543 research outputs found

    Maragro Group : equity valuation

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    The aim of this dissertation is to estimate the fair value of the equity of Maragro Group, an enterprise located in Romania and operating in the Farming segment. The valuation has been performed by taking into consideration the latest financial information available as well as predictions made by the management team regarding the 2017-2018 campaign. For these reasons, the value of the company shall be intended as of the 31.12.2017. Methods used for the valuation include the discounted Cash-flow methodology and more specifically the Adjusted Present Value approach, whereas multiples have been taken into consideration as to analyze the possible differences that characterize the Group as opposed to the companies representing the peer group. The outcome of this study is that Maragro Group shall be attributed a total enterprise value of 254.343.809 RON and an Equity value of 177.437.682 RON.O objetivo desta dissertação é estimar o valor das ações do Grupo Marago, uma empresa localizada na Romênia que opera no setor agrícola. A avaliação foi realizada levando em consideração os últimos balanços financeiros assim como previsões realizadas pela equipe de gestão considerando os levantamentos de 2017-2018. Por essas razões, o valor da companhia será o estipulado em 31.12.2017. Os métodos usados para a avaliação incluem a metodologia do discounted Cash-flow e mais especificamente o valor presente ajustado, enquanto múltiplos fatores foram levados em consideração para analisar a possíveis diferenças que caracterizam o grupo como diferenciado dos demais. O resultado deste estudo é que ao Grupo Magoro deverá ser atribuído o valor total de 254.343.809RON e com valor de ação de 177.437.682 RON

    Modelling tertiary creep in geomaterials using a continuum damage mechanics approach.

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    Tertiary creep is often observed in soft rocks and it represents a problem in a mining environment. Tertiary creep behaviour appears due to progressive micro cracking of the material and would result in a loss of strength and stiffness, which may eventually lead to failure and a complete loss of load carrying capability of the material. In this paper, the authors combined the continuum damage mechanics within the framework of hyperplasticity, thus encompassing viscoplasticity and damage within a single theory. The authors present a family of models which obeys the laws of thermodynamics. The entire constitutive behaviour is derived from two scalar potentials; a free energy potential which provides the elasticity law, and a dissipation potential which provides the yield function, the direction of plastic flow and the evolution of a damage variable. No additional assumptions are required. These new models require only few parameters which have physical meanings and are capable of capturing tertiary creep observed in soft rocks

    Tensile Strength of Artificially Cemented Sandstone Generated via Microbially Induced Carbonate Precipitation.

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    Funder: bp International Centre for Advanced Materials (bp-ICAM)Artificially bio-cemented sands treated with microbially induced calcite precipitation are weakly cemented rocks representing intermediate materials between locked and carbonate sands. Variations in cementation significantly affect the strength of sample, particularly tensile stregth. The modes of fracture and the surface characteristics resulting from the indirect tensile strength tests (Brazilian tests) are strongly correlated with the specimen strength and consequently the degree of cementation. This study examines the tensile strength of bio-cemented fine and coarse sands (average particle diameter 0.18 and 1.82 mm, respectively) and investigates failure modes by recording fracture evolution at both sides of specimen and surface characteristics of the reconstructed surfaces. The dimensionless slope parameter Z2 provided the best fit with respect to tensile strength while the power spectral density was a good indicator of surface anisotropy. Finally, wavelet decomposition allowed for comparison of fracture surface characteristics of the two sands ignoring the grain size effects

    Functional validation of miRNAs targeting genes of DNA double-strand break repair to radiosensitize non-small lung cancer cells

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    Abstract DNA-Double strand breaks (DSBs) generated by radiation therapy represent the most efficient lesions to kill tumor cells, however, the inherent DSB repair efficiency of tumor cells can cause cellular radioresistance and impact on therapeutic outcome. Genes of DSB repair represent a target for cancer therapy since their down-regulation can impair the repair process making the cells more sensitive to radiation. In this study, we analyzed the combination of ionizing radiation (IR) along with microRNA-mediated targeting of genes involved in DSB repair to sensitize human non-small cell lung cancer (NSCLC) cells. MicroRNAs are natural occurring modulators of gene expression and therefore represent an attractive strategy to affect the expression of DSB repair genes. As possible IR-sensitizing targets genes we selected genes of homologous recombination (HR) and non-homologous end joining (NHEJ) pathway (i.e. RAD51, BRCA2, PRKDC, XRCC5, LIG1). We examined these genes to determine whether they may be real targets of selected miRNAs by functional and biological validation. The in vivo effectiveness of miRNA treatments has been examined in cells over-expressing miRNAs and treated with IR. Taken together, our results show that hsa-miR-96-5p and hsa-miR-874-3p can directly regulate the expression of target genes. When these miRNAs are combined with IR can decrease the survival of NSCLC cells to a higher extent than that exerted by radiation alone, and similarly to radiation combined with specific chemical inhibitors of HR and NHEJ repair pathway
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