‘A Problem Shared...?’ Some Reflections on Problem Solving Courts and Court Innovation in Australia

There has been growing interest in recent years in developing ‘non-adversarial’ forms of court based justice, and exploring the potential for courts to take a lead role in resolving the underlying issues that ensure repeated contact with the justice system for particular groups. Problem Oriented Courts, such as community courts, drug courts, family violence courts and the like, originated in the USA but have taken root in societies across the globe. This article emerges primarily out of research and policy development work intended to inform an initiative in Victoria Australia called the Next Generation Courts initiative, which sought mainstream the problem oriented approach by adopting the non-adversarial paradigm as the basis for all future court development in Victoria

Special Issue 1: Indigenous Perspectives and Counter Colonial Criminology

Abstract Night Patrols ('patrols'

E. Stanley and J. McCulloch (EDS), State Crime and Resistance

Non

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences between the histone substrate binding sites in order to improve affinity for the KDM4-subfamily over KDM5-subfamily enzymes. In particular, residues E169 and V313 (KDM4A numbering) were targeted. Additionally, the conformational restriction of the flexible pyridopyrimidinone C8-substituent was investigated. These approaches yielded potent and cell-penetrant dual KDM4/5-subfamily inhibitors including 19a (KDM4A and KDM5B Ki = 0.004 and 0.007 μM, respectively). Compound cellular profiling in two orthogonal target engagement assays revealed a significant reduction from biochemical to cell-based activity across multiple analogues; this decrease was shown to be consistent with 2OG competition, and suggest that sub-nanomolar biochemical potency will be required with C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one compounds to achieve sub-micromolar target inhibition in cells

Unsettling Colonial Automobilities: Criminalisation and Contested Sovereignties

Exploring the vehicle's role in imposing colonialism on Indigenous people, this book proposes an Indigenous automobility that reclaims sovereignty over place and centricity.</p