Detonation-flame arrester devices for gasoline cargo vapor recovery systems

Empirical data on the deflagration-to-detonation run-up distance for flowing mixtures of gasoline and air in 15.2-cm- (6.0-in.-) diameter piping simulating a vapor recovery system are presented. The quenching capability of eight selected flame control devices subjected to repeated stable detonations was evaluated. The successful detonation-flame arresters were: (1) spiral-wound, crimped aluminum ribbon, (2) foamed nickel-chrome metal, (3) vertically packed bed of aluminum Ballast rings, and (4) water-trap or hydraulic back-pressure valve. Installation configurations for two of the more applicable arresters, the spiral-wound, crimped stainless-steel ribbon and the vertically packed bed of aluminum Ballast rings, were further optimized by a series of parametric tests. The final configuration of these two arresters was demonstrated with repeated detonation tests at conditions that simulated vapor recovery system operation. On these tests, the combustible mixture of gasoline and air continued to flow through the piping for periods up to 120 seconds after the initial detonation had been arrested. There was no indication of continuous burning or reignition occurring on either side of the test arresters

Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy

SummaryBalance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecules for their effects on cell size. We find that statins, inhibitors of the mevalonate pathway, reduce cell proliferation and increase cell size and cellular protein density in various cell types, including primary human cells. Mevalonate pathway effects on cell size and protein density are mediated through geranylgeranylation of the small GTPase RAB11, which is required for basal autophagic flux. Our results identify the mevalonate pathway as a metabolic regulator of autophagy and expose a paradox in the regulation of cell size and proteostasis, where inhibition of an anabolic pathway can cause an increase in cell size and cellular protein density

Performance characterization tests of three 0.44-N (0.1 lbf) hydrazine catalytic thrusters

The 0.44-N (0.1-lbf) class of hydrazine catalytic thruster has been evaluated to assess its capability for spacecraft limit-cycle attitude control with thruster pulse durations on the order of 10 milliseconds. Dynamic-environment and limit-cycle simulation tests were performed on three commercially available thruster/valve assemblies, purchased from three different manufacturers. The results indicate that this class of thruster can sustain a launch environment and, when properly temperature-conditioned, can perform limit-cycle operations over the anticipated life span of a multi-year mission. The minimum operating temperature for very short pulse durations was determined for each thruster. Pulsing life tests were then conducted on each thruster under a thermally controlled condition which maintained the catalyst bed at both a nominal 93 C (200 F) and 205 C (400 F). These were the temperatures believed to be slightly below and very near the minimum recommended operating temperature, respectively. The ensuing life tests ranged from 100,000 to 250,000 pulses at these temperatures, as would be required for spacecraft limit-cycle attitude control applications

Identification of transcriptional and metabolic programs related to mammalian cell size

SummaryBackgroundRegulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and metabolomics.ResultsLarger cells displayed increased expression of cytoskeletal genes but unexpectedly repressed expression of many genes involved in mitochondrial functions. This effect appears to be cell autonomous because cultured Drosophila cells induced to increase cell size displayed a similar gene-expression pattern. Larger hepatocytes also displayed a reduction in the expression of lipogenic transcription factors, especially sterol-regulatory element binding proteins. Inhibition of mitochondrial functions and lipid biosynthesis, which is dependent on mitochondrial metabolism, increased the cell size with reciprocal effects on cell proliferation in several cell lines.ConclusionsWe uncover that large cell-size increase is accompanied by downregulation of mitochondrial gene expression, similar to that observed in diabetic individuals. Mitochondrial metabolism and lipid synthesis are used to couple cell size and cell proliferation. This regulatory mechanism may provide a possible mechanism for sensing metazoan cell size

Analyzing false memories in children with associative lists specific for their age

Two experiments attempted to resolve previous contradictory findings concerning developmental trends in false memories within the Deese-Roediger-McDermott (DRM) paradigm by using an improved methodology-constructing age-appropriate associative lists. The research also extended the DRM paradigm to preschoolers. Experiment 1 (N = 320) included children in three age groups (preschoolers of 3-4 years, second-graders of 7-8 years, and preadolescents of 11-12 years) and adults, and Experiment 2 (N = 64) examined preschoolers and preadolescents. Age-appropriate lists increased false recall. Although preschoolers had fewer false memories than the other age groups, they showed considerable levels of false recall when tested with age-appropriate materials. Results were discussed in terms of fuzzy-trace, source-monitoring, and activation frameworks

Cell size control - a mechanism for maintaining fitness and function

The maintenance of cell size homeostasis has been studied for years in different cellular systems. With the focus on ‘what regulates cell size’, the question ‘why cell size needs to be maintained’ has been largely overlooked. Recent evidence indicates that animal cells exhibit nonlinear cell size dependent growth rates and mitochondrial metabolism, which are maximal in intermediate sized cells within each cell population. Increases in intracellular distances and changes in the relative cell surface area impose biophysical limitations on cells, which can explain why growth and metabolic rates are maximal in a specific cell size range. Consistently, aberrant increases in cell size, for example through polyploidy, are typically disadvantageous to cellular metabolism, fitness and functionality. Accordingly, cellular hypertrophy can potentially predispose to or worsen metabolic diseases. We propose that cell size control may have emerged as a guardian of cellular fitness and metabolic activity

Gain without population inversion in V-type systems driven by a frequency-modulated field

We obtain gain of the probe field at multiple frequencies in a closed three-level V-type system using frequency modulated pump field. There is no associated population inversion among the atomic states of the probe transition. We describe both the steady-state and transient dynamics of this system. Under suitable conditions, the system exhibits large gain simultaneously at series of frequencies far removed from resonance. Moreover, the system can be tailored to exhibit multiple frequency regimes where the probe experiences anomalous dispersion accompanied by negligible gain-absorption over a large bandwidth, a desirable feature for obtaining superluminal propagation of pulses with negligible distortion.Comment: 10 pages + 8 figures; To appear in Physical Review

Doppler-free frequency modulation spectroscopy of atomic erbium in a hollow cathode discharge cell

The erbium atomic system is a promising candidate for an atomic Bose-Einstein condensate of atoms with a non-vanishing orbital angular momentum ($L \neq 0$) of the electronic ground state. In this paper we report on the frequency stabilization of a blue external cavity diode laser system on the 400.91 $nm$ laser cooling transition of atomic erbium. Doppler-free saturation spectroscopy is applied within a hollow cathode discharge tube to the corresponding electronic transition of several of the erbium isotopes. Using the technique of frequency modulation spectroscopy, a zero-crossing error signal is produced to lock the diode laser frequency on the atomic erbium resonance. The latter is taken as a reference laser to which a second main laser system, used for laser cooling of atomic erbium, is frequency stabilized

Quantum noise in the position measurement of a cavity mirror undergoing Brownian motion

We perform a quantum theoretical calculation of the noise power spectrum for a phase measurement of the light output from a coherently driven optical cavity with a freely moving rear mirror. We examine how the noise resulting from the quantum back action appears among the various contributions from other noise sources. We do not assume an ideal (homodyne) phase measurement, but rather consider phase modulation detection, which we show has a different shot noise level. We also take into account the effects of thermal damping of the mirror, losses within the cavity, and classical laser noise. We relate our theoretical results to experimental parameters, so as to make direct comparisons with current experiments simple. We also show that in this situation, the standard Brownian motion master equation is inadequate for describing the thermal damping of the mirror, as it produces a spurious term in the steady-state phase fluctuation spectrum. The corrected Brownian motion master equation [L. Diosi, Europhys. Lett. {\bf 22}, 1 (1993)] rectifies this inadequacy.Comment: 12 pages revtex, 2 figure