The Diversity of High- and Intermediate-Velocity Clouds: Complex C versus IV Arch

We present Far Ultraviolet Spectroscopic Explorer (FUSE) and Space Telescope Imaging Spectrograph (STIS) observations of interstellar ultraviolet absorption lines in the Galactic high-velocity cloud Complex C and the Intermediate Velocity Arch (IV Arch) in direction of the quasar PG 1259+593 (l=120,b=+58 deg). Absorption lines from CII, NI, NII, OI, AlII, SiII, PII, SII, ArI, FeII, and FeIII are used to study the atomic abundances in these two halo clouds at V_LSR=-130 km/s (Complex C) and V_LSR=-55 km/s (IV Arch). The OI/HI ratio provides the best measure of the overall metallicity in the diffuse interstellar medium, because ionization effects do not alter the ratio, and oxygen is at most only lightly depleted from the gas into dust grains. For Complex C, we find an oxygen abundance of 0.093 (+0.125, -0.047) solar, consistent with the idea that Complex C represents the infall of low metallicity gas onto the Milky Way. In contrast, the oxygen abundance in the IV Arch is 0.98 (+1.21,-0.46) solar, which indicates a Galactic origin. We report the detection of an intermediate- velocity absorption component at +60 km/s that is not seen in HI 21cm emission. The clouds along the PG 1259+593 sight line have a variety of properties, proving that multiple processes are responsible for the creation and circulation of intermediate- and high-velocity gas in the Milky Way halo.Comment: 12 pages, 3 tables, 3 figures; accepted for publication in Ap

Datastreme Courses: Teacher Enhancement Utilizing Current Environmental Data and the Internet

The American Meteorological Society\u27s (AMS) Educational Program seeks to assist the improvement of science education in K-12 classrooms through implementation of the National Science Education Standards. This goal is being accomplished through the offering of three teacher enhancement courses via blended instruction methods. Following course participation each teacher functions as an Earth system science education resource person for his/her colleagues

Impact of Periodic Unsteadiness on Performance and Heat Load in Axial Flow Turbomachines

Results of an analytical and experimental investigation, directed at the understanding of the impact of periodic unsteadiness on the time-averaged flows in axial flow turbomachines, are presented. Analysis of available experimental data, from a large-scale rotating rig (LSRR) (low speed rig), shows that in the time-averaged axisymmetric equations the magnitude of the terms representing the effect of periodic unsteadiness (deterministic stresses) are as large or larger than those due to random unsteadiness (turbulence). Numerical experiments, conducted to highlight physical mechanisms associated with the migration of combustor generated hot-streaks in turbine rotors, indicated that the effect can be simulated by accounting for deterministic stress like terms in the time-averaged mass and energy conservation equations. The experimental portion of this program shows that the aerodynamic loss for the second stator in a 1-1/2 stage turbine are influenced by the axial spacing between the second stator leading edge and the rotor trailing edge. However, the axial spacing has little impact on the heat transfer coefficient. These performance changes are believed to be associated with the change in deterministic stress at the inlet to the second stator. Data were also acquired to quantify the impact of indexing the first stator relative to the second stator. For the range of parameters examined, this effect was found to be of the same order as the effect of axial spacing

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

AIMS: Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocytes/platelets promotes platelet hyperactivation. METHODS AND RESULTS: We generated a conditional mouse model where the insulin receptor (IR) was specifically knocked out in megakaryocytes/platelets and performed ex vivo platelet activation studies in wild-type (WT) and IR-deficient platelets by measuring aggregation, integrin αIIbβ3 activation, and dense and α-granule secretion. Deletion of IR resulted in an increase in platelet count and volume, and blocked the action of insulin on platelet signalling and function. Platelet aggregation, granule secretion, and integrin αIIbβ3 activation in response to the glycoprotein VI (GPVI) agonist collagen-related peptide (CRP) were significantly reduced in platelets lacking IR. This was accompanied by a reduction in the phosphorylation of effectors downstream of GPVI. Interestingly, loss of IR also resulted in a reduction in insulin-like growth factor-1 (IGF-1)- and insulin-like growth factor-2 (IGF-2)-mediated phosphorylation of IRS-1, Akt, and GSK3β and priming of CRP-mediated platelet activation. Pharmacological inhibition of IR and the IGF-1 receptor in WT platelets recapitulated the platelet phenotype of IR-deficient platelets. CONCLUSIONS: Deletion of IR (i) increases platelet count and volume, (ii) does not cause platelet hyperactivity, and (iii) reduces GPVI-mediated platelet function and platelet priming by IGF-1 and IGF-2

Integrity in democratic politics

The complaint that many professional politicians lack integrity is common. However, it is unclear what such a judgement amounts to. Taking various codes of political ethics in the United Kingdom as my starting point, I examine the extent to which we can understand political integrity as a matter of politicians adhering to the obligations that official codes of ethics prescribe and, in a more general sense, the public-service ethos that underpins these codes. I argue that although this way of approaching the issue usefully draws our attention to an important class of positional duties that apply to politicians, commitment to principled political causes plays a further, indispensable role in coherent assessments of political integrity. In consequence, I claim that politicians of integrity succeed in furthering their deepest political commitments while avoiding malfeasance or misconduct. As such, the ascription of political integrity can often only be made when assessing a long train of action