The DNA methylation is one of the main epigenetic inheritance form, which contributes in the regulation of gene expression. Abnormalities in DNA methylation processes can provide information about many pathophysiological conditions, including tumorigenesis. DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors. Glioblastoma (GB) is the most common and the most aggressive primary brain tumor in adults and therefore is considered one of the major issue in modern medicine
