (SW480) and to then determine the effect on tumor growth. In this project, CRISPR constructs were synthesized, hybridized, and ligated to an expression vector. The hybridized vector underwent bacterial-facilitated replication and was then harvested via plasmid purification. The plasmids were gene sequenced and then transfected into a growing culture of SW480 cells. After a month of plasmid-inclusion growth, the cell cultures will be analyzed for growth effects. My work is important because it will develop new tools for use in colorectal cancer research, a disease that claims over 50,000 lives each year

    Present net worth and internal rate of return: A note on equivalence in use

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    Present net worth and internal rate of return are frequently used for ranking investment alternatives. The relative merits and limitations of the two criteria are discussed at length in numerous journal articles and texts. For analysts wishing to present consistent project comparisons, the issue is not which criterion is superior, but when are they equivalent. In this article, conditions for equivalence in use are outlined under alternative assumptions. Although the conditions appear complex, they are not unduly restrictive

    Non-user benefits emanating from enhanced water flow to the Yala Protected Area Complex

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    Water is a multiple use resource. Increasing scarcity and competition from various sectors is an important dimension to be considered in its management. Understanding the value of water to different water uses is, therefore, necessary to assist decision-making in water allocation among sectors. Although water used in agriculture can be valued using production function approaches, such direct valuation methods are not available for the environmental uses of water. This paper uses non-market valuation methods to estimate the economic value of a committed flow through a unique ecosystem, the Yala Protected Area Complex (YPC). The Yala Protected Area Complex is an important wildlife refuge situated in south-eastern Sri Lanka. Its large land extent, undisturbed nature, and abundance and diversity of fauna contribute to its uniqueness. The fact that the YPC is also the most visited national park in Sri Lanka is partially a result of this uniqueness. However, maintenance of the park’s ecosystem depends on the flow of the Menik Ganga. This flow is regulated by the Veheragala Reservoir Project, and there is now discussion of reducing flow into the park by about half of the current level. The proposed plan ensures dry season flow into the YPC and, therefore, has been deemed acceptable. However, there is a possibility that farmers will demand further water releases during the dry season which could in turn endanger the planned downstream water releases. So there is a potential trade-off between environmental and irrigation uses of water. A willingness to pay (WTP) survey was conducted in ten districts in Sri Lanka during the fourth quarter of 2008 to estimate the WTP of the general population of the country towards maintaining this important environmental resource. In the hypothetical market presented, participants were told of the need for financial contributions from the general public to ensure the release of a minimum downstream flow commitment of 50 MCM. Participants were also informed of how this flow would enhance the ecosystem of the YPC. A single bound dichotomous choice contingent valuation approach was used as the elicitation format. Nonobligatory voluntary contributions were solicited towards a trust fund that could be used to ensure release of the required quantity of water downstream during dry months. According to the results of a binary logistic regression, income, age, and religious attachments are important factors affecting the decision to contribute to environmental flow maintenance to the YPC. Sixty-five percent of respondents were willing to pay something to ensure the maintenance of an adequate environmental flow in the YPC. The estimated mean WTP for water releases to enhance the YPC is Sri Lankan Rupees (SLR) 435 per year. Over the requested payment horizon of 10 years, the present value of aggregate WTP from the Sri Lankan population to enhance the ecosystem of the YPC is SLR 12 billion. This quantity greatly surpasses the present value of net benefits from rice farming estimated at SLR 0.64 billion, which would be generated if the same quantity of water was used for irrigation for 10 years (assuming current prices and input intensities). Thus, there is a clear opportunity for national welfare gain by ensuring adequate flow in YPC.Length: pp.37-47Water useMultiple useWildlifeHabitatsEcosystemsIrrigation waterWater allocation

    Non-user benefits emanating from enhanced water flow to Yala Protected Area Complex. Abstract only

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    EcosystemsWater resource managementMultiple useDecision makingWater allocationEnvironmental flows

    The core techniques of Morenian psychodrama: A systematic review of literature

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    The original theory of psychodrama proposed by Moreno in 1921 has been adjusted and re-interpreted by several authors over the last three decades. This resulted in the proliferation of techniques whose definitions and contexts of application are unclear and poorly documented in the literature. The purpose of this review was three-fold: (1) to identify the psychodramatic techniques currently used for research and clinical purposes, (2) to extract and create a list of core techniques which are consensually used by psychodramatists, and which reflect the main principles of the Morenian theory of psychodrama, and (3) to propose an operationalised definition of the core psychodramatic techniques identified. To achieve this, a systematic review was conducted, according to the PRISMA guidelines (Moher et al., 2009). The search was conducted between June and September of 2012 in the main electronic databases (e.g., PubMed, Embase, PsychINFO) and using the following keywords: “psychodrama,” “group psychotherapy,” “experiential psychotherapy,” “Moreno,” “intervention,” and “techniques.” Fifty-six techniques were extracted from the 21 papers selected for review. Of these, a preliminary list of 30 techniques was selected, which was reduced to a total of 11 core techniques: soliloquy, double, mirror, role reversal, resistance interpolation, sculpture, social atom, intermediate objects, games, sociometry, role training. The credibility of this final core list was first checked with an expert in Morenian psychodrama, and later discussed with a network of 22 European psychodramatists to ensure full consensus. Overall, this review provides a contemporary framework for psychodramatists that reconciles the current approaches to psychodrama with the core techniques proposed by Moreno, and updates the definitions of these techniques, by merging the interpretations of different experts in the field. To have a list of core techniques which is consensually accepted from an international point of view is paramount not only for future research, but also for training purposes. The implications of this review for clinical practice are also discussed

    Aktivierung angeborener Immunmechanismen in der Haut durch Amyloid β

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    Use and Effectiveness of Washington State's Extension Forest Stewardship Program

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    This paper describes the use by family forest landowners of educational programs provided by Washington State University Cooperative Extension (WSUCE), and the associated use of technical assistance programs provided by state and federal agencies and the private sector. Approximately 100,000 family forest owners controlled 19% or over 1.2 M ha of Washington's forestland and accounted for 29% of the timber harvested in the state on a volume basis in 1998. A variety of public and private assistance and education programs are available to encourage and help family forest owners manage their forests. In 1999 a mail survey was conducted to evaluate use and effectiveness of Washington's family forest assistance and education programs. Over half of the 872 responding family forest landowners had contact with an extension educator, program or educational material, and about three quarters of these respondents gave an overall rating of the usefulness of extension programs and materials as good or excellent. Respondents attending WSUCE forestry educational programs have larger median land ownership size, are older, have owned their forests longer, have a higher rate of absentee ownership, and are better educated than non-users. They are more likely to actively manage their forests for timber production and exhibit a clearer understanding of the multiple-use capabilities of their forests

    Aktivierung angeborener Immunmechanismen in der Haut durch Amyloid β

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    Ecosystem Management and Nonindustrial Private Forest Landowners in Washington State, USA

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    Washington's non-industrial private forest (NIPF) landowners control 1.2 M ha, or nearly 20%, of the forestland in Washington State. Results of a mail survey suggest that educated and informed NIPF landowners are more likely to show interest in ecosystem-based management programs. NIPF respondents in Washington State indicated an appreciation for the temporal vision and landscape perspective crucial to understanding the foundation of ecosystem management. It is concluded that public agencies need to involve private landowners in ecosystem-based projects by using a more 'place'-based cross-boundary management approach. NIPF landowners must be actively involved in the decision-making so that the process, for them, is one of self-governance. Providing landowners with opportunities for education and assistance may offer the best prospects for achieving ecosystem management objectives across diverse ownerships
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