372 research outputs found
Programme cantonal diabète dans le canton de Vaud indicateurs pour le suivi et le baromètre : rapport final
Le Programme cantonal Diabète souhaite collecter des indicateurs afin d'objectiver son suivi et produire un Baromètre Diabète Vaud qui serait publié et distribué périodiquement à un public large. Ce rapport présente les indicateurs suggérés par l'IUMSP, mandaté afin d'établir une liste raisonnée d'indicateurs sur le diabète pour le canton de Vaud. La sélection d'indicateurs s'est faite d'après plusieurs critères, parmi lesquels la disponibilité des indicateurs actuelle et à long terme, ainsi que leur pertinence avérée par la littérature. Ce rapport décrit les résultats pour les indicateurs sélectionnés, ainsi que les informations nécessaires à leur compréhension : source, fréquence de mise à disposition, méthode de calcul, limites, références éventuelles. Parmi les indicateurs décrits dans ce rapport, certains sont proposés comme spécialement pertinents à inclure dans le futur Baromètre Diabète Vaud. Aussi, une suggestion de présentation de ces indicateurs (fiches descriptives) est articulée pour ce dernier
Sex- and melanism-specific variations in the oxidative status of adult tawny owls in response to manipulated reproductive effort.
Oxidative stress, determined by the balance between the production of damaging reactive oxygen species (ROS) and antioxidant defences, is hypothesized to play an important role in shaping the cost of reproduction and life history trade-offs. To test this hypothesis, we manipulated reproductive effort in 94 breeding pairs of tawny owls (Strix aluco) to investigate the sex- and melanism-specific effects on markers of oxidative stress in red blood cells (RBCs). This colour polymorphic bird species shows sex-specific division of labour and melanism-specific history strategies. Brood sizes at hatching were experimentally enlarged or reduced to increase or decrease reproductive effort, respectively. We obtained an integrative measure of the oxidative balance by measuring ROS production by RBCs, intracellular antioxidant glutathione levels and membrane resistance to ROS. We found that light melanic males (the sex undertaking offspring food provisioning) produced more ROS than darker conspecifics, but only when rearing an enlarged brood. In both sexes, light melanic individuals had also a larger pool of intracellular antioxidant glutathione than darker owls under relaxed reproductive conditions (i.e. reduced brood), but not when investing substantial effort in current reproduction (enlarged brood). Finally, resistance to oxidative stress was differently affected by the brood size manipulation experiment in males and females independently of their plumage coloration. Altogether, our results support the hypothesis that reproductive effort can alter the oxidative balance in a sex- and colour-specific way. This further emphasizes the close link between melanin-based coloration and life history strategies
A Search for Variations of Fundamental Constants using Atomic Fountain Clocks
Over five years we have compared the hyperfine frequencies of 133Cs and 87Rb
atoms in their electronic ground state using several laser cooled 133Cs and
87Rb atomic fountains with an accuracy of ~10^{-15}. These measurements set a
stringent upper bound to a possible fractional time variation of the ratio
between the two frequencies : (d/dt)ln(nu_Rb/nu_Cs)=(0.2 +/- 7.0)*10^{-16}
yr^{-1} (1 sigma uncertainty). The same limit applies to a possible variation
of the quantity (mu_Rb/mu_Cs)*alpha^{-0.44}, which involves the ratio of
nuclear magnetic moments and the fine structure constant.Comment: 4 pages, 3 figures, 1 table submitted to Phys. Rev. Let
Leptin and smoking cessation: secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation.
BACKGROUND: Smokers have a lower body weight compared to non-smokers. Smoking cessation is associated with weight gain in most cases. A hormonal mechanism of action might be implicated in weight variations related to smoking, and leptin might be implicated. We made secondary analyses of an RCT, with a hypothesis-free exploratory approach to study the dynamic of leptin following smoking cessation.
METHODS: We measured serum leptin levels among 271 sedentary smokers willing to quit who participated in a randomized controlled trial assessing a 9-week moderate-intensity physical activity intervention as an aid for smoking cessation. We adjusted leptin for body fat levels. We performed linear regressions to test for an association between leptin levels and the study group over time.
RESULTS: One year after smoking cessation, the mean serum leptin change was +3.23 mg/l (SD 4.89) in the control group and +1.25 mg/l (SD 4.86) in the intervention group (p of the difference < 0.05). When adjusted for body fat levels, leptin was higher in the control group than in the intervention group (p of the difference < 0.01). The mean weight gain was +2.91 (SD 6.66) Kg in the intervention and +3.33 (SD 4.47) Kg in the control groups, respectively (p not significant).
CONCLUSIONS: Serum leptin levels significantly increased after smoking cessation, in spite of substantial weight gain. The leptin dynamic might be different in chronic tobacco users who quit smoking, and physical activity might impact the dynamic of leptin in such a situation.
CLINICAL TRIAL REGISTRATION NUMBER: NCT00521391
Transitionless quantum drivings for the harmonic oscillator
Two methods to change a quantum harmonic oscillator frequency without
transitions in a finite time are described and compared. The first method, a
transitionless-tracking algorithm, makes use of a generalized harmonic
oscillator and a non-local potential. The second method, based on engineering
an invariant of motion, only modifies the harmonic frequency in time, keeping
the potential local at all times.Comment: 11 pages, 1 figure. Submitted for publicatio
Testing the stability of fundamental constants with the 199Hg+ single-ion optical clock
Over a two-year duration, we have compared the frequency of the 199Hg+ 5d106s
2S 1/2 (F=0) 5d9 6s2 2D 5/2 (F=2) electric-quadrupole transition at 282 nm
with the frequency of the ground-state hyperfine splitting in neutral 133Cs.
These measurements show that any fractional time variation of the ratio
nu(Cs)/nu(Hg) between the two frequencies is smaller than +/- 7 10^-15 / yr (1
sigma uncertainty). According to recent atomic structure calculations, this
sets an upper limit to a possible fractional time variation of g(Cs) m_e / m_p
alpha^6.0 at the same level.Comment: 4 pages with 3 figures. RevTeX 4, Submitted to Phys. Rev. Let
Le diabète dans le canton de Vaud : évaluation de la pratique des professionnel(le)s de santé et de la collaboration interprofessionnelle
Contexte: Le Programme cantonal diabète se développe depuis 2010 dans le canton de Vaud. Il a pour objectif de limiter l'évolution de l'incidence du diabète et d'améliorer la prise en charge des patients diabétiques. - Méthodes: Cette étude vise à recueillir des données concernant : 1) la collaboration interprofessionnelle, 2) la pratique professionnelle au regard du « Chronic care model », ainsi que 3) la connaissance et la mise en pratique des recommandations pour la pratique clinique (RPC) auprès du patient diabétique. Les professionnels de santé (PdS) suivant ont été sollicités pour participer à cette étude : médecins et infirmier(ère)s spécialisé(e)s en diabétologie, médecins de premiers recours et infirmier(ère)s en soins généraux. Cette étude comporte un volet quantitatif où les PdS étaient invités à répondre à un questionnaire sur Internet, et un volet qualitatif où des PdS ont été réunis lors de trois focus groups pour recueillir leurs avis sur les trois thématiques de l'étude
Cold atom Clocks and Applications
This paper describes advances in microwave frequency standards using
laser-cooled atoms at BNM-SYRTE. First, recent improvements of the Cs
and Rb atomic fountains are described. Thanks to the routine use of a
cryogenic sapphire oscillator as an ultra-stable local frequency reference, a
fountain frequency instability of where
is the measurement time in seconds is measured. The second advance is a
powerful method to control the frequency shift due to cold collisions. These
two advances lead to a frequency stability of at 7\times 10^{-16}^{87}^{133}$Cs fountains.
Finally we give an update on the cold atom space clock PHARAO developed in
collaboration with CNES. This clock is one of the main instruments of the
ACES/ESA mission which is scheduled to fly on board the International Space
Station in 2008, enabling a new generation of relativity tests.Comment: 30 pages, 11 figure
New Limits to the Drift of Fundamental Constants from Laboratory Measurements
We have remeasured the absolute - transition frequency in atomic hydrogen. A comparison with the result of the previous
measurement performed in 1999 sets a limit of Hz for the drift of
with respect to the ground state hyperfine splitting in Cs. Combining this result with the recently published
optical transition frequency in Hg against and a
microwave Rb and Cs clock comparison, we deduce separate limits
on yr and the
fractional time variation of the ratio of Rb and Cs nuclear magnetic moments
equal to
yr. The latter provides information on the temporal behavior of the
constant of strong interaction.Comment: 4 pages, 3 figures, LaTe
Coulomb energy contribution to the excitation energy in Th and enhanced effect of variation
We calculated the contribution of Coulomb energy to the spacing between the
ground and first excited state of Th nucleus as a function of the
deformation parameter . We show that despite the fact that the odd
particle is a neutron, the change in Coulomb energy between these two states
can reach several hundreds KeV.This means that the effect of the variation of
the fine structure constant may be enhanced
times in the 7.6 eV "nuclear clock" transition
between the ground and first excited states in the Th nucleus.Comment: 6 pages,2 figure
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