Eficacia de las ortesis plantares y la calzadoterapia en pacientes con Hallux Rígidus

[Resumen] OBJETIVO: Revisión bibliográfica orientada a exponer la evidencia científica existente en relación al empleo y eficacia de las ortesis plantares y la calzadoterapia en pacientes con Hallux RÍgidus. METODOLOGÍA: Se realizó una búsqueda bibliográfica en seis de las bases de datos más recomendadas en ciencias de la salud: Biblioteca Cochrane, PubMed, Scopus, Dialnet, Enfispo y Scielo seleccionando publicaciones entre los años 2005 y 2016, durante los meses de Enero y Abril de 2016. RESULTADOS: Se obtuvieron un total de 114 publicaciones desde el año 2005 hasta la actualidad, de las cuales se seleccionaron 18 que cumplían los criterios de inclusión pertinentes. Como resultado generalizado se extrae que tanto la calzadoterapia como las ortesis plantares son tratamientos eficaces en pacientes que padecen Hallux Rígidus. CONCLUSIONES: El tratamiento conservador con ortesis plantares y modificaciones en el calzado se considera de primera elección en las fases iniciales de Hallux RÍgidus. Con el objetivo de mejorar la sintomatología y aumentar la dorsiflexión del hallux, la extensión de Morton y un zapato con suela en balancín son las opciones que más se valoran en los estudios y que pueden resultar favorables para hacer atender a esta patología.[Resumo] OBXECTIVO: Revisión bibliográfica orientada a expoñer a evidencia científica existente respecto ao uso e eficacia das órteses plantares e a calzadoterapia en pacientes con Hallux RÍgidus. METODOLOXÍA: A procura bibliográfica foi realizada en seis das bases de datos máis recomendadas en ciencias da saúde: Biblioteca Cochrane, PubMed, Scopus, Dialnet, Enfispo e Scielo, seleccionando publicacións entre os anos 2005 e 2016, durante os meses de xaneiro e abril do 2016. RESULTADOS: Obtivéronse un total de 114 publicacións dende o ano 2005 ata a actualidade, das cales seleccionáronse 18 que cumprían os criterios de inclusión pertinentes. Como resultado xeneralizado, extráese que tanto a calzadoterapia como as órteses plantares son tratamentos eficaces en pacientes que padecen Hallux Rígidus. CONCLUSIÓNS: O tratamento conservador con órteses plantares e modificacións no calzado considéranse de primeira opción nas fases iniciais do Hallux RÍgidus. Co obxectivo de mellorar os síntomas e aumentar a dorsiflexión do hallux, a extensión de Morton e un zapato con sola en balancín son as opcións que máis se valoran nos estudos e que poden resultar favorables para atender a esta patoloxía.[Abstract] OBJECTIVE: Bibliographic review aimed to expose the current scientific evidence in relation to the use and effectiveness of foot orthosis and footwear in patients with Hallux Rigidus. METHODOLOGY: A literature search was carried out in six of the databases more recommended in the health sciences: Cochrane Library, PubMed, Scopus, Dialnet, Enfispo and Scielo selecting publications between the years 2005 and 2016, during the months of January and April 2016. RESULTS: A total of 114 publications were obtained from 2005 until the present day, of which 18 were selected.of those meeting the relevant inclusion criteria. As a generalized result is extracted that footwear and foot orthoses are effective treatments in patients suffering from Hallux Rígidus. CONCLUSIONS: Conservative treatment with foot orthoses and modifications in footwear is considered first-choice in the initial phases of Hallux Rigidus. In order to improve the symptoms and increase the dorsiflexion of the hallux, the extension of Morton and a shoe with a rocker sole are the options that are more valued in the studies, and that may be favorable to cater to this pathology.Traballo fin de grao (UDC.FEP). Podoloxía. Curso 2015/201

Percepciones, sensaciones y experiencias de un grupo de inmigrantes sadenses acerca de los servicios sanitarios.

[Resumen] Introducción: En los últimos años, España ha sido receptora de numerosos flujos migratorios por lo que nos encontramos ante una nueva sociedad multicultural. Así, con el cambio de población atendida en los centros sanitarios españoles, se han incrementado los estudios destinados a analizar aspectos vinculados con los servicios de salud y la inmigración. La situación socioeconómica, así como también aspectos de carácter cultural, biológicos y factores asociados a la migración en sí son barreras que pueden incidir tanto en la salud como en la atención y accesibilidad a los servicios sanitarios de nuestro país por parte de estos colectivos. Por ello, sería oportuno a la par que beneficioso conocer percepciones, sensaciones y experiencias desde la perspectiva inmigrante con respecto al sistema de salud español, lo que ayudaría a crear nuevas estrategias e intervenciones para facilitar el acceso a los servicios y dar una atención más eficiente, individualizada y de calidad. Objetivo general: Conocer y analizar percepciones y sensaciones de un grupo de inmigrantes residentes en el municipio de Sada referente al sistema de salud español. Objetivos específicos: • Comprobar el grado de satisfacción de dichos inmigrantes con el sistema de salud español • Conocer diferentes experiencias que han vivido al acudir a su correspondiente Centro de Salud u hospital • Valorar la accesibilidad que tienen dichos inmigrantes al sistema sanitario • Analizar la percepción acerca del trato recibido en el sistema sanitario. Metodología: Se llevará a cabo un estudio cualitativo fenomenológico, con la realización de entrevistas abiertas en profundidad a un cupo de inmigrantes latinoamericanos residentes en la localidad coruñesa de Sada.[Abstract] Introduction: For the past years, Spain has been the recipient of numerous migratory flows, so we are facing a new multicultural society. In this way, with the change of population who is attended in the Spanish health centres, the studies destined to analyse the aspects related to health care and immigration have increased. Socioeconomic status, as well as cultural and biological aspects and factors associated with migration itself are barriers that can influence as much to health as to care and accessibility to health care services in our country on the part of these groups. Therefore, it would be convenient on the same level as beneficial to know perceptions, emotions and experiences from the immigrant perspective with regard to Spanish health system, which would help to create new strategies and interventions in order to make access to services easier and provide more efficient, individualized and high quality care. General objective: Understand and analyse perceptions and emotions of a group of immigrants living in the town of Sada concerning the Spanish health system. Specific objectives: • Check the satisfaction degree with the Spanish health system of those immigrants • Get to know different experiences they have lived while going to their respective health centre or hospital • Value the accessibility to health system that those immigrants have • Analyse the perception about the received treatment in the health system. Methodology: It will be carried out a phenomenological qualitative study, with an in-depth conduction of opened interviews to a Latin American immigration quota residing in the coruñesa town of Sada.Traballo fin de grao (UDC.FEP). Enfermarí

Lesiones deportivas en la extremidad inferior de niños y adolescentes que practican fútbol: proyecto de investigación

[Resumen] Introducción: el ejercicio físico en la etapa infantil y adolescente es fundamental para un correcto desarrollo físico en los más jóvenes. Dicha actividad ha provocado, en los últimos años, un incremento significativo de las lesiones en los niños. La lesión deportiva se ha definido como como todo accidente o disfunción física acaecido durante la práctica deportiva, o como consecuencia directa de ella. Objetivos: el objetivo principal de la propuesta de investigación es determinar la prevalencia y el tipo de lesiones deportivas en la extremidad inferior en jugadores de 10 a 18 años que practiquen fútbol federado en la comarca de “As Mariñas”. También se pretende valorar las variables asociadas a la presencia de lesión con el fin de conocer el perfil de riesgo de jugador predisponente a sufrir patologías en el miembro inferior. Metodología y análisis: se llevará a cabo un estudio descriptivo observacional transversal. Se desarrollará desde enero de 2021 hasta abril de 2022 en la comarca de “As Mariñas”, con un número total de 134 jugadores de fútbol. Se contabilizará la presencia de lesión deportiva como variable principal y demás variables clínicas, sociodemográficas y deportivas. Se utilizarán análisis bivariantes y multivariantes para determinar las variables asociadas con la presencia de lesión deportiva en los jugadores. Ética y difusión: este estudio será sometido a valoración del Comité de Ética de Investigación de Galicia y sus resultados serán difundidos en revistas nacionales e internacionales, y en jornadas y congresos científicos.[Resumo] Introducción: o exercicio físico na etapa infantil e adolescente é fundamental para un correcto desenvolvemento físico nos máis novos. Dita actividade provocou, nos últimos anos, un incremento significativo das lesións nos nenos. A lesión deportiva definiuse como todo accidente ou disfunción física ocurrida durante a práctica deportiva, ou como consecuencia directa dela. Obxectivo: o obxectivo principal da proposta de investigación é determinar a prevalencia e o tipo de lesións deportivas na extremidade inferior en xogadores de 10 a 18 anos que practiquen fútbol federado na comarca de “As Mariñas”. Tamén se pretenden valorar as variables asociadas á presencia de lesión co fin de coñecer o perfil de risco do xogador predispoñente a sufrir patoloxías no membro inferior, debido ás consecuencias que pode conlevar nun futuro. Metodoloxía e análisis: levarase a cabo un estudo descriptivo observacional transversal. Desenvolverase dende Xaneiro de 2021 ata Abril de 2022 na comarca de “As Mariñas”, cun número total de 134 xogadores. Contabilizarase a presenza de lesión deportiva como variable principal e demais variables clínicas, sociodemográficas e deportivas. Utilizaranse análisis bivariantes e multivariantes pra determinar as variables asociadas coa presenza de lesión deportiva nos xogadores. Ética e difusión: este estudo será sometido a valoración do Comité de Ética de Investigación de Galicia e os seus resultados serán difundidos en revistas nacionais e internacionais, e en xornadas e congresos científicos.[Abstract] Introduction: Physical exercise during childhood and adolescence is essential for the proper physical development of younger generations. However, physical activity may increase injuries among children. Sports injury is defined as any accident or physical dysfunction that occurs during sports practice, or as a direct consequence of it. Objective: the main objective of this protocol is to determine the prevalence and type of lower limb sports injuries among players aged 10 to 18 years who practice federated football in the region of "As Mariñas". Additionally, associations between injuries and sociodemographic factors will be explored in order to draw a risk profile of the player susceptible to suffer lower limb sports injuries. Methodology and analysis: a cross-sectional observational descriptive study will be carried out. It will take place from January 2021 to April 2022 in the "As Mariñas" region, and it will include a total sample of 134 young football players. The main variable of study will be the presence of lower limb sports injury. Additional clinical, sociodemographic and sports variables will be recorded. Bivariate and multivariate analyzes will be used to determine the variables associated with the presence of sports injury in football players. Ethics and dissemination: this study will be submitted to the Galician Research Ethics Committee for evaluation and its results will be disseminated in national and international journals, and in scientific conferences and meetings.Traballo fin de grao (UDC.FEP). Podoloxía. Curso 2019/202

P4P: a peptidome-based strain-level genome comparison web tool

Peptidome similarity analysis enables researchers to gain insights into differential peptide profiles, providing a robust tool to discriminate strain-specific peptides, true intra-species differences among biological replicates or even microorganism-phenotype variations. However, no in silico peptide fingerprinting software existed to facilitate such phylogeny inference. Hence, we developed the Peptidomes for Phylogenies (P4P) web tool, which enables the survey of similarities between microbial proteomes and simplifies the process of obtaining new biological insights into their phylogeny. P4P can be used to analyze different peptide datasets, i.e. bacteria, viruses, eukaryotic species or even metaproteomes. Also, it is able to work with whole proteome datasets and experimental mass-to-charge lists originated from mass spectrometers. The ultimate aim is to generate a valid and manageable list of peptides that have phylogenetic signal and are potentially sample-specific. Sample-to-sample comparison is based on a consensus peak set matrix, which can be further submitted to phylogenetic analysis. P4P holds great potential for improving phylogenetic analyses in challenging taxonomic groups, biomarker identification or epidemiologic studies. Notably, P4P can be of interest for applications handling large proteomic datasets, which it is able to reduce to small matrices while maintaining high phylogenetic resolution. The web server is available at http://sing-group.org/p4p.Spanish ‘Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad’ [AGL2013-44039R]; Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020[POCI-01-0145-FEDER-006684];INOU16-05project from the University of Vigo; Fundación AECC. Funding for open access charge: Spanish ‘Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad’ [AGL2013-44039R].info:eu-repo/semantics/publishedVersio

In silico prediction reveals the existence of potential bioactive neuropeptides produced by the human gut microbiota

This work reports on a large-scale potential neuropeptide activity screening in human gut microbiomes deposited in public databases. In our experimental approach, the sequences of the bioactive peptides collected in the MAHMI database, mainly predicted as immunomodulatory or antitumoral, were crossed with those of the neuroactive/digestive peptides. From 91,325,790 potential bioactive peptides, only 581 returned a match when crossed against the 5949 neuroactive peptides from the NeuroPep database and the 15 digestive hormones. Relevant bacterial taxa, such as Ruminococcus sp., Clostridium sp. were found among the main producers of the matching sequences, and many of the matches corresponded to adiponectin and the hormone produced by adipocites, which is involved in glucose homeostasis. These results show, for the first time, the presence of potentially bioactive peptides produced by gut microbiota members over the nervous cells, most notably, peptides with already predicted immunomodulatory or anti-inflammatory activity. Classical (Lactobacillus sp.) and next-generation (Faecalibacterium sp.) probiotics are shown to produce these peptides, which are proposed as a potential mechanism of action of psychobiotics. Our previous experimental results showed that many of these peptides were active when incubated with immune cells, such as dendritic cells, so their effect over the nervous system innervating the gut mucosa holds significant potential and should be explored.Spanish “Programa Estatal de Investigación, Desarrollo e Inovación Orientada a los Retos de la Sociedad” (Grant AGL2016-78311-R); the Asociación Española Contra el Cancer (“Obtención de péptidos bioactivos contra el Cáncer Colo-Rectal a partir de secuencias genéticas de microbiomas intestinales”, grant PS-2016). This study was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER006684). SING group thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure. This work was partially supported by the Asturias Regional Plan I+D+i for research groups (FYCYT-IDI/2018/000236) and by the Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia) under the scope of the strategic funding of ED431C2018/55-GRC Competitive Reference Groupinfo:eu-repo/semantics/publishedVersio

Computational prediction of the bioactivity potential of proteomes based on expert knowledge

Advances in the field of genome sequencing have enabled a comprehensive analysis and annotation of the dynamics of the protein inventory of cells. This has been proven particularly rewarding for microbial cells, for which the majority of proteins are already accessible to analysis through automatic metagenome annotation. The large-scale in silico screening of proteomes and metaproteomes is key to uncover bioactivities of translational, clinical and biotechnological interest, and to help assign functions to certain proteins, such as those predicted as hypothetical. This work introduces a new method for the prediction of the bioactivity potential of proteomes/metaproteomes, supporting the discovery of functionally relevant proteins based on prior knowledge. This methodology complements functional annotation enrichment methods by allowing the assignment of functions to proteins annotated as hypothetical/putative/uncharacterised, as well as and enabling the detection of specific bioactivities and the recovery of proteins from defined taxa. This work shows how the new method can be applied to screen proteome and metaproteome sets to obtain predictions of clinical or biotechnological interest based on reference datasets. Notably, with this methodology, the large information files obtained after DNA sequencing or protein identification experiments can be associated for translational purposes that, in cases such as antibiotic-resistance pathogens or foodborne diseases, may represent changes in how these important and global health burdens are approached in the clinical practice. Finally, the Sequence-based Expert-driven pRoteome bioactivity Prediction EnvironmENT, a public Web service implemented in Scala functional programming style, is introduced as means to ensure broad access to the method as well as to discuss main implementation issues, such as modularity, extensibility and interoperability.This work was supported by the Spanish “Programa Estatal de Investigación, Desarrollo e Inovación Orientada a los Retos de la Sociedad” (grant AGL2013-44039R); the Asociación Española Contra el Cancer (“Obtención de péptidos bioactivos contra el Cáncer Colo-Rectal a partir de secuencias genéticas de microbiomas intestinales”, grant PS2016). This study was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145- FEDER006684). SING group thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure.info:eu-repo/semantics/publishedVersio

Enabling the Internet of Mobile Crowdsourcing Health Things: A Mobile Fog Computing, Blockchain and IoT Based Continuous Glucose Monitoring System for Diabetes Mellitus Research and Care

[Abstract] Diabetes patients suffer from abnormal blood glucose levels, which can cause diverse health disorders that affect their kidneys, heart and vision. Due to these conditions, diabetes patients have traditionally checked blood glucose levels through Self-Monitoring of Blood Glucose (SMBG) techniques, like pricking their fingers multiple times per day. Such techniques involve a number of drawbacks that can be solved by using a device called Continuous Glucose Monitor (CGM), which can measure blood glucose levels continuously throughout the day without having to prick the patient when carrying out every measurement. This article details the design and implementation of a system that enhances commercial CGMs by adding Internet of Things (IoT) capabilities to them that allow for monitoring patients remotely and, thus, warning them about potentially dangerous situations. The proposed system makes use of smartphones to collect blood glucose values from CGMs and then sends them either to a remote cloud or to distributed fog computing nodes. Moreover, in order to exchange reliable, trustworthy and cybersecure data with medical scientists, doctors and caretakers, the system includes the deployment of a decentralized storage system that receives, processes and stores the collected data. Furthermore, in order to motivate users to add new data to the system, an incentive system based on a digital cryptocurrency named GlucoCoin was devised. Such a system makes use of a blockchain that is able to execute smart contracts in order to automate CGM sensor purchases or to reward the users that contribute to the system by providing their own data. Thanks to all the previously mentioned technologies, the proposed system enables patient data crowdsourcing and the development of novel mobile health (mHealth) applications for diagnosing, monitoring, studying and taking public health actions that can help to advance in the control of the disease and raise global awareness on the increasing prevalence of diabetes.Xunta de Galicia; ED431G/01Xunta de Galicia; ED431C 2016-045Agencia Estatal de Investigación de España; TEC2016-75067-C4-1-

Towards an Autonomous Industry 4.0 Warehouse: A UAV and Blockchain-Based System for Inventory and Traceability Applications in Big Data-Driven Supply Chain Management

[Abstract] Industry 4.0 has paved the way for a world where smart factories will automate and upgrade many processes through the use of some of the latest emerging technologies. One of such technologies is Unmanned Aerial Vehicles (UAVs), which have evolved a great deal in the last years in terms of technology (e.g., control units, sensors, UAV frames) and have significantly reduced their cost. UAVs can help industry in automatable and tedious tasks, like the ones performed on a regular basis for determining the inventory and for preserving item traceability. In such tasks, especially when it comes from untrusted third parties, it is essential to determine whether the collected information is valid or true. Likewise, ensuring data trustworthiness is a key issue in order to leverage Big Data analytics to supply chain efficiency and effectiveness. In such a case, blockchain, another Industry 4.0 technology that has become very popular in other fields like finance, has the potential to provide a higher level of transparency, security, trust and efficiency in the supply chain and enable the use of smart contracts. Thus, in this paper, we present the design and evaluation of a UAV-based system aimed at automating inventory tasks and keeping the traceability of industrial items attached to Radio-Frequency IDentification (RFID) tags. To confront current shortcomings, such a system is developed under a versatile, modular and scalable architecture aimed to reinforce cyber security and decentralization while fostering external audits and big data analytics. Therefore, the system uses a blockchain and a distributed ledger to store certain inventory data collected by UAVs, validate them, ensure their trustworthiness and make them available to the interested parties. In order to show the performance of the proposed system, different tests were performed in a real industrial warehouse, concluding that the system is able to obtain the inventory data really fast in comparison to traditional manual tasks, while being also able to estimate the position of the items when hovering over them thanks to their tag’s signal strength. In addition, the performance of the proposed blockchain-based architecture was evaluated in different scenarios.Xunta de Galicia; ED431C 2016-045Xunta de Galicia; ED431G/01Agencia Estatal de Investigación de España; TEC2016-75067-C4-1-

A peptidome-based phylogeny pipeline reveals differential peptides at the strain level within Bifidobacterium animalis subsp. lactis

Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.fm.2016.06.015.Bifidobacteria are gut commensal microorganisms belonging to the Actinobacteria group. Some specific strains of Bifidobacterium animalis subsp. lactis are used in functional foods as they are able to exert health-promoting effects in the human host. Due to the limited genetic variability within this subspecies, it is sometimes difficult for a manufacturer to properly track its strain once included in dairy products or functional foods. In this paper, we present a peptidome-based analysis in which the proteomes of a set of B. animalis subsp. lactis strains were digested in silico with human gut endopeptidases. The molecular masses were compared along all the strains to detect strain-specific peptides. These peptides may be interesting towards the development of methodologies for strain identification in the final product.This research was funded by Grant AGL2013-44039-R from the Spanish “Plan Estatal de IþDþI”, and by Grant EM2014/046 from the “Plan Galego de investigaci on, innovaci on e crecemento 2011e2015”. Borja S anchez was recipient of a Ram on y Cajal postdoctoral contract from the Spanish Ministry of Economy and Competitiveness (RYC-2012-10052). This work was also partially funded by the [14VI05] Contract- Programme from the Unixikversity of Vigo and the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273). The research leading to these results has also received funding from the European Union’s Seventh Framework Programme FP7/REGPOT-2012-2013.1 under grant agreement no 316265, BIOCAPS. This document reflects only the author’s views and the European Union is not liable for any use that may be made of the information contained herein

Tackling probiotic and gut microbiota functionality through proteomics

Abstract Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Many strains exert their beneficial effects after transiently colonizing the human gut, where they interact with the rest of the intestinal microorganisms and with the host mucosa. Indeed the human gut harbours a huge number of microorganisms also known as gut microbiota. Imbalances in the relative abundances of the individual components of the gut microbiota may determine the health status of the host and alterations in specific groups have been related to different diseases and metabolic disorders. Proteomics provide a set of high-throughput methodologies for protein identification that are extremely useful for studying probiotic functionality and helping in the assessment of specific health-promoting activities, such as their immunomodulatory activity, the intestinal colonization processes, and the crosstalk mechanisms with the host. Furthermore, proteomics have been used to identify markers of technological performance and stress adaptation, which helps to predict traits such as behaviour into food matrices and ability to survive passage through the gastrointestinal tract. The aim of this review is to compile studies in which proteomics have been used to assess probiotic functionality and to identify molecular players supporting their mechanisms of action. Significance Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Molecular basis underlying the functional properties of probiotic bacteria responsible for the health promoting effects have been in the background for many years. Breakthrough of omics technologies in the probiotic and microbiota fields has had a very relevant impact in the elucidation of probiotic mechanisms and in the procedures to select these microorganisms, based on solid scientific evidence. It is unquestionable that, in the near future, the evolution of proteomic techniques will play a pivotal role in the generation of knowledge about the functions of probiotics and gut commensals, still a pending issue in the field of intestinal microbiomics.Research in our lab is funded by Grants AGL2013-44039-R and AGL2013-44761-P from the Spanish “Plan Estatal de I + D + I”. Part of the authors is also partially funded by the [15VI013] Contract-Programme from the University of Vigo and the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273). Lorena Ruiz has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/under REA grant agreement n° 624773. Borja Sánchez was recipient of a Ramón y Cajal postdoctoral contract from the Spanish Ministry of Economy and Competitiveness