Suppressed antinodal coherence with a single d-wave superconducting gap leads to two energy scales in underdoped cuprates

Conventional superconductors are characterized by a single energy scale, the superconducting gap, which is proportional to the critical temperature Tc . In hole-doped high-Tc copper oxide superconductors, previous experiments have established the existence of two distinct energy scales for doping levels below the optimal one. The origin and significance of these two scales are largely unexplained, although they have often been viewed as evidence for two gaps, possibly of distinct physical origins. By measuring the temperature dependence of the electronic Raman response of Bi2Sr2CaCu2O8+d (Bi-2212) and HgBa2CuO4+d (Hg-1201) crystals with different doping levels, we establish that these two scales are associated with coherent excitations of the superconducting state which disappears at Tc. Using a simple model, we show that these two scales do not require the existence of two gaps. Rather, a single d-wave superconducting gap with a loss of Bogoliubov quasiparticle spectral weight in the antinodal region is shown to reconcile spectroscopic and transport measurements.Comment: 3 figure

assessment of disease burden in the phase iii celestial trial of cabozantinib c versus placebo p in advanced hepatocellular carcinoma hcc

n/

Nmrk2 gene is upregulated in dilated cardiomyopathy and required for cardiac function and nad levels during aging

Dilated cardiomyopathy (DCM) is a disease of multifactorial etiologies, the risk of which is increased by male sex and age. There are few therapeutic options for patients with DCM who would benefit from identification of common targetable pathways. We used bioinformatics to identify the Nmrk2 gene involved in nicotinamide adenine dinucleotde (NAD) coenzyme biosynthesis as activated in different mouse models and in hearts of human patients with DCM while the Nampt gene controlling a parallel pathway is repressed. A short NMRK2 protein isoform is also known as muscle integrin binding protein (MIBP) binding the α7β1 integrin complex. We investigated the cardiac phenotype of Nmrk2-KO mice to establish its role in cardiac remodeling and function. Young Nmrk2-KO mice developed an eccentric type of cardiac hypertrophy in response to pressure overload rather than the concentric hypertrophy observed in controls. Nmrk2-KO mice developed a progressive DCM-like phenotype with aging, associating eccentric remodeling of the left ventricle and a decline in ejection fraction and showed a reduction in myocardial NAD levels at 24 months. In agreement with involvement of NMRK2 in integrin signaling, we observed a defect in laminin deposition in the basal lamina of cardiomyocytes leading to increased fibrosis at middle age. The α7 integrin was repressed at both transcript and protein level at 24 months. Nmrk2 gene is required to preserve cardiac structure and function, and becomes an important component of the NAD biosynthetic pathways during aging. Molecular characterization of compounds modulating this pathway may have therapeutic potential

Quantitative Raman measurements of the evolution of the Cooper-pairs density with doping in Bi2Sr2CaCu2O8+d superconductors

We report Raman measurements on Bi2Sr2CaCu2O8+d single crystals which allow us to quantitavely evaluate the doping dependence of the density of Cooper pairs in the superconducting state. We show that the drastic loss of Cooper pairs in the antinodal region as the doping level is reduced, is concomitant with a deep alteration of the quasiparticles dynamic above Tc and consistent with a pseudogap which competes with superconductivity. Our data also reveal that the overall density of Cooper pairs evolves with doping, distinctly from the superfluid density above the doping level pc=0.2.Comment: 3 figure

Screened and Unscreened Phases in Sedimenting Suspensions

A coarse-grained stochastic hydrodynamical description of velocity and concentration fluctuations in steadily sedimenting suspensions is constructed, and analyzed using self-consistent and renormalization group methods. We find that there exists a dynamical, non-equilibrium phase transition from an "unscreened" phase in which we recover the Caflisch-Luke (R.E. Caflisch and J.H.C. Luke, Phys. Fluids 28, 759 (1985)) divergence of the velocity variance to a "screened" phase where the velocity fluctuations have a finite correlation length growing as $\phi^{-1/3}$ where $\phi$ is the particle volume fraction, in agreement with Segr\`e et. al. (Phys. Rev. Lett. 79, 2574 (1997)) and the velocity variance is independent of system size. Detailed predictions are made for the correlation function in both phases and at the transition.Comment: 4 pages, revtex 1 figur

Corrigendum to "Decoupling the effects of clear atmosphere and clouds to simplify calculations of the broadband solar irradiance at ground level" published in Geosci. Model Dev., 7, 1661–1669, 2014

No abstract available

Full-scale validation of bio-recycled asphalt mixtures for road pavements

Recycling of asphalt has become a well-established practice in many countries, however the road pavement industry remains a bulk consumer of extracted raw materials. Novel solutions that find root in circular economy concepts and life‐cycle approaches are needed in order to enable optimisation of infrastructure resource efficiency, starting from the design stage and spanning the whole value chain in the construction sector. Itis within this framework that the present study presents a full-scale validation of asphalt mixtures specifically designed to ensure durability of flexible road pavements and at the same time enabling the reuse of reclaimed asphalt pavement (RAP) through the incorporation of bio-materials as recycling agent. These bio-recycled asphalt mixtures have been first designed in laboratory and subsequently validated in a real scale experiment conducted at the accelerated pavement testing facilities at IFSTTAR. Four pavement sections were evaluated: three test sections with innovative bio-materials, and a reference section with a conventional, high modulus asphalt mix (EME2). Two tests were realized: a rutting test and a fatigue test and for each of them the evolution of bio-recycled asphalt mixtures properties as well as the pavement deteriorations were recorded and studied. Evolution of the bio-asphalt mixtures was monitored for a 5 months period after paving by a bespoke nondestructive micro-coring, extracting and recovering methodology developed at the Western Research Institute (WRI). The structural health of the pavement sections was monitored through periodic falling weight deflectometer (FWD) as well as with strain gages and temperature sensors. As a result the three tailored bio-asphalt mixtures performed similarly or better than the control mixture, both in terms of property evolutions and durability

The genome and transcriptome of Trichormus sp NMC-1: insights into adaptation to extreme environments on the Qinghai-Tibet Plateau

The Qinghai-Tibet Plateau (QTP) has the highest biodiversity for an extreme environment worldwide, and provides an ideal natural laboratory to study adaptive evolution. In this study, we generated a draft genome sequence of cyanobacteria Trichormus sp. NMC-1 in the QTP and performed whole transcriptome sequencing under low temperature to investigate the genetic mechanism by which T. sp. NMC-1 adapted to the specific environment. Its genome sequence was 5.9 Mb with a G+C content of 39.2% and encompassed a total of 5362 CDS. A phylogenomic tree indicated that this strain belongs to the Trichormus and Anabaena cluster. Genome comparison between T. sp. NMC-1 and six relatives showed that functionally unknown genes occupied a much higher proportion (28.12%) of the T. sp. NMC-1 genome. In addition, functions of specific, significant positively selected, expanded orthogroups, and differentially expressed genes involved in signal transduction, cell wall/membrane biogenesis, secondary metabolite biosynthesis, and energy production and conversion were analyzed to elucidate specific adaptation traits. Further analyses showed that the CheY-like genes, extracellular polysaccharide and mycosporine-like amino acids might play major roles in adaptation to harsh environments. Our findings indicate that sophisticated genetic mechanisms are involved in cyanobacterial adaptation to the extreme environment of the QTP