The Beagle 2 microscope

The Beagle 2 microscope provides optical images of the Martian surface at a resolution 5x higher than any other experiment currently planned. By using a novel illumination system it images in three colors and can also detect fluorescent materials

The microscope for the Beagle 2 lander on ESA's Mars Express

The microscope for the Beagle 2 lander on Mars Express will provide 4 µm per pixel images of rock and soil samples. The instrument is described and test results are presented

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy

BACKGROUND: A genetic defect in the epidermal barrier protein filaggrin plays a major role in the etiology of eczema and associated allergic airways diseases. However, it is still controversial to what extend loss-of-function (LOF) mutations in the filaggrin gene (FLG) contribute to the development and persistence of food allergies.OBJECTIVE: We tested association of FLG LOF mutations with allergic reactions to diverse foods and investigated their potential effect on the persistence of early food allergies. METHODS: We recruited 890 children with challenge-proven food allergy for the German Genetics of Food Allergy Study (GOFA). Longitudinal data were available for 684 children. All children were clinically characterized, including their allergic responses to specific foods, and genotyped for the four most common LOF mutations in FLG; R501X, 2282del4, R2447X, and S3247X. Associations between FLG mutations and food allergies were analyzed by logistic regression using the German Multicenter Allergy Study cohort as control population. RESULTS: FLG mutations were associated with allergies to diverse foods including hen's egg (HE), cow's milk (CM), peanut, hazelnut, fish, soy, cashew, walnut, and sesame with similar risk estimates. Effects remained significant after adjusting for the eczema status. Interestingly, FLG mutations increased the risk of a persistent course of HE and CM allergy. CONCLUSION: Using the gold standard for food allergy diagnosis, we demonstrate that FLG LOF mutations confer a risk of any food allergy independent of eczema. They predispose to the persistence of HE and CM allergy and should be considered in the assessment of tolerance development

Euclid Definition Study Report

Euclid is a space-based survey mission from the European Space Agency designed to understand the origin of the Universe's accelerating expansion. It will use cosmological probes to investigate the nature of dark energy, dark matter and gravity by tracking their observational signatures on the geometry of the universe and on the cosmic history of structure formation. The mission is optimised for two independent primary cosmological probes: Weak gravitational Lensing (WL) and Baryonic Acoustic Oscillations (BAO). The Euclid payload consists of a 1.2 m Korsch telescope designed to provide a large field of view. It carries two instruments with a common field-of-view of ~0.54 deg2: the visual imager (VIS) and the near infrared instrument (NISP) which contains a slitless spectrometer and a three bands photometer. The Euclid wide survey will cover 15,000 deg2 of the extragalactic sky and is complemented by two 20 deg2 deep fields. For WL, Euclid measures the shapes of 30-40 resolved galaxies per arcmin2 in one broad visible R+I+Z band (550-920 nm). The photometric redshifts for these galaxies reach a precision of dz/(1+z) \lt 0.05. They are derived from three additional Euclid NIR bands (Y, J, H in the range 0.92-2.0 micron), complemented by ground based photometry in visible bands derived from public data or through engaged collaborations. The BAO are determined from a spectroscopic survey with a redshift accuracy dz/(1+z) =0.001. The slitless spectrometer, with spectral resolution ~250, predominantly detects Ha emission line galaxies. Euclid is a Medium Class mission of the ESA Cosmic Vision 2015-2025 programme, with a foreseen launch date in 2019. This report (also known as the Euclid Red Book) describes the outcome of the Phase A study