322 research outputs found

    Неразрушающий контроль. Т. 3

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    В сборнике представлен широкий круг исследований аспирантов, студентов и молодых ученых Томска и других городов России. Сборник посвящен теоретическим и практическим аспектам неразрушающего контроля

    Exploring provision for children identified with special educational needs: an international review of policy and practice

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    This project aimed to create a descriptive map of international research which explores the notion of the continuum of educational provision for children with special educational needs. It also aimed to determine and examine the nature of how the continuum of provision is conceptualised, operationalised and enacted in a sample of selected countries. Commissioned by the National Council for Special Education, it also identified implications for the development of provision within the Irish context. The research involved a systematic identification and thematic review of theory, identifying and examining literature associated with the conceptualisation of the continuum; it examined the policy and provision across 55 administrations as publically reported, primarily to international agencies; it carried out more detailed examination of policy and practice in 10 countries using a survey and vignette study; and it involved a series of interviews with a range of individuals in a range of settings in four countries with differing approaches to supporting children with special educational needs. This paper outlines the overall findings of the research. It focuses in particular upon the need to change how we think about provision associated with continua, recognising the lack of international coherence in approaches to support for pupils with special educational needs. It identifies in particular the opportunities presented by a reconceptualisation of the class and the management of class resources, and the role key personnel can play in creating links between diverse services

    Opportunities to Learn Mathematics Pedagogy and Connect Classroom Learning to Practice: A Study of Future Teachers in the United States and Singapore

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    In this study, we conducted secondary analyses using the TEDS-M database to explore future mathematics specialists teachers’ opportunities to learn (OTL) how to teach mathematics. We applied latent class analysis techniques to differentiate among groups of prospective mathematics specialists with potentially different OTL mathematics pedagogy within the United States and Singapore. Within the United States, three subgroups were identified: (a) Comprehensive OTL, (b) Limited OTL, and (c) OTL Mathematics Pedagogy. Within Singapore, four subgroups were identified: (a) Comprehensive OTL, (b) Limited Opportunities to Connect Classroom Learning with Practice, (c) OTL Mathematics Pedagogy, and (d) Basic OTL. Understanding the opportunities different prospective teachers had to learn from and their experiences with different components of instructional practice in university and practicum settings has implications for teacher preparation programs

    Модернизация ректификационной колонны разделения пропан-пропиленовой фракции

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    Объектом проектирования является ректификационная колонна непрерывного действия для разделения пропан пропиленовой фракции, а также конденсатора-холодильника для конденсации пропилена. Целью работы является расчет ректификационной колонны и конденсатора-холодильника. В ходе расчета колонны был составлен материальный баланс колонны, рассчитано оптимальное флегмовое число и оптимальное значение числа теоретических тарелок. Так же был выполнен конструктивно-механический расчет. Входе которого определили исполнительную марку стали ректификационной колонны, условия прочности и устойчивости, найдены значения толщины стенки цилиндрической обечайки, эллиптических днища и крышки. Произведен расчет штуцеров и фланцев. В технологическом расчете теплообменника был составлен тепловой баланс. РассчитаныThe design object is a continuous distillation column for the separation of propane propylene fraction, as well as a condenser-cooler for condensation of propylene. The aim of the work is to calculate the distillation column and condenser-refrigerator. During the calculation of the column, the material balance of the column was compiled, the optimal reflux ratio and the optimal value of the number of theoretical plates were calculated. A structural and mechanical calculation was also performed. The inlet of which the executive grade of the distillation column was determined, the strength and stability conditions, the wall thickness of the cylindrical shell, elliptical bottom and cover were found. Calculation of fittings and flanges. In the technological calculation of the heat exchanger,

    Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology

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    INTRODUCTION Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain unclear. METHODS A total of 526 participants in early clinical stages of AD and controls from a longitudinal cohort were neurobiologically classified for amyloid and tau pathology applying the AT(N) system. Aβ and tau oligomers in the quantified cerebrospinal fluid (CSF) were measured using surface-based fluorescence intensity distribution analysis (sFIDA) technology. RESULTS Across groups, highest Aβ oligomer levels were found in A+ with subjective cognitive decline and mild cognitive impairment. Aβ oligomers were significantly higher in A+T− compared to A−T− and A+T+. APOE ε4 allele carriers showed significantly higher Aβ oligomer levels. No differences in tau oligomers were detected. DISCUSSION The accumulation of Aβ oligomers in the CSF peaks early within the AD continuum, preceding tau pathology. Disease-modifying treatments targeting Aβ oligomers might have the highest therapeutic effect in these disease stages. Highlights Using surface-based fluorescence intensity distribution analysis (sFIDA) technology, we quantified Aβ oligomers in cerebrospinal fluid (CSF) samples of the DZNE-Longitudinal Cognitive Impairment and Dementia (DELCODE) cohort Aβ oligomers were significantly elevated in mild cognitive impairment (MCI) Amyloid-positive subjects in the subjective cognitive decline (SCD) group increased compared to the amyloid-negative control group Interestingly, levels of Aβ oligomers decrease at advanced stages of the disease (A+T+), which might be explained by altered clearing mechanism
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