334 research outputs found
Analysis and quantification of the benefits of interconnected distribution system operation
In the UK, the Capacity to Customers (C2C) project is underway to determine the potential beneļ¬ts of increased interconnection in distribution systems, combined with demand side response technology. Managed contracts with customers, i.e., the agreement that certain loads are interruptible following system faults, allows distribution circuits to be loaded beyond the limits presently required for security of supply. This potentially permits load growth but avoids the cost and environmental impact of conventional network reinforcement. This paper provides the results of electrical system modelling to quantify the beneļ¬ts of the C2C operation, using actual circuit data and typical load distributions. Based upon simulations of these circuits, it is shown that increased interconnection generally leads to minor improvements in electrical losses and system voltage. By connecting managed (i.e., interruptible) loads, circuits typically can be loaded signiļ¬cantly further than the present practice in the UKāan average increase of 66% for radial operation and 74% for interconnected systems
Welch Informationist Collaboration with the Johns Hopkins Medicine Department of Radiology
With the announcement of the NLM Administrative Supplement Grant, the informationists at the Welch Medical Library found an interested and enthusiastic Principal Investigator (PI) in the Department of Radiology at The Johns Hopkins School of Medicine. Although the PI had not used the services of a Welch informationist before, he was eager to collaborate with an informationist on the grant āDose-Response in Radionuclide Therapy,ā (Parent Grant Number: 5R01CA116477-07) and had self-identified the need for āa literature review by expertsā to fulfill his funded work.
Targeted radionuclide therapy is an emerging modality for cancer therapy that involves the delivery of radioactive atoms using carriers that preferentially bind to tumor cells. Such treatment is best implemented with patient-specific dosimetry calculations. This mutually beneficial partnership brings the specialized skill set, knowledge base and expertise of an informationist to the biomedical research team to assist in accomplishing the broader work of improving RPT delivery in metastatic cancer patients.
The informationist will carry out multiple tasks to produce an effective and efficient workflow that facilitates the dissemination of the information to a globally dispersed research team. This collaboration will be evaluated both quantitatively and qualitatively, and the important role of the informationist in the success of this project will demonstrate the value of including an informationist in the research team. This demonstrated value will assist Welch Library in continuing to promote the embedded informationist program to other interested researchers throughout the institution
Translating proprietary protection setting data into standardized IEC 61850 format for protection setting validation
For smart grid development, one of the key expectations is that the data should be accessible to and readily interpreted by different applications. Presently, protection settings are represented using proprietary parameters and stored in various file formats. This makes it very difficult for computer applications to manipulate such data directly. This paper introduces a process that translates the proprietary protection setting data into IEC 61850 standardised format and saves the data as System Configuration description Language (SCL) files. A code generation process that allows rapid implementation of the translation process is proposed. Among various applications, the paper demonstrates how such a translation process and generated SCL files can facilitate the development of an intelligent system for protection setting error detection and validation
Standardization of power system protection settings using IEC 61850 for improved interoperability
One of the potential benefits of smart grid development is that data becomes more open and available for use by multiple applications. Many existing protection relays use proprietary formats for storing protection settings. This paper proposes to apply the IEC 61850 data model and System Configuration description Language (SCL), which are formally defined, to represent protection settings. Protection setting files in proprietary formats are parsed using rule-based reasoning, mapped to the IEC 61850 data model, and exported as SCL files. An important application of using SCL-based protection setting files is to achieve protection setting interoperability, which could bring multiple compelling benefits, such as significantly streamlining the IED configuration process and releasing utilities from being ālocked inā to one particular vendor. For this purpose, this paper proposes a uniform configuration process for future IEDs. The challenges involved in the implementation of the proposed approach are discussed and possible solutions are presented
Prognostic modelling utilizing a high fidelity pressurized water reactor simulator
Within power generation, aging assets and an emphasis on more efficient operation of power systems and improved maintenance decision methods has led to a growing focus on asset prognostics. The main challenge facing the implementation of successful asset prognostics in power generation is the lack of available run-to-failure data. This paper proposes to overcome this issue by use of full-scope high-fidelity simulators to generate the run-to-failure data required. From this simulated failure data a similarity-based prognostic approach is developed for estimating the remaining useful life of a valve asset. Case study data is generated by initializing prebuilt industrial failure models within a 970 MW pressurized water reactor simulation. Such full-scope high-fidelity simulators are mainly operated for training purposes, allowing personnel to gain experience of standard operation as well as failures within a safe, simulated operating environment. This paper repurposes such a high-fidelity simulator to generate the type of data and affects that would be produced in the event of a fault. The fault scenario is then run multiple times to generate a library of failure events. This library of events was then split into training and test batches for building the prognostic model. Results are presented and conclusions drawn about the success of the technique and the use of high-fidelity simulators in this manner
Emotional Reactivity and Regulation in Preschool-Age Children Who Do and Do Not Stutter: Evidence From Autonomic Nervous System Measures
Purpose: This experimental cross-sectional research study examined the emotional reactivity and emotion regulation in preschool-age children who do (CWS) and do not stutter (CWNS) by assessing their psychophysiological response during rest and while viewing pictures from the International Affective Picture System (Lang et al., 2008). Method: Participants were 18 CWS (16 boys and two girls; mean age 4 years, 5 months) and 18 age- and gender-matched CWNS. Participantsā psychophysiological responses were measured during two baselines and two picture viewing conditions. Skin conductance level (SCL) and heart rate were measured to assess emotional reactivity. Respiratory sinus arrhythmia (RSA) was measured to assess emotional regulation. Participantsā shyness and executive function were assessed via parent report and considered for their effects on participantsā psychophysiological responses. Results: First, CWNS and CWS did not differ in their initial baseline SCL, heart rate, or RSA, but all participants had higher SCL and lower RSA in the second baseline, subsequent to the ļ¬rst challenge condition, compared to the ļ¬rst baseline. Second, during the challenge conditions, CWS did not differ from CWNS in their SCL, but showed a signiļ¬cantly higher heart rate than CWNS. Third, CWS exhibited a signiļ¬cantly lower RSA during the challenge conditions compared to CWNS. Lastly, the temperamental quality of shyness was associated with preschool-age childrenās SCL, such that participants who were rated higher in shyness had a higher SCL during the challenge conditions. Participantsā executive function had a marginally signiļ¬cant effect on the RSA, such that the participants who had higher executive function composite scores exhibited lower RSA during the challenge conditions. Conclusions: Our ļ¬ndings suggest that CWS and CWNS did not differ in their emotional reactivity and emotional regulation abilities at rest. During challenge conditions, however, CWS tended to be more emotionally reactive, as indicated by a higher heart rate, and also employed more emotional regulation, indexed by a greater decrease in RSA, compared to CWNS. Preschool-age childrenās behavior is largely dominated by reactivity, but there is the emergence of regulation, which can help children adjust to various contextual demands. For CWS who are more emotionally reactive, regulatory skills may be particularly critical to their prognosis and treatment
Automatically detecting and correcting errors in power quality monitoring data
Dependable power quality (PQ) monitoring is crucial for evaluating the impact of smart grid developments. Monitoring schemes may need to cover a relatively large network area, yet must be conducted in a cost-effective manner. Real-time communications may not be available to observe the status of a monitoring scheme or to provide time synchronization, and therefore undetected errors may be present in the data collected. This paper describes a process for automatically detecting and correcting errors in PQ monitoring data, which has been applied in an actual smart grid project. It is demonstrated how to: unambiguously recover from various device installation errors; enforce time synchronization between multiple monitoring devices and other events by correlation of measured frequency trends; and efficiently visualize PQ data without causing visual distortion, even when some data values are missing. This process is designed to be applied retrospectively to maximize the useful data obtained from a network PQ monitoring scheme, before quantitative analysis is performed. This work therefore ensures that insights gained from the analysis of the data - and subsequent network operation or planning decisions - are also valid. A case study of a UK smart grid project, involving wide-scale distribution system PQ monitoring, demonstrates the effectiveness of these contributions. All source code used for the paper is available for reuse
Direct Reaction ā One Step Route to Synthesize Lanthanoid-iodide Formamidinates**
This paper describes a novel and simple method ā direct reaction of lanthanoid metals with equimolar amounts of iodine and a formamidine under ultrasonication as an effective, metal-based route to lanthanoid(III) diiodide formamidinates, namely I. N,Nā²-Bis(2,6-diisopropylphenyl)formamidinatodiiodidolanthanoid(III) complexes [Ln(DippForm)I2(thf)3] (Ln=La, 1, Ce, 2, Tb, 3, Ho, 4, Er, 5, Tm, 6); II. N,Nā²-Bis(2,6-diethylphenyl)formamidinatodiiodidolanthanoid(III) complexes [Ln(EtForm)I2(thf)3] (Ln=Ce, 7, Nd, 8, Gd, 9, Tb, 10, Dy, 11, Ho, 12, Er, 13, Lu, 14). III. N,Nā²-bis(2,6-dimethylphenyl)formamidinatodiiodidolanthanoid(III) complexes [Ln(XylForm)I2(thf)3] (Ln=Ce, 15, Nd, 16, Gd, 17, Tm, 18, Lu 19); IV. ,Nā²-bis(phenyl)formamidinatodiiodidolanthanoid complexes [Ln(PhForm)I2(thf)3] (Ln=Nd, 20, Gd, 21, Er, 22). Compound [Ce(XylForm)2I(thf)2] (23) was also synthesized by the same method except the ratio of I2 to XylFormH was 1 : 4. Divalent N,Nā²-bis(2,6-diisopropylphenyl)formamidinato-iodido-lanthanoid(II) complexes [Eu(DippForm)I(thf)4] ā
thf (24), [Yb(DippForm)I(thf)3] ā
2DippFormH (25), [Sm(DippForm)I(thf)4] ā
thf (26) have also been synthesized by direct reactions of the free metals, iodine and DippFormH. Interestingly, [Sm(DippForm)I2(thf)3] (27) was obtained by the oxidation of [Sm(DippForm)I(thf)4] ā
thf (26) on exposure to air. N,Nā²-Bis(2,6-dimethylphenyl)formamidinatoiodidosamarium(II) [Sm(XylForm)I(thf)3]n (28) was also prepared by direct reaction of Sm, iodine and XylFormH (mole ratio of I2: XylFormH=1 : 2). All products have been identified by X-ray crystallography and all the trivalent complexes [Ln(Form)nI3-n] (n=1 or 2) are stable to rearrangement
Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect
Nipah virus (NiV) is a highly pathogenic zoonotic virus with a broad species tropism,
originating in pteropid bats. Human outbreaks of NiV disease occur almost annually, often with
high case-fatality rates. The specific events that lead to pathogenesis are not well defined, but the
disease has both respiratory and encephalitic components, with relapsing encephalitis occurring in
some cases more than a year after initial infection. Several cell types are targets of NiV, dictated by
the expression of the ephrin-B2/3 ligand on the cellās outer membrane, which interact with the NiV
surface proteins. Vascular endothelial cells (ECs) are major targets of infection. Cytopathic effects
(CPE), characterized by syncytia formation and cell death, and an ensuing vasculitis, are a major
feature of the disease. Smooth muscle cells (SMCs) of the tunica media that line small blood vessels
are infected in humans and animal models of NiV disease, although pathology or histologic changes
associated with antigen-positive SMCs have not been reported. To gain an understanding of the
possible contributions that SMCs might have in the development of NiV disease, we investigated the
susceptibility and potential cytopathogenic changes of human SMCs to NiV infection in vitro. SMCs
were permissive for NiV infection and resulted in high titers and prolonged NiV production, despite
a lack of cytopathogenicity, and in the absence of detectable ephrin-B2/3. These results indicate that
SMC might be important contributors to disease by producing progeny NiV during an infection,
without suffering cytopathogenic consequences.Peer Reviewe
Enabling efficient engineering processes and automated analysis for power protection systems
The reliable operation of power networks depends on the correct configuration of protection systems. These systems involve the coordination of devices across a wide area, each with numerous setting parameters. Presently, protection settings data are typically stored in various vendor-specific proprietary formats, which are difficult to access, interchange, and manipulate automatically. Consequently, the engineering processes for implementing modern protection systems are extremely complex, involving multiple software tools from different vendors. This paper presents a novel solution to these challenges, through the use of the data model provided by the IEC 61850 standard, with the System Configuration description Language (SCL) format to represent protection settings data. The design of a Protection Setting data Conversion Tool (PSCT) that can automatically convert existing settings data between proprietary formats and the SCL-based format is presented. A case study of its implementation demonstrates the benefits of the common representation of protection settings for network operators and other stakeholders. The paper also addresses the challenges that network operators face in migrating to the new approach from existing legacy protection devices and data formats. Adoption of these recommendations and design approaches would shift protection systems from being largely single-vendor solutions to becoming efficient and truly open platforms, capable of supporting future intelligent applications and tools such as automated protection settings validation, diagnostics, and system simulation
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