A Nicotinic Acetylcholine Receptor Agonist Prevents Loss of Retinal Ganglion Cells in a Glaucoma Model

Purpose.: The purpose of this study was to analyze the neuroprotective effect of an α7 nAChR agonist, PNU-282987, using an in vivo model of glaucoma in Long Evans rats. Methods.: One eye in each animal was surgically manipulated to induce glaucoma in control untreated animals and in animals that were treated with intravitreal injections of PNU-282987. To induce glaucoma-like conditions, 0.05 mL of 2 M NaCl was injected into the episcleral veins of right eyes in each rat to create scar tissue and increase intraocular pressure. The left eye in each rat acted as an internal control. One month following NaCl injection, rats were euthanized, retinas were removed, flatmounted, fixed, and nuclei were stained with cresyl violet or RGCs were immunostained with an antibody against Thy 1.1 or against Brn3a. Stained nuclei in the RGC layer and labeled RGCs in NaCl-injected retinas were counted and compared with cell counts from untreated retinas in the same animal. Results.: NaCl injections into the episcleral veins caused a significant loss of cells by an average of 27.35% (±2.12 SEM) in the RGC layer within 1 month after NaCl injection, which corresponded to a significant loss of RGCs. This loss of RGCs was eliminated if 5 μL of 100 μM PNU-282987 was injected into the right eye an hour before NaCl injection. Conclusions.: The results from this study support the hypothesis that the α7 agonist, PNU-282987, has a neuroprotective effect in the rat retina. PNU-282987 may be a viable candidate for future therapeutic treatments of glaucoma

Automated Implementation of Windows-related Security-Configuration Guides

Hardening is the process of configuring IT systems to ensure the security of the systems' components and data they process or store. The complexity of contemporary IT infrastructures, however, renders manual security hardening and maintenance a daunting task. In many organizations, security-configuration guides expressed in the SCAP (Security Content Automation Protocol) are used as a basis for hardening, but these guides by themselves provide no means for automatically implementing the required configurations. In this paper, we propose an approach to automatically extract the relevant information from publicly available security-configuration guides for Windows operating systems using natural language processing. In a second step, the extracted information is verified using the information of available settings stored in the Windows Administrative Template files, in which the majority of Windows configuration settings is defined. We show that our implementation of this approach can extract and implement 83% of the rules without any manual effort and 96% with minimal manual effort. Furthermore, we conduct a study with 12 state-of-the-art guides consisting of 2014 rules with automatic checks and show that our tooling can implement at least 97% of them correctly. We have thus significantly reduced the effort of securing systems based on existing security-configuration guides

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

Intrinsic velocity differences between larynx raising and larynx lowering.

In this study, 23 subjects produced cyclic transitions between rounded vowels and unrounded vowels as in /o-i-o-i-o-…/ at two specific speaking rates. Rounded vowels are typically produced with a lower larynx position than unrounded vowels. This contrast in vertical larynx position was further amplified by producing the unrounded vowels with a higher pitch than the rounded vowels. The vertical larynx movements of each subject were measured by means of object tracking in laryngeal ultrasound videos. The results indicate that larynx lowering was on average 26% faster than larynx raising, and that this velocity difference was more pronounced in woman than in men. Possible reasons for this are discussed with a focus on specific biomechanical properties. The results can help to interpret vertical larynx movements with regard to underlying neural control and aerodynamic conditions, and to improve movement models for articulatory speech synthesis

Favoritism by the governing elite

In this paper, we study the extent to which ministers engage in regional favoritism. We are the first to provide a comprehensive analysis of a larger set of the governing elite, not just focusing on the primary leader. We hand-collect birthplaces of this governing elite globally. Combining this information with extended night-time luminosity and novel population data over the period from 1992 to 2016, we utilize a staggered difference-in-differences estimator and find that birthplaces of ministers globally emit on average roughly 7% more nightlight. We do not find evidence that this is driven by, or induces migration to their home regions. The size of our data set lets us investigate heterogeneities along a number of dimensions: political power, ministerial portfolio, and the institutional setting

Regional redistribution of mineral resource wealth in Africa

We study the economic implications of mineral resource activity for non-mining regions at the grid-level across the African continent. We find that capital cities benefit from mineral resource activity anywhere in the country. Leaders’ birth regions also benefit, but only in autocratic regimes. Generic non-mining regions, on the other hand, are worse off. These results suggest that regional redistribution of resource rents in Africa is primarily undertaken to the benefit of capital cities and leaders’ birth regions. In contrast, non-mining regions do not appear to be sufficiently compensated for the negative spillovers they may face due to mining activity elsewhere in the country

Favoritism by the governing elite

In this paper, we study the extent to which ministers engage in regional favoritism. We are the first to provide a comprehensive analysis of a larger set of the governing elite, not just focusing on the primary leader. We hand-collect birthplaces of this governing elite globally. Combining this information with extended night-time luminosity and novel population data over the period from 1992 to 2016, we utilize a staggered difference-in-differences estimator and find that birthplaces of ministers globally emit on average roughly 7% more nightlight. We do not find evidence that this is driven by, or induces migration to their home regions. The size of our data set lets us investigate heterogeneities along a number of dimensions: political power, ministerial portfolio, and the institutional setting

Favoritism by the governing elite

In this paper, we study the extent to which ministers engage in regional favoritism. We are the first to provide a comprehensive analysis of a larger set of the governing elite, not just focusing on the primary leader. We manually collect birthplaces of this governing elite globally. Combining this information with extended nighttime luminosity and novel population data over the period from 1992 to 2016, we utilize a staggered difference-in-differences estimator and find that birthplaces of ministers globally emit on average roughly 9 % more nightlight. This result is predominantly attributable to the African sub-sample. We find no evidence that the measured effect is driven by, or induces, migration to the home regions of ministers. The size of our data set lets us investigate heterogeneities along a number of dimensions: political power, ministerial portfolio, and the institutional setting.In dieser Studie untersuchen wir, in welchem Ausmaß Minister regionale Begünstigung betreiben. Wir sind die Ersten, die eine umfassende Analyse eines größeren Datensatzes der regierenden Elite vornehmen, der sich nicht nur auf Staatsoberhäupter bzw. Regierungschefs konzentriert. Dazu sammeln wir Informationen über die Geburtsorte von Ministern weltweit durch qualitative Recherche. Diese Informationen kombinieren wir mit erweiterten Daten zur nächtlichen Beleuchtung und Bevölkerungsdaten für den Zeitraum von 1992 bis 2016. Wir verwenden einen gestaffelten Difference-in-Differences-Schätzer und stellen fest, dass die Geburtsorte von Ministern im Durchschnitt etwa 9% mehr Nachtlicht ausstrahlen. Dieser Effekt wird hauptsächlich von afrikanischen Ländern getrieben. Darüber hinaus finden wir keine Hinweise darauf, dass dieser Effekt durch Migration in die Heimatregionen von Ministern verursacht oder gefördert wird. Die Größe unseres Datensatzes ermöglicht es uns, Heterogenitäten entlang einer Reihe von Dimensionen zu untersuchen: politische Macht, Portfolios und institutionelle Rahmenbedingungen