A Study Of The Effects Of Weekly Doses Of Niridazole On Schistosome Egg Output And Miricidial Hatching In A Patient Suffering From Bilharziasis

A CAJM article on "suppressive management" of bilharziasis.The concept of “suppressive management” in the control of bilharziasis has long been an attractive idea. If it were possible to administer a dose of a schistosomicidal drug once a week, particularly to children attending school, a significant reduction in egg output and an improvement in health would make the method worthy of careful consideration in bilharziasis control programmes

A Long-Term Study Of A Case Of Schistosoma Mansoni Subjected To Repeated Courses Of Treatment

A CAJM article on clinical testing and treatment for bilharziasis.The studies of the effects of treatment on individual patients suffering from bilharziasis has been a feature of the work of this Laboratory for some years (Blair et al. 1969b). From this work has emerged some interesting information on the disappearance and re-appearance of eggs and miracidia when treatment has failed. The earlier work was based on specimens of urine and stool passed by the patients from Monday to Friday only

Suppressive Therapy In The Control Of Bilharziasis: A Comparative Trial In African School Children

A CAJM article on the control of bilharzia-sis in Zimbabwean (Rhodesian) African children.One of the major problems facing the health service in any country which has a high prevalence of bilharziasis is the shortage of medical personnel required for the successful treatment of the large numbers of people who show infection. However, if a totally safe regime involving the administration of relatively innocuous drug at low dosages over long periods of time to control or suppress the level of infection in the person, the administration of the drug could then be left to the teachers or to other responsible members of the community. It is in this context that the policy of suppressive therapy or management of schistosome infections shows its greatest attraction

Confined granular packings: structure, stress, and forces

The structure and stresses of static granular packs in cylindrical containers are studied using large-scale discrete element molecular dynamics simulations in three dimensions. We generate packings by both pouring and sedimentation and examine how the final state depends on the method of construction. The vertical stress becomes depth-independent for deep piles and we compare these stress depth-profiles to the classical Janssen theory. The majority of the tangential forces for particle-wall contacts are found to be close to the Coulomb failure criterion, in agreement with the theory of Janssen, while particle-particle contacts in the bulk are far from the Coulomb criterion. In addition, we show that a linear hydrostatic-like region at the top of the packings unexplained by the Janssen theory arises because most of the particle-wall tangential forces in this region are far from the Coulomb yield criterion. The distributions of particle-particle and particle-wall contact forces $P(f)$ exhibit exponential-like decay at large forces in agreement with previous studies.Comment: 11 pages, 11 figures, submitted to PRE (v2) added new references, fixed typo

Stress Transmission through Three-Dimensional Ordered Granular Arrays

We measure the local contact forces at both the top and bottom boundaries of three-dimensional face-centered-cubic and hexagonal-close-packed granular crystals in response to an external force applied to a small area at the top surface. Depending on the crystal structure, we find markedly different results which can be understood in terms of force balance considerations in the specific geometry of the crystal. Small amounts of disorder are found to create additional structure at both the top and bottom surfaces.Comment: 9 pages including 9 figures (many in color) submitted to PR

Detection methods for non-Gaussian gravitational wave stochastic backgrounds

We address the issue of finding an optimal detection method for a discontinuous or intermittent gravitational wave stochastic background. Such a signal might sound something like popcorn popping. We derive an appropriate version of the maximum likelihood detection statistic, and compare its performance to that of the standard cross-correlation statistic both analytically and with Monte Carlo simulations. The maximum likelihood statistic performs better than the cross-correlation statistic when the background is sufficiently non-Gaussian. For both ground and space based detectors, this results in a gain factor, ranging roughly from 1 to 3, in the minimum gravitational-wave energy density necessary for detection, depending on the duty cycle of the background. Our analysis is exploratory, as we assume that the time structure of the events cannot be resolved, and we assume white, Gaussian noise in two collocated, aligned detectors. Before this detection method can be used in practice with real detector data, further work is required to generalize our analysis to accommodate separated, misaligned detectors with realistic, colored, non-Gaussian noise.Comment: 25 pages, 12 figures, submitted to physical review D, added revisions in response to reviewers comment

Automated mediator synthesis: combining behavioural and ontological reasoning

Software systems are increasingly composed of independently developed heterogeneous components. To ensure interoperability, mediators are needed that coordinate actions and translate exchanged messages between the components. We present a technique for automated synthesis of mediators, by means of a quotient operator, that is based on behavioural models of the components and an ontological model of the data domain. By not requiring a specification of the composed system, the method supports both off-line and run-time synthesis. The obtained mediator is the most general component that ensures freedom of both communication mismatches and deadlock in the composition. Validation of the approach is given by implementation of a prototype tool, while applicability is illustrated on heterogeneous holiday booking components

Effect of boundaries on the force distributions in granular media

The effect of boundaries on the force distributions in granular media is illustrated by simulations of 2D packings of frictionless, Hertzian spheres. To elucidate discrepancies between experimental observations and theoretical predictions, we distinguish between the weight distribution {\cal P} (w) measured in experiments and analyzed in the q-model, and the distribution of interparticle forces P(f). The latter one is robust, while {\cal P}(w) can be obtained once the local packing geometry and P(f) are known. By manipulating the (boundary) geometry, we show that {\cal P}(w) can be varied drastically.Comment: 4 pages, 4 figure

Statistics of the contact network in frictional and frictionless granular packings

Simulated granular packings with different particle friction coefficient mu are examined. The distribution of the particle-particle and particle-wall normal and tangential contact forces P(f) are computed and compared with existing experimental data. Here f equivalent to F/F-bar is the contact force F normalized by the average value F-bar. P(f) exhibits exponential-like decay at large forces, a plateau/peak near f = 1, with additional features at forces smaller than the average that depend on mu. Computations of the force-force spatial distribution function and the contact point radial distribution function indicate that correlations between forces are only weakly dependent on friction and decay rapidly beyond approximately three particle diameters. Distributions of the particle-particle contact angles show that the contact network is not isotropic and only weakly dependent on friction. High force-bearing structures, or force chains, do not play a dominant role in these three dimensional, unloaded packings.Comment: 11 pages, 13 figures, submitted to PR