Molecular analysis of apoptosis related genes DNA methylation status in endometrial carcinogenesis

Aberrant methylation in the promoters of genes associated with apoptosis was observed in many human cancers, but in the context of endometrial cancer only few publications have described the DNA methylation status of these genes. Apoptosis is a program cell death to maintain a tissue homeostasis in normal menstrual cycle. Disturbances in this pathway can promote cancer cell survival and furthermore are associated with resistance to therapy in endometrial cancer. Despite a high curability of this cancer type, prognosis of patients with advanced disease is still poor. One of the major mechanism of resistance to therapy is the aberrant DNA methylation pattern. Analysis of aberrant DNA methylation status can reveal early biomarkers in endometrial tumorigenesis and reflect apoptosis resistance development

Global methylation status in malignant brain tumor tissue

The DNA methylation is one of the main epigenetic inheritance form, which contributes in the regulation of gene expression. Abnormalities in DNA methylation processes can provide information about many pathophysiological conditions, including tumorigenesis. DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors. Glioblastoma (GB) is the most common and the most aggressive primary brain tumor in adults and therefore is considered one of the major issue in modern medicine

Characterization of dental tissue derived stem cells

Stem cells (SCs) are undifferentiated cells that are capable to differentiate into more specialized cells with specific functions. Oral tissues, which are easily accessible for dentists are a rich source of stem cells. The isolation of stem cells from these location may still not be convenient, because most of them requires surgical procedures, tooth or pulp extraction. Furthermore, these SCs are present in small quantities and can therefore be difficult to isolate, purify and homogenously expand them

Homocystene and human astrocytes

Astrocytes are multipotent and serve surprisingly large and diverse variety of functions, providing for the overall brain homeostasis, assisting in neurogenesis, determining the microarchitecture of the grey matter, and defending the brain through evolutionary conserved astrogliosis programs. Astrocytes are specifically involved in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases, and various forms of dementia. Homocysteine is a nonessential sulphur-containing amino acid that had been linked with neurodegenerative diseases and aging

Characterization of dental tissue derived stem cells

Stem cells (SCs) are undifferentiated cells that are capable to differentiate into more specialized cells with specific functions. Oral tissues, which are easily accessible for dentists are a rich source of stem cells. The isolation of stem cells from these location may still not be convenient, because most of them requires surgical procedures, tooth or pulp extraction. Furthermore, these SCs are present in small quantities and can therefore be difficult to isolate, purify and homogenously expand them

Homocystene and human astrocytes

Astrocytes are multipotent and serve surprisingly large and diverse variety of functions, providing for the overall brain homeostasis, assisting in neurogenesis, determining the microarchitecture of the grey matter, and defending the brain through evolutionary conserved astrogliosis programs. Astrocytes are specifically involved in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases, and various forms of dementia. Homocysteine is a nonessential sulphur-containing amino acid that had been linked with neurodegenerative diseases and aging