2,172 research outputs found
The proteomic approach to research the pathogenesis, diagnostic, prognostic and new therapeutic targets in osteoarthritis
Comunicaciones a congreso
R&D expenditure in the EU: convergence or divergence?
This article examines the convergence of the R&D expenditure in
the EU28 for 2004–2015. We initially run a sigma convergence
analysis and the results show convergence in the total expenditure,
due to the behaviour of the business and higher education
sectors, despite government sector divergence. However, noticeable
differences between the EU15 and 13 EU countries are
apparent. The business enterprise sector is the main driver of
EU15 R&D convergence, whereas for the EU13 this role is played
by the government expenditure. In addition, the economic crisis
has impacted differently on both groups. The club convergence
approach allows us to explore these insights through individualized
analysis and clusterization. Results for the EU28 show two
clubs for the total expenditure, but the analysis of its components
reveals a larger grouping. Our results evidence the necessity of
revising the EU R&D policies towards greater coordination and
resources, and the implementation of new instruments, due to
the impact of this expenditure on growth, development and
integration
Bubble bursting jets are driven by the purely inertial collapse of gas cavities
The analysis of numerical simulations describing the collapse of capillary
cavities reveals that the jets originated from the bursting of bubbles are
driven by the condition that the dimensionless liquid flow rate per unit length
directed towards the axis of symmetry, , remains nearly constant in
time. This observation, which is justified in physical terms because liquid
inertia prevents appreciable changes in during the short time scale
characterizing the jet ejection process, together with the fact that bubble
bursting jets are produced from the bottom of a conical cavity, justify the
purely inertial scalings for the jet width and velocity found here,
and ,
with indicating the dimensionless time after the jet is ejected, a
result which notably differs from the common belief that the jet width and
velocity follow the inertio-capillary scaling and
. Our description reproduces the time evolution of
the jet width and velocity for over three decades in time, obtaining good
agreement with numerical simulations from the instant of jet inception until
the jet width is comparable to that of the initial bubble.Comment: 15 pages, 10 figures. Figures are revised and properly referenced
(v100323
Mitochondrial DNA in Osteoarthritis Disease
[Abstract]
Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal joint function characterized by cartilage degradation, bone remodeling, osteophyte formation, and joint inflammation [1]. Recent insights into the epidemiology and impact of OA on patients have clearly established that OA is a severe disease of the whole joint as an organ, with large unmet medical needs.
OA has a complex etiology that comprises the combination of multiple factors, including gender, age, occupation, trauma, body mass index, and genetics. Approximately, between 30 and 65% of the risk of OA is genetically determined [2] with evidence accumulated from different genome-wide association studies (GWAS) [3]. Most of these studies focused on nuclear genetic variants; however, over the last decade, evidence has accumulated for an association between specific mitochondrial DNA (mtDNA) genetic variants, called haplogroups, and different OA-related features, including prevalence, progression, and incidence [4].Instituto de Salud Carlos III; CIBERCB06/01/0040Instituto de Salud Carlos III; RETIC-RIER-RD16/0012/0002Instituto de Salud Carlos III; PRB2-ISCIII-PT17/0019/0014Instituto de Salud Carlos III; PI14/01254Instituto de Salud Carlos III; PI16/02124Instituto de Salud Carlos III; PI17/0021
Results on Argentine (Argentina spp.), Bluemouth (Helicolenus dactylopterus), Greater forkbeard (Phycis blennoides) and Spanish ling (Molva macrophthalma) from 2011 Porcupine Bank (NE Atlantic) survey
This paper presents the results on four of the mostimportant deep fish
species of the last Porcupine Spanish survey carried in 2011, and
updates the document presented in previous years with the information
on the first ten years (2001-2010) of the PorcupineSpanish surveys. The
document presents total abundances in weight, length frequencies and
geographical distributions for Argentina spp. (mostly A. silus, results on
A. silus/A. sphiraena distribution in last surveys are provided),
bluemouth, greater fork-beard and Spanish ling. Also information on
records of Blue ling during the survey series is shown.Versión de edito
Results on Argentine (Argentina spp.), Bluemouth (Helicolenus dactylopterus), Greater forkbeard (Phycis blennoides) and Spanish ling (Molva macrophthalma) from 2010 Porcupine Bank (NE Atlantic) survey
This paper presents the results on four of the mostimportant deep fish
species in the Porcupine bottom trawl survey organized by the Spanish
Institute of Oceanography in 2010, and updates the documents presented
in previous years with the information on the first nine years (2001-2009) of the Porcupine Spanish surveys. The document presents total
abundances in weight, length frequencies and geographical distributions
for Argentina spp. (mostly A. silus, results on A. silus/A. sphiraena
distribution in last survey is presented), bluemouth, greater fork-beard
and Spanish ling and information on records of blue ling during the
survey series.Versión de edito
Results on Argentine (Argentina spp.), Bluemouth (Helicolenus dactylopterus), Greater forkbeard (Phycis blennoides) and Spanish ling (Molva macrophthalma) from 2008 Porcupine Bank (NE Atlantic) survey
This paper presents the results on four of the most important deep fish
species of the last Porcupine Spanish survey carried in 2008, and
updates the document presented in the previous year with the
information on the first seven years (2001-2007) of the Porcupine
Spanish surveys. The document presents total abundances in weight,
length frequencies and geographical distributions for Argentina spp.
(mostly A. silus), bluemouth, greater fork-beard and Spanish ling.Versión de edito
Collaborative Multiobjective Evolutionary Algorithms in search of better Pareto Fronts. An application to trading systems
Technical indicators use graphic representations of data sets by applying
various mathematical formulas to financial time series of prices. These
formulas comprise a set of rules and parameters whose values are not
necessarily known and depend on many factors: the market in which it operates,
the size of the time window, and others. This paper focuses on the real-time
optimization of the parameters applied for analyzing time series of data. In
particular, we optimize the parameters of technical and financial indicators
and propose other applications, such as glucose time series. We propose the
combination of several Multi-objective Evolutionary Algorithms (MOEAs). Unlike
other approaches, this paper applies a set of different MOEAs, collaborating to
construct a global Pareto Set of solutions. Solutions for financial problems
seek high returns with minimal risk. The optimization process is continuous and
occurs at the same frequency as the investment time interval. This technique
permits the application of non-dominated solutions obtained with different
MOEAs simultaneously. Experimental results show that this technique increases
the returns of the commonly used Buy \& Hold strategy and other multi-objective
strategies, even for daily operations
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