Cardiovascular risk and emotion regulation contribute to depression symptomatology in middle-aged and older autistic adults

Background: Cardiovascular risk factors (CVRF) and executive function difficulties increase during later-life and are associated with depression symptoms among non-autistic older people. These associations, however, have not yet been explored among middle-aged and older autistic people. Methods: Using data collected via Simons Foundation Powering Autism Research (SPARK), Research Match, we examined the frequency of CVRF, and associations between CVRF, executive function and depression symptoms in 387 middle-aged and older autistic people (aged 40-83 years). Results: Autistic adults reported high rates of CVRF (two, 28.9%; three or more, 23.2%). Rates of high cholesterol and obesity were greater among middle-aged and older autistic adults compared to the general population. CVRF, age, and emotion regulation (but not inhibitory control), were significantly associated with depression symptoms in middle-aged and older autistic adults. Conclusions: CVRF occur at high rates in middle-aged and older autistic adults, and it is important that healthcare providers monitor risk factors in order to implement preventative strategies. CVRF are associated with depressive symptoms among middle-aged and older autistic adults, but may not be as important as difficulties with emotion regulation

The Low-Latitude Ionosphere/Thermosphere Enhancements in Density (LLITED) Mission

The Low-Latitude Ionosphere/Thermosphere Enhancements in Density (LLITED) CubeSat mission is a NASA funded HTIDs project. It is a 3-year grant with two 1.5U CubeSats with an estimated delivery in the spring of 2020 and a 1- year on-orbit mission life. Each CubeSat will host a miniature ionization gauge space instrument (MIGSI), planar ion probe (PIP), and GPS radio occultation sensor (CTECS-A). The mission is to provide both ionosphere and thermosphere measurements related to the Equatorial Ionization Anomaly (EIA) and the Equatorial Temperature and Wind Anomaly (ETWA). The EIA and ETWA are two of the dominant ionosphere/thermosphere interactions on the low-latitude duskside. While the EIA has been extensively studied both observationally and with modeling, the ETWA is less well known since observations are infrequent due to a lack of suitably instrumented spacecraft (s/c) at appropriate altitudes. LLITED will, for the first time, provide coincident high-resolution measurements of the duskside ionosphere/thermosphere at lower altitudes that will characterize and improve our understanding of the ETWA, provide insight into the coupling physics between the ETWA and EIA, and increase our knowledge of the duskside dynamics that may influence space weather. The following paper reviews the science mission and concepts and then provides the current status of the LLITED hardware

Opportunities for Improving Livestock Production with e-Management Systems

There is increased interest in hardware and software that can support e-Management for grassland-based livestock industries. Managers of grazing livestock were early adopters of radio frequency identification (RFID) technologies automatically monitoring individual animal performance. Recent developments of remote sensing, automated individual recording and management, location based systems, improved data transfer and technologies that can be used in more extensive grazing systems are providing new opportunities for the development of e-Management systems. There is a need for better data integration and systems that can provide the best available information to enable better decision-making. For greater industry adoption of more integrated e-Management systems, there needs to be a clear economic value. With increased on farm monitoring and the expansion of digital data sources, grazing livestock production systems have the opportunity to expand production efficiency through the implementation of e-Management

Foreign Aid

The goal of this presentation is to demonstrate the research regarding foreign aid. We will present how foreign aid is received in the nations of Russia, Afghanistan, and Haiti to incorporate three different regions of the world. First, we will define foreign aid by reviewing its history in comparison to how it is practiced today. We will also look at why the United States initially decided to provide foreign aid to the referenced countries, but how the original intent actually caused issues and concerns within these countries and provided little to no actual help. In addition, we will expose the problem of dependency the discussed countries have on the United States due to the current process of foreign aid. Lastly, we will present four questions to ask when researching the best methods of cross-cultural aid and a suggested call to action. By reviewing the different aspects of foreign aid, we hope to educate our audience on ways it can either weaken or empower receiving countries

Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use

Approximately 40% of American adults are affected by cardiovascular disease (CVD) risk factors (e.g., high blood pressure, high cholesterol, diabetes, and overweight or obesity), and risk among autistic adults may be even higher. Mechanisms underlying the high prevalence of CVD risk factors in autistic people may include known correlates of CVD risk factors in other groups, including high levels of perceived stress, poor sleep quality, and antipsychotic medication use. A sample of 545 autistic adults without intellectual disability aged 18+ were recruited through the Simons Foundation Powering Autism Research, Research Match. multiple linear regression models examined the association between key independent variables (self-reported perceived stress, sleep quality, and antipsychotic medication use) and CVD risk factors, controlling for demographic variables (age, sex assigned at birth, race, low-income status, autistic traits). Overall, 73.2% of autistic adults in our sample had an overweight/obesity classification, 45.3% had high cholesterol, 39.4% had high blood pressure, and 10.3% had diabetes. Older age, male sex assigned at birth, and poorer sleep quality were associated with a higher number of CVD risk factors. Using antipsychotic medications was associated with an increased likelihood of having diabetes. Poorer sleep quality was associated with an increased likelihood of having an overweight/obesity classification. Self-reported CVD risk factors are highly prevalent among autistic adults. Both improving sleep quality and closely monitoring CVD risk factors among autistic adults who use antipsychotic medications have the potential to reduce risk for CVD

Monitoring Animal Behaviour and Environmental Interactions Using Wireless Sensor Networks, GPS Collars and Satellite Remote Sensing

Remote monitoring of animal behaviour in the environment can assist in managing both the animal and its environmental impact. GPS collars which record animal locations with high temporal frequency allow researchers to monitor both animal behaviour and interactions with the environment. These ground-based sensors can be combined with remotely-sensed satellite images to understand animal-landscape interactions. The key to combining these technologies is communication methods such as wireless sensor networks (WSNs). We explore this concept using a case-study from an extensive cattle enterprise in northern Australia and demonstrate the potential for combining GPS collars and satellite images in a WSN to monitor behavioural preferences and social behaviour of cattle

Development of Level 1b Calibration and Validation Readiness, Implementation and Management Plans for GOES-R

A complement of Readiness, Implementation and Management Plans (RIMPs) to facilitate management of post-launch product test activities for the official Geostationary Operational Environmental Satellite (GOES-R) Level 1b (L1b) products have been developed and documented. Separate plans have been created for each of the GOES-R sensors including: the Advanced Baseline Imager (ABI), the Extreme ultraviolet and X-ray Irradiance Sensors (EXIS), Geostationary Lightning Mapper (GLM), GOES-R Magnetometer (MAG), the Space Environment In-Situ Suite (SEISS), and the Solar Ultraviolet Imager (SUVI). The GOES-R program has implemented these RIMPs in order to address the full scope of CalVal activities required for a successful demonstration of GOES-R L1b data product quality throughout the three validation stages: Beta, Provisional and Full Validation. For each product maturity level, the RIMPs include specific performance criteria and required artifacts that provide evidence a given validation stage has been reached, the timing when each stage will be complete, a description of every applicable Post-Launch Product Test (PLPT), roles and responsibilities of personnel, upstream dependencies, and analysis methods and tools to be employed during validation. Instrument level Post-Launch Tests (PLTs) are also referenced and apply primarily to functional check-out of the instruments

Prisoners Teaching ESL: A Learning Community among “Language Partners”

A program in which prisoners teach ESL classes, supported by volunteer teacher-trainers, is a learning community with immense and sometimes unforeseen value

Effects of geolocators on hatching success, return rates, breeding movements, and change in body mass in 16 species of Arctic-breeding shorebirds

Additional Authors: Bruce Casler; Maureen Christie; Jonathan T. Coleman; Jesse R. Conklin; Willow B. English; H. River Gates; Olivier Gilg; Marie-Andrée Giroux; Ken Gosbell; Chris Hassell; Jim Helmericks; Andrew Johnson; Borgný Katrínardóttir; Kari Koivula; Jean-Francois Lamarre; Johannes Lang; David B. Lank; Nicolas Lecomte; Joe Liebezeit; Vanessa Loverti; Laura McKinnon; Clive Minton; David Mizrahi; Erica Nol; Veli-Matti Pakanen; Johanna Perz; Ron Porter; Jennie Rausch; Jeroen Reneerkens; Nelli Rönkä; Sarah Saalfeld; Nathan Senner; Benoît Sittler; Paul A. Smith; Kristine Sowl; Audrey Taylor; David H. Ward; Stephen YezerinacCitation: Weiser, E.L., R.B. Lanctot, S.C. Brown, J.A. Alves, P.F. Battley, R. Bentzen, J. Bêty, M.A. Bishop, M. Boldenow, L. Bollache, B. Casler, M. Christie, J.T. Coleman, J.R. Conklin, W.B. English, H.R. Gates, O. Gilg, M.-A. Giroux, K. Gosbell, C. Hassell, J. Helmericks, A. Johnson, B. Katrínardóttir, K. Koivula, E. Kwon, J.-F. Lamarre, J. Lang, D.B. Lank, N. Lecomte, J. Liebezeit, V. Loverti, L. McKinnon, C. Minton, D. Mizrahi, E. Nol, V.-M. Pakanen, J. Perz, R. Porter, J. Rausch, J. Reneerkens, N. Rönkä, S. Saalfeld, N. Senner, B. Sittler, P.A. Smith, K. Sowl, A. Taylor, D.H. Ward, S. Yezerinac, and B.K. Sandercock. 2016. Effects of geolocators on hatching success, return rates, breeding movements and change in body mass in 16 species of Arctic-breeding shorebirds. Movement Ecology 4: art12. URL: http://movementecologyjournal.biomedcentral.com/articles/10.1186/s40462-016-0077-6Background: Geolocators are useful for tracking movements of long-distance migrants, but potential negative effects on birds have not been well studied. We tested for effects of geolocators (0.8–2.0 g total, representing 0.1–3.9 % of mean body mass) on 16 species of migratory shorebirds, including five species with 2–4 subspecies each for a total of 23 study taxa. Study species spanned a range of body sizes (26–1091 g) and eight genera, and were tagged at 23 breeding and eight nonbreeding sites. We compared breeding performance and return rates of birds with geolocators to control groups while controlling for potential confounding variables. Result: We detected negative effects of tags for three small-bodied species. Geolocators reduced annual return rates for two of 23 taxa: by 63 % for semipalmated sandpipers and by 43 % for the arcticola subspecies of dunlin. High resighting effort for geolocator birds could have masked additional negative effects. Geolocators were more likely to negatively affect return rates if the total mass of geolocators and color markers was 2.5–5.8 % of body mass than if tags were 0.3–2.3 % of body mass. Carrying a geolocator reduced nest success by 42 % for semipalmated sandpipers and tripled the probability of partial clutch failure in semipalmated and western sandpipers. Geolocators mounted perpendicular to the leg on a flag had stronger negative effects on nest success than geolocators mounted parallel to the leg on a band. However, parallel-band geolocators were more likely to reduce return rates and cause injuries to the leg. No effects of geolocators were found on breeding movements or changes in body mass. Among-site variation in geolocator effect size was high, suggesting that local factors were important. Conclusions: Negative effects of geolocators occurred only for three of the smallest species in our dataset, but were substantial when present. Future studies could mitigate impacts of tags by reducing protruding parts and minimizing use of additional markers. Investigators could maximize recovery of tags by strategically deploying geolocators on males, previously marked individuals, and successful breeders, though targeting subsets of a population could bias the resulting migratory movement data in some species

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide dosing recommendations for fluvoxamine, paroxetine, citalopram, escitalopram, and sertraline based on CYP2D6 and/or CYP2C19 genotype (updates at www.pharmgkb.org)