The finite topology and variational calculus on nontopological vector spaces

AbstractCertain aspects of the calculus of variations are presented in the setting of nontopological vector spaces, and the results are shown to have certain advantages in the investigation of various optimization problems of economics that seem more directly accessible by these techniques than by the maximum principle of optimal control theory

Social influences on flood preparedness and mitigation measures adopted by people living with flood risk

This paper aims to analyse evidence, based on one of the largest and most representative samples of households previously flooded or living with flood risk to date, of social patterns in a range of flood resilience traits relating to preparedness prior to a flood (e.g., property adaptations, contents insurance, etc.) and mitigations enacted during and immediately following a flood (e.g., receiving a warning, evacuation into temporary accommodation, etc.). The data were collected from a 2006 survey of 1223 households from a variety of locations across Scotland between one and twelve years after major local floods. Our analysis identifies remarkably few social differences in flood preparedness and mitigation measures, although some aspects of demography, housing and length of residence in an area, as well as personal flood history, are important. In light of this finding, we argue that social differences in vulnerability and resilience to flooding arise from deep-seated socio-economic and socio-spatial inequalities that affect exposure to flood risk and ability to recover from flood impacts. The engrained, but well-meaning, assumption in flood risk management that impoverished households and communities are lacking or deficient in flood preparedness or mitigation knowledge and capabilities is somewhat pejorative and misses fundamental, yet sometimes invisible, social stratifications play out in subtle but powerful ways to affect households’ and communities’ ability to avoid and recover from floods. We argue that general poverty and inequality alleviation measures, such as tax and welfare policy and urban and community regeneration schemes, are likely to be as, if not more, important in alleviating social inequalities in the long-term impacts of floods than social targeting of flood risk management policy

Social Influences on Flood Preparedness and Mitigation Measures Adopted by People Living with Flood Risk

From MDPI via Jisc Publications RouterHistory: accepted 2021-10-15, pub-electronic 2021-10-21Publication status: PublishedThis paper aims to analyse evidence, based on one of the largest and most representative samples of households previously flooded or living with flood risk to date, of social patterns in a range of flood resilience traits relating to preparedness prior to a flood (e.g., property adaptations, contents insurance, etc.) and mitigations enacted during and immediately following a flood (e.g., receiving a warning, evacuation into temporary accommodation, etc.). The data were collected from a 2006 survey of 1223 households from a variety of locations across Scotland between one and twelve years after major local floods. Our analysis identifies remarkably few social differences in flood preparedness and mitigation measures, although some aspects of demography, housing and length of residence in an area, as well as personal flood history, are important. In light of this finding, we argue that social differences in vulnerability and resilience to flooding arise from deep-seated socio-economic and socio-spatial inequalities that affect exposure to flood risk and ability to recover from flood impacts. The engrained, but well-meaning, assumption in flood risk management that impoverished households and communities are lacking or deficient in flood preparedness or mitigation knowledge and capabilities is somewhat pejorative and misses fundamental, yet sometimes invisible, social stratifications play out in subtle but powerful ways to affect households’ and communities’ ability to avoid and recover from floods. We argue that general poverty and inequality alleviation measures, such as tax and welfare policy and urban and community regeneration schemes, are likely to be as, if not more, important in alleviating social inequalities in the long-term impacts of floods than social targeting of flood risk management policy

In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency

AbstractAcute respiratory distress syndrome continues to be associated with significant morbidity and mortality related to ventilation-perfusion mismatch, pulmonary hypertension, and right ventricular failure. It has been suggested that inhaled nitric oxide, which is a selective pulmonary vasodilator, may be effective in the treatment of acute respiratory distress syndrome; however, the effects of nitric oxide on cardiopulmonary interactions are poorly understood. We therefore developed a model of acute lung injury that mimics the clinical syndrome of acute respiratory distress syndrome. In our model, inhaled nitric oxide significantly reduced pulmonary artery pressure, pulmonary vascular resistance, and pulmonary vascular impedance. In addition, inhaled nitric oxide improved transpulmonary vascular efficiency and ventilation-perfusion matching, which resulted in increased arterial oxygen tension. Although arterial oxygen tension increased, oxygen delivery did not improve significantly. These data suggest that by improving ventilation-perfusion matching and arterial oxygen tension while lowering pulmonary vascular resistance and impedance, nitric oxide may be beneficial in patients with acute respiratory distress syndrome. However, additional measures to enhance cardiac performance may be required. ( J THORAC CARDIOVASC SURG 1995;110: 593-600

Cognitive Information Processing

Contains reports on three research projects.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04)National Aeronautics and Space Administration (Grant NsG-496

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK

Objectives To assess consistency in the format and content, and overlap of subject and timing, of medication safety letters issued by regulatory health authorities to healthcare providers in Canada, the USA and the UK. Design A cross-sectional study comparing medication safety letters issued for the purpose of alerting healthcare providers to newly identified medication problems associated with medications already on the market. Setting Online databases operated by Health Canada, the US Food and Drug Administration and the UK Medicines and Healthcare products Regulatory Agency were searched to select medication safety letters issued between 1 January 2010 and 31 December 2014. Format, content and timing of each medication safety letter were assessed using an abstraction tool comprising 21 characteristics deemed relevant by consensus of the research team. Main outcome measures Main outcome measures included, first, characteristics (format and content) of medication safety letters and second, overlap of subject and release date across countries. Results Of 330 medication safety letters identified, 227 dealt with unique issues relating to medications available in all three countries. Of these 227 letters, 21 (9%) medication problems were the subject of letters released in all three countries; 40 (18%) in two countries and 166 (73%) in only one country. Only 13 (62%) of the 21 letters issued in all three countries were released within 6 months of each other. Conclusions Significant discrepancies in both the subject and timing of medication safety letters issued by health authorities in three countries (Canada, the USA and the UK) where medical practice is otherwise comparable, raising questions about why, how and when medication problems are identified and communicated to healthcare providers by the authorities. More rapid communication of medication problems and better alignment between authorities could enhance patient safety

No. 8 - The Cuban Embargo: Policy Outlook after 50 Years

Organized and sponsored by the Dean Rusk Center for International Law and Policy, The Cuban Embargo: Policy Outlook after 50 Years was a daylong conference exploring issues related to the impact of trade sanctions imposed by the United States on Cuba, pathways to lifting the embargo and potential U.S.-Cuba trade opportunities. Ambassador José R, Cabañas, the chief of mission at the Cuban Interests Section in Washinton, D.C., served as the keynote speaker for the event. The transcript of the conference proceedings has been edited for publication with the consent of the speakers

Status of Muon Collider Research and Development and Future Plans

The status of the research on muon colliders is discussed and plans are outlined for future theoretical and experimental studies. Besides continued work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy collider, many studies are now concentrating on a machine near 0.1 TeV (CoM) that could be a factory for the s-channel production of Higgs particles. We discuss the research on the various components in such muon colliders, starting from the proton accelerator needed to generate pions from a heavy-Z target and proceeding through the phase rotation and decay ($\pi \to \mu \nu_{\mu}$) channel, muon cooling, acceleration, storage in a collider ring and the collider detector. We also present theoretical and experimental R & D plans for the next several years that should lead to a better understanding of the design and feasibility issues for all of the components. This report is an update of the progress on the R & D since the Feasibility Study of Muon Colliders presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A. Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics (Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics, Accelerators and Beam