Combining Beamforming and Orthogonal Space-Time Block Coding

Abstract-Multiple transmit and receive antennas can be used in wireless systems to achieve high data rate communication. Recently, efficient space-time codes have been developed that utilize a large portion of the available capacity. These codes are designed under the assumption that the transmitter has no knowledge about the channel. In this work, on the other hand, we consider the case when the transmitter has partial, but not perfect, knowledge about the channel and how to improve a predetermined code so that this fact is taken into account. A performance criterion is derived for a frequency-nonselective fading channel and then utilized to optimize a linear transformation of the predetermined code. The resulting optimization problem turns out to be convex and can thus be efficiently solved using standard methods. In addition, a particularly efficient solution method is developed for the special case of independently fading channel coefficients. The proposed transmission scheme combines the benefits of conventional beamforming with those given by orthogonal space-time block coding. Simulation results for a narrow-band system with multiple transmit antennas and one or more receive antennas demonstrate significant gains over conventional methods in a scenario with nonperfect channel knowledge

Amlodipine+Benazepril is Superior to Hydrochlorothiazide+Benazepril Irrespective of Baseline Pulse Pressure: Subanalysis of the ACCOMPLISH Trial

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110751/1/jch12460.pd

Locally applied Simvastatin improves fracture healing in mice

<p>Abstract</p> <p>Background</p> <p>HMG-CoA reductase inhibitors, statins, are widely prescribed to lower cholesterol. High doses of orally administered simvastatin has previously been shown to improve fracture healing in a mouse femur fracture model. In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses.</p> <p>Methods</p> <p>Femur fractures were produced in 70 mature male Balb-C mice and stabilized with marrow-nailing. Three experiments were performed. Firstly, 20 mice received subcutaneous injections of either simvastatin (20 mg) or vehicle. Secondly, 30 mice were divided into three groups of 10 mice receiving continuous subcutaneous delivery of the vehicle substance, the vehicle with 5 mg or with 10 mg of simvastatin per kg bodyweight per day. Finally, in 20 mice, a silicone tube was led from an osmotic mini-pump to the fracture area. In this way, 10 mice received an approximate local dose of simvastatin of 0.1 mg per kg per day for the duration of the experiment and 10 mice received the vehicle compound. All treatments lasted until the end of the experiment. Bilateral femurs were harvested 14 days post-operative. Biomechanical tests were performed by way of three-point bending. Data was analysed with ANOVA, Scheffé's post-hoc test and Student's unpaired t-test.</p> <p>Results</p> <p>With daily simvastatin injections, no effects could be demonstrated for any of the parameters examined. Continuous systemic delivery resulted in a 160% larger force at failure. Continuous local delivery of simvastatin resulted in a 170% larger force at failure as well as a twofold larger energy uptake.</p> <p>Conclusion</p> <p>This study found a dramatic positive effect on biomechanical parameters of fracture healing by simvastatin treatment directly applied to the fracture area.</p

Code profiling as a design tool for application specific instruction sets

As the embedded devices has become more and more generalized and as their product cycles keeps shrinking the field has opened up for the Application Specific Instruction set Processor. A mix between the classic generalized microcontroller and the specialized ASIC the ASIP keeps a set of general processing instructions for executing embedded software but combines that with a set of heavily specialized instructions for speeding up the data intense application core algorithms. One important aspect of the ASIP design flow research is cutting design time and cost. One way of that is automation of the instruction set design. In order to do so a process is needed where the algorithm to be ASIPed is analyzed and critical operations are found and exposed so that they can be implemented in special hardware. This process is called profiling. This thesis describes an implementation of a fine grained source code profiler for use in an ASIP design flow. The profiler software is based on a static-dynamic workflow where data is assembled from both static analysis and dynamic execution of the program and then analyzed together in an specially made analysis software

Following the mevalonate pathway to bone heal alley

The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. Using two different rodent models of fracture repair, a commonly used cholesterol lowering drug (statin) and two drugs used to treat osteoporosis (bisphosphonate) were applied both systemically as well as locally in order to enhance fracture repair. Papers I and II investigate the potential of simvastatin to improve the healing of femoral fractures in mice. Papers III and IV explore the use of two bisphosphonates to improve early fixation of stainless steel screws into rat bone. The statin simvastatin lead to an increased strength of the healing cellus. The application of bisphosphonates increased early screw fixation. It seems clear that both drugs have uses in orthopaedic applications. One interesting avenue of further research would be to combine the two classes of drugs and see if we can get the benefits while at the same time diminishing the drawbacks

Towards a goal and problem based business process improvement framework – an experience report

The interest in business process improvement (BPI) is vast among researchers and practitioners. However, it is difficult for an organisation to understand which BPI methods to introduce given a situation at hand. This paper describes experiences from a major Swedish insurance company that carried out a BPI project but needed to know if further improvement could be achieved. In order to address this issue, a BPI framework was designed and applied on already improved business process diagrams. The BPI framework consists of various BPI tasks from different BPI methods, more precisely Six Sigma and Lean, and from research on so called duplicate systems. The framework also consists of goal and problem statements related to BPI tasks. These goals and problem statements aim to support the selection, combina-tion, and application of the BPI tasks given a situation at hand. The application of the BPI framework showed that several further improvements of already improved business processes diagrams could be achieved. An evaluation of the BPI framework based on interviews with academic experts and practitioners also showed promising results