17 research outputs found
Exploring the Tradeoffs between Programmability and Efficiency in Data-Parallel Accelerators
We present a taxonomy and modular implementation approach for data-parallel accelerators, including the MIMD, vector-SIMD, subword-SIMD, SIMT, and vector-thread (VT) architectural design patterns. We have developed a new VT microarchitecture, Maven, based on the traditional vector-SIMD microarchitecture that is considerably simpler to implement and easier to program than previous VT designs. Using an extensive design-space exploration of full VLSI implementations of many accelerator design points, we evaluate the varying tradeoffs between programmability and implementation efficiency among the MIMD, vector-SIMD, and VT patterns on a workload of microbenchmarks and compiled application kernels. We find the vector cores provide greater efficiency than the MIMD cores, even on fairly irregular kernels. Our results suggest that the Maven VT microarchitecture is superior to the traditional vector-SIMD architecture, providing both greater efficiency and easier programmability
Recommended from our members
Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. We find that three paralogs of human-specific NOTCH2NL are highly expressed in radial glia. Functional analysis reveals that different alleles of NOTCH2NL have varying potencies to enhance Notch signaling by interacting directly with NOTCH receptors. Consistent with a role in Notch signaling, NOTCH2NL ectopic expression delays differentiation of neuronal progenitors, while deletion accelerates differentiation into cortical neurons. Furthermore, NOTCH2NL genes provide the breakpoints in 1q21.1 distal deletion/duplication syndrome, where duplications are associated with macrocephaly and autism and deletions with microcephaly and schizophrenia. Thus, the emergence of human-specific NOTCH2NL genes may have contributed to the rapid evolution of the larger human neocortex, accompanied by loss of genomic stability at the 1q21.1 locus and resulting recurrent neurodevelopmental disorders
Review: imaging technologies for flow cytometry
High throughput single cell imaging is a critical enabling and driving technology in molecular and cellular biology, biotechnology, medicine and related areas. Imaging flow cytometry combines single-cell imaging capabilities of microscopy with the high-throughput capabilities of conventional flow cytometry. Recent advances in imaging flow cytometry are remarkably revolutionizing the single-cell analysis. This article describes recent imaging flow cytometry technologies and their challenges