The politics of scale through Rancière

From SAGE Publishing via Jisc Publications RouterHistory: epub 2020-08-10Publication status: PublishedThis paper argues that human geography’s scale debate has arrived at somewhat of an impasse surrounding scale’s relative position to ontology. Divides are most evident between those that see scales as ‘already existing’ and those considering this as a form of ‘ontological reification’ that stifles our understanding of politics. I suggest that reading the ‘politics of scale’ through Jacques Rancière’s political thinking, and in particular his aesthetic approach to the problem of ontological reductionism, can offer one way forward. It enables geographers to take existing ‘common-sense’ ideas around scale seriously whilst also being sensitive to emergent politics

Intervention : Engaging post-foundational political theory requires an ‘enmeshed’ approach

This intervention argues for renewed engagements with post-foundational political theory (PFPT) within political geography. We feel that post-foundational political geography may be on the cusp of becoming consolidated as a distinct and expansive approach to political geographic scholarship, but we argue that reductionist and binary caricatures of its central distinction between ‘politics’ and ‘the political’ must be avoided for it to reach its full potential. To this end, we suggest that ‘politics’ and ‘the political’ need to be considered as more ‘enmeshed’ than they have often been represented. We write as four political geographers and will, each in our own ways, highlight how an ‘enmeshed’ approach to PFPT can better translate its conceptual interventions into political geographic research whilst facilitating productive encounters with the broader worlds of critical geographic inquiry.publishedVersionPeer reviewe

Asthma exacerbation and steroid burden in Australian primary care

Peer reviewedPostprin

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant