Not All Your Neighbors Are Free: Community Building with Incarcerated Folks in San Luis Obispo

The American criminal justice system is rooted in white supremacist ideology that is predicated on the murder, displacement, exploitation, and marginalization of people of color. Scholars and activists recognize the American prison system as a modern form of slavery. Only three miles away from Cal Poly’s campus, the California Men’s Colony State Prison (CMC) operates as one of thirty-four state prisons in California. Nearly 4,000 men, trans women, and nonbinary people are being held at the CMC. Not only can mass incarceration be identified as one of the most dreadful state projects that violates human freedom, but also non-incarcerated community members have little to no means of assuring the safety and rights of those incarcerated. Through combining the narratives of currently and formerly incarcerated folks at the CMC, facilitating meetings with community members, engaging with contemporary scholarship and literature surrounding the American carceral system, and investigating the conditions and programming of other state prisons, I have formulated a plan for programming to be launched in the CMC through the NAACP. The men I talked to in the CMC, though few, all expressed a tremendous interest in restorative justice, social problems, outlets for self-expression, and desire to engage with the outside world. Therefore, my project includes an in-depth analysis and report on prisons, using the CMC as a site of reference and investigation, as well as a tangible plan of action to support and enrich people\u27s lives by developing a program that prioritizes the folks at the CMC’s longings for community, opportunities, and knowledge

Necrocapitalism and U.S. Imperialism: The Gulf War, Hurricane Katrina, Palestine, Gentrification, and Police

U.S. American law has been responsible for slavery and genocide through the use of imperial forces such as the military and policing since the beginning of the formation of this nation. In this essay, I present contemporary forms of State sanctioned violence that have ultimately increased the United States’ economy through rendering particular communities as disposable. I use examples of war, removal, occupation, and murder perpetrated by American law in order to disrupt the notion that law guarantees security. Furthermore; I build from Foucault’s theories of biopolitics and apply a more modern framework of necrocapitalism to further contextualize and problematize concurrent, violent injustices being executed through the weaponization of American law

Governmental intervention in foreign trade in archaic and classical Greece.

The thesis discusses the role of the state in archaic and classical Greek trade through the study of four commodities, gold, silver, timber and grain, where the state had reason to intervene. Gold and silver were not only a major source of wealth for the producing states but also their import was a concern for many states, since they were the main coinage metals. In the thesis, both the role of the state in production and export and the situation for coin-minting importers using statistical data for silver and case studies for gold are discussed. The study of timber concentrates on shipbuilding timber, particularly for triremes, since naval warfare played such an important role in the historical developments of the classical period. The two main issues discussed are the intervention through monopoly and the means of acquisition used by the importers, concentrating on coercive diplomacy and military pressure. Grain was the main staple food in antiquity and for many poleis its import, regular and extraordinary, was a matter of life or death. The economic policies of the exporters in normal and famine situations and the intervention of the state in imports through legislation are discussed. The thesis shows that Greek states both intervened and involved themselves rationally in the production, export and import of important commodities disproving the modern orthodoxy on the issue, which argues in favour of minimal extraordinary intervention

CONSTRUCTION AND EVALUATION OF RECOMBINANT IMMUNOGENS AS THERAPEUTIC VACCINES AGAINST HPV-RELATED CANCERS

Background Considering the high number of new cases of cervical cancer each year caused by human papilloma viruses (HPVs), the development of an effective vaccine for the prevention and therapy of HPV-associated cancers, and in particular against the high-risk HPV-16 genotype, remains a priority. Vaccines expressing the E6 and E7 proteins, which are detectable in all HPV-positive pre-cancerous and cancer cells, might support the treatment of HPV-related lesions and clear already established tumors. Methods In this study, DNA and fowlpox virus recombinants expressing the E6F47R and E7GGG mutated forms of the HPV-16 E6 and E7 oncoproteins were generated, and their correct expression verified by RT-PCR, Western blotting and immunofluorescence. The immune responses were determined by ELISA and ELISPOT assays and the therapeutic efficacy was evaluated In mice, as a pre-clinical model of HPV-16 tumorigenicity, using heterologous (DNA/FP) or homologous (DNA/DNA and FP/FP) prime/ boost regimens after challenge with syngeneic TC-1* cells. Results The analyses of the different recombinants showed the correct expression of the inserted heterologous genes. After mice immunization, while specific anti-E6 and anti-E7 humoral responses were just detectable, specific T-cell responses were elicited. In the therapeutic protocols, after the challenge and the subsequent immunizations, a delay in cancer appearance was shown, thus confirming the pivotal role of the T-cell response in the control of tumor growth also in the absence of E6- and E7-specific antibodies. These in-vivo experiments resulted in higher numbers of tumor-free mice after either the homologous or heterologous immunizations compared to the controls. Conclusions These data establish a preliminary indication for the prevention and treatment of HPV-related tumors by the use of DNA and avipox constructs as safe and effective immunogens administered by the prime/boost strategy. The combined use of the recombinants expressing both the E6F47R and E7GGG proteins should improve the antitumor efficacy and represent an important approach to control/clear HPV-associated cancers

Women Entrepreneurship: An Analysis of Bikaner District

Women play an important role in the development of society and country as whole. If a country wants to develop then it has to realise the importance of the contribution of women in increasing the economy of country. This paper is an effort to study the socio-economic condition of women of western Rajasthan, profile of women entrepreneurs of Bikaner region. It also attempts to study the motivational factors for starting the business. It also tries to identify the challenges faced by women in starting and managing the business enterprise. The women entrepreneurs dealing in beauty parlour, boutique shops and tailoring units are selected. Study suggests that Entrepreneurship awareness camps should be organised at college levels

Recursos potenciais de grupos caçadores-coletores do médio rio Ribeira (SP).

Estudos fitossociológicos realizados em duas áreas no domínio das florestas tropicais do médio vale do Rio Ribeira mostram que a região apresenta grande homogeneidade ecológica, embora existam diferenças locais. As condições clim áticas e topográficas da região eram propícias para o assentamento de caçadores-coletores, que dispunham de uma variedade ampla de recursos vegetais existentes, notadamente frutos, nas diversas épocas do ano.Phytosociological studies carried out in two Atlantic rain forest areas in the middle valley of the Ribeira river, show that the region presents a great ecological homogeneity, although there are some local differences. Climatic and topographic conditions of the region are appropriate for the settlement of huntergatherers, who had at their disposal a wide range of vegetable resources, mainly fruits, available at different times of the year

Development of Novel Machine Learning to Optimize the Solubility of Azathioprine as Anticancer Drug in Supercritical Carbon Dioxide

Supercritical carbon dioxide (Sc-CO2) has thus been proposed as an appropriate solvent for diluting the pharmaceuticals to increase particle size. The use of supercritical fluids (SCFs) in various industrial applications, such as extraction, chromatography, and particle engineering, has attracted considerable interest. Recognizing the solubility behavior of various drugs is an essential step in the pharmaceutical industry's pursuit of the most effective supercritical approach. In this work, four models were used to predict the solubility of Azathioprine in supercritical carbon dioxide, including Ridge regression (RR), Huber regression (HR), Random forest (RF), and Gaussian process regression (GPR). The R-squared scores of all four models are 0.974, 0.6518, 0.966, and 1.0 for Ridge regression (RR), Huber regression (HR), Random forest (RF), and Gaussian process regression (GPR) models, respectively. The RMSE error rates of 2.843 ×10-13, 7.036 ×10-12, 5.673 ×10-13, and 1.054 ×10-30 for the RR, HR, RF, and GPR models, respectively. MAE metrics of 1.205 ×10-6, 2.151  ×10-6, 5.997 ×10-7 and 9.419 ×10-16 errors were also found in the RR, HR, RF, and GPR models, respectively. It was found that Ridge regression (RR), Random forest (RF), and Gaussian process regression (GPR) models can be used to predict any compound's solubility in supercritical carbon dioxide