Lasso Estimation of an Interval-Valued Multiple Regression Model

A multiple interval-valued linear regression model considering all the cross-relationships between the mids and spreads of the intervals has been introduced recently. A least-squares estimation of the regression parameters has been carried out by transforming a quadratic optimization problem with inequality constraints into a linear complementary problem and using Lemke's algorithm to solve it. Due to the irrelevance of certain cross-relationships, an alternative estimation process, the LASSO (Least Absolut Shrinkage and Selection Operator), is developed. A comparative study showing the differences between the proposed estimators is provided

Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis

Peer reviewedPublisher PD

CRIRES-VLT high-resolution spectro-astrometry as a tool in the search of small structures at the cores of Planetary Nebulae

The onset of the asymmetry in planetary nebulae (PNe) occurs during the short transition between the end of the asymptotic giant branch (AGB) phase and the beginning of the PN phase. Sources in this transition phase are compact and emit intensely in infrared wavelengths, making high spatial resolution observations in the infrared mandatory to investigate the shaping process of PNe. Interferometric VLTI IR observations have revealed compelling evidence of disks at the cores of PNe, but the limited sensitivity, strong observational constraints, and limited spatial coverage place severe limits on the universal use of this technique. Inspired by the successful detection of proto-planetary disks using spectro-astrometric observations, we apply here for the first time this technique to search for sub-arcsecond structures in PNe. Our exploratory study using CRIRES (CRyogenic high-resolution Infra-Red Echelle Spectrograph) commissioning data of the proto-PN IRAS 17516-2525 and the young PN SwSt 1 has revealed small-sized structures after the spectro-astrometric analysis of the two sources. In IRAS 17516-2525, the spectro-astrometric signal has a size of only 12 mas, as detected in the Brackett-gamma line, whereas the structures found in SwSt 1 have sizes of 230 mas in the [Fe III] line and 130 mas in the Brackett-gamma line. The spectroscopic observations required to perform spectro-astrometry of sources in the transition towards the PN phase are less time consuming and much more sensitive than VLTI IR observations. The results presented here open a new window in the search of the small-sized collimating agents that shape the complex morphologies of extremely axisymmetric PNe.Comment: 6 pages, 4 figure

VISIR-VLT Images of the Water Maser Emitting Planetary Nebula K 3-35

K3-35 is an extremely young bipolar planetary nebula that contains a precessing bipolar jet and a small (radius 80 AU) water maser equatorial ring. We have obtained VISIR- VLT images of K 3-35 in the PAH1 ({\lambda}=8.6 {\mu}m), [S iv] ({\lambda}=10.6 {\mu}m), and SiC ({\lambda}=11.85 {\mu}m) filters to analize the mid-IR morphology and the temperature structure of its dust emission. The images show the innermost nebular regions undetected at optical wavelegths and the precessing bipolar jets. The temperature map shows variations in the temperature in the equatorial zone and in regions associated to its jets.Comment: 2 pages, 2 figures, 283 IAU Symp. Planetary Nebulae an Eye to the Futur

The effects of GABAergic polarity changes on episodic neural network activity in developing neural systems

This is the final version of the article. Available from the publisher via the DOI in this record.Early in development, neural systems have primarily excitatory coupling, where even GABAergic synapses are excitatory. Many of these systems exhibit spontaneous episodes of activity that have been characterized through both experimental and computational studies. As development progress the neural system goes through many changes, including synaptic remodeling, intrinsic plasticity in the ion channel expression, and a transformation of GABAergic synapses from excitatory to inhibitory. What effect each of these, and other, changes have on the network behavior is hard to know from experimental studies since they all happen in parallel. One advantage of a computational approach is that one has the ability to study developmental changes in isolation. Here, we examine the effects of GABAergic synapse polarity change on the spontaneous activity of both a mean field and a neural network model that has both glutamatergic and GABAergic coupling, representative of a developing neural network. We find some intuitive behavioral changes as the GABAergic neurons go from excitatory to inhibitory, shared by both models, such as a decrease in the duration of episodes. We also find some paradoxical changes in the activity that are only present in the neural network model. In particular, we find that during early development the inter-episode durations become longer on average, while later in development they become shorter. In addressing this unexpected finding, we uncover a priming effect that is particularly important for a small subset of neurons, called the "intermediate neurons." We characterize these neurons and demonstrate why they are crucial to episode initiation, and why the paradoxical behavioral change result from priming of these neurons. The study illustrates how even arguably the simplest of developmental changes that occurs in neural systems can present non-intuitive behaviors. It also makes predictions about neural network behavioral changes that occur during development that may be observable even in actual neural systems where these changes are convoluted with changes in synaptic connectivity and intrinsic neural plasticity.WB was supported by a scholarship (Process #202320/2015-4) from the Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico—CNPq). RB was partially supported by National Science Foundation gran

VISIR-VLT high resolution study of the extended emission of four obscured post-AGB candidates

The onset of the asymmetry of planetary nebulae (PNe) is expected to occur during the late Asymptotic Giant Branch (AGB) and early post-AGB phases of low- and intermediate-mass stars. Among all post-AGB objects, the most heavily obscured ones might have escaped the selection criteria of previous studies detecting extreme axysimmetric structures in young PNe. Since the most heavily obscured post-AGB sources can be expected to descend from the most massive PN progenitors, these should exhibit clear asymmetric morphologies. We have obtained VISIR-VLT mid-IR images of four heavily obscured post-AGB objects barely resolved in previous Spitzer IRAC observations to analyze their morphology and physical conditions across the mid-IR. The VISIR-VLT images have been deconvolved, flux calibrated, and used to construct RGB composite pictures as well as color and optical depth maps that allow us to study the morphology and physical properties of the extended emission of these sources. We have detected extended emission from the four objects in our sample and resolved it into several structural components that are greatly enhanced in the temperature and optical depth maps. They reveal the presence of asymmetry in three young PNe (IRAS 15534-5422, IRAS 17009-4154, and IRAS 18454+0001), where the asymmetries can be associated with dusty torii and slightly bipolar outflows. The fourth source (IRAS 18229-1127), a possible post-AGB star, is better described as a rhomboidal detached shell. The heavily obscured sources in our sample do not show extreme axisymmetric morphologies. This is at odds with the expectation of highly asymmetrical morphologies in post-AGB sources descending from massive PN progenitors. The sources presented in this paper may be sampling critical early phases in the evolution of massive PN progenitors, before extreme asymmetries develop.Comment: 9 pages, 4 figure

Chiral properties of hematite ({\alpha}-Fe2O3) inferred from resonant Bragg diffraction using circularly polarized x-rays

Chiral properties of the two phases - collinear motif (below Morin transition temperature, TM=250 K) and canted motif (above TM) - of magnetically ordered hematite ({\alpha}-Fe2O3) have been identified in single crystal resonant x-ray Bragg diffraction, using circular polarized incident x-rays tuned near the iron K-edge. Magneto-electric multipoles, including an anapole, fully characterize the high-temperature canted phase, whereas the low-temperature collinear phase supports both parity-odd and parity-even multipoles that are time-odd. Orbital angular momentum accompanies the collinear motif, while it is conspicuously absent with the canted motif. Intensities have been successfully confronted with analytic expressions derived from an atomic model fully compliant with chemical and magnetic structures. Values of Fe atomic multipoles previously derived from independent experimental data, are shown to be completely trustworthy